Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
OmniCellX: A Versatile and Comprehensive Browser-Based Tool for Single-Cell RNA Sequencing Analysis. [PDF]
Long R, Suoangbaji T, Ho DW.
europepmc +1 more source
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin +6 more
wiley +1 more source
Shinyscreen: mass spectrometry data inspection and quality checking utility. [PDF]
Kondić T +6 more
europepmc +1 more source
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic +6 more
wiley +1 more source
The influence of climate change on growth of Arctic charr (<i>Salvelinus alpinus</i>). [PDF]
Gendron HK, Tallman RF, Docker MF.
europepmc +1 more source
Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams +14 more
wiley +1 more source
Magellon - an extensible platform for cryo-EM data visualization, management and processing. [PDF]
Khoshbin B +9 more
europepmc +1 more source
Publisher Correction: Amphoteric chalcogen-bonding and halogen-bonding rotaxanes for anion or cation recognition. [PDF]
Tse YC +4 more
europepmc +1 more source
Encouraging reusability of computational research through Data-to-Knowledge Packages - A hydrological use case. [PDF]
Konkol M +4 more
europepmc +1 more source

