Results 201 to 210 of about 53,480 (280)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

MassBank: an open and FAIR mass spectral data resource. [PDF]

Nucleic Acids Res
Neumann S, Meier R, Wenk M, Elapavalore A, Nishioka T, Schulze T, Stravs M, Tsugawa H, Matsuda F, Schymanski EL.   +9 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Protocol for obtaining cancer type and subtype predictions using subSCOPE. [PDF]

STAR Protoc
Grewal JK, Robertson AG, Ellrott K, Wong CK, Lee JA, Yau C, Tercan B, Castro MAA, Benz CC, Cancer Genome Atlas Analysis Network, Zenklusen JC, Cherniack AD, Laird PW, Jones SJM.   +13 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Reproducible Boolean model analyses and simulations with the CoLoMoTo software suite: a tutorial. [PDF]

Interface Focus
Noël V, Naldi A, Calzone L, Paulevé L, Thieffry D.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

ProkBERT PhaStyle: accurate phage lifestyle prediction with pretrained genomic language models. [PDF]

Bioinform Adv
Juhász J, Ligeti-Nagy N, Bodnár B, Juhász J, Pongor S, Ligeti B.   +5 more
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Lamprey <i>FOXN1</i> rescues the block of thymic epithelial cell development in the mouse <i>Foxn1</i>-deficient thymic rudiment. [PDF]

Proc Natl Acad Sci U S A
Morimoto R, Zhang G, Thomas OS, Docker MF, Yick JL, Devloo-Delva F, Swann J, Diekhoff D, Boehm T.   +8 more
europepmc   +1 more source