Results 241 to 250 of about 293,887 (293)

Econazole Exhibits In Vitro and In Vivo Efficacy Against Leishmania amazonensis. [PDF]

Pharmaceuticals (Basel)
Mesquita JT, Dias IO, Tempone AG, Reimão JQ.   +3 more
europepmc   +1 more source

Planting Lime at the Station: Building a Theoretical Docking Station Network to Analyze the Spatiotemporal Characteristics of Dockless Bikeshare in Seattle

William Feeney
openalex   +1 more source

Data Sheet 1_Integrating network pharmacology, IPA, and molecular docking to reveal the anti-osteoporosis effects of EA and EB via the FAK pathway.zip

Ziheng Wei (4284208), Fei You (2293990), Henghui Li (547700), Si Wu (154794), Fen Tang (6113984), Xiangyang Wan (21644837), Huizhong Dong (21644840), Wenxuan Huang (4434001), Songyan Gao (4284205), Bo Cai (62436), Xiongsheng Chen (1774558), Xin Dong (196020)   +11 more
openalex   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Computational repurposing of approved drugs targeting KRAS G12D and EGFR for colorectal cancer therapy. [PDF]

PLoS One
Ibraheem W, Alsheikh F, Alzain AA, Bhongade BA, Ejaz L, Baig H, Robinson RC, El-Tanani M.   +7 more
europepmc   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Comparison of In Vitro Multiple Physiological Activities of Cys-Tyr-Gly-Ser-Arg (CYGSR) Linear and Cyclic Peptides and Analysis Based on Molecular Docking. [PDF]

Biomolecules
Kim GH, Bang JE, Kim BM.
europepmc   +1 more source

In silico assessment of 4 methoxypelargonidin and luteolinidin from Parthenium hysterophorous as acetylcholinesterase inhibitors of Phlebotomus Papatasi. [PDF]

Sci Rep
Choudhary H, Parshant, Saket A, Singh S, Kumar Ch RS, Srinivasan T, Shukla R.   +6 more
europepmc   +1 more source

Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure. [PDF]

Front Cardiovasc Med
Ren J, Li Z, Wang Y, Wang Y, Li J.
europepmc   +1 more source