Results 81 to 90 of about 293,887 (293)

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

On‐Surface Synthesis of Bismuth Monolayers through Ice‐Confined Redox Reactions

Advanced Materials, EarlyView.
We report an ice‐confined growth strategy for the synthesis of atomically thin 2D bismuth and related 2D metals. This approach involves rapid freezing of a BiCl3 aqueous solution on an aluminum foil using liquid nitrogen, which triggers interfacial redox reactions between the ice and the aluminum surface.
Zexiang He, Depeng Wang, Wentao Fan, Songlin Liu, Antonio Gaetano Ricciardulli, Haixia Zhong, Yiyong Mai, Paolo Samorì, Sheng Yang   +8 more
wiley   +1 more source

Microwave-assisted organic synthesis, antimycobacterial activity, structure–activity relationship and molecular docking studies of some novel indole-oxadiazole hybrids

, 2022
Nisheeth C. Desai, Hardik Somani, Harsh K. Mehta, Dharmpalsinh J. Jadeja, Ashvinkumar G. Khasiya, Vijay M. Khedkar   +5 more
openalex   +1 more source

Low‐Strain Flexible Ink‐Based Sensors Enable Hyperelastic Inflation Perception Via Geometric Patterning for Balloon‐Type Robots

Advanced Robotics Research, EarlyView.
Integrating proprioceptive capabilities in balloon‐type robots enhances safe human–machine interactions. Traditional pressure estimates are inadequate due to nonlinear relationships. Instead, embedding stretchable sensors effectively measures deformation. This design optimizes sensor geometry to minimize damage risks.
Wenchao Yue, Shuoyuan Chen, Yan Ke, Yingyi Wen, Ruijie Tang, Guohua Hu, Hongliang Ren   +6 more
wiley   +1 more source

Munc18-1: Sequential Interactions with the Fusion Machinery Stimulate Vesicle Docking and Priming [PDF]

, 2007
Attila Gulyás-Kovács, Heidi de Wit, Ira Milošević, Olexiy Kochubey, Ruud F. Toonen, Jürgen Klingauf, Matthijs Verhage, Jakob B. Sørensen   +7 more
openalex   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Orchestration of Genetic Alterations in PSEN1 and PSEN2 Genes in Development of Alzheimer's Disease through Computational Analysis

Global Medical Genetics
Dementia is a syndrome that can cause a number of progressive illnesses that affect memory, thinking, and ability to perform everyday tasks. Alzheimer's disease (AD) is the most common cause of dementia and represents a major public health problem. AD is
Asif Mir, Zainab Kamran, Wajid Iqbal
doaj   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme

Molecules, 2012
Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs.
Eugene Demchuk, Bruce A. Fowler, James C. Fuscoe, Richard D. Beger, Weida Tong, Jon G. Wilkes, Dan A. Buzatu, Weigong Ge, Laura K. Schnackenberg, Yunfeng Tie, Brooks McPhail, Huixiao Hong, Bruce A. Pearce   +12 more
doaj   +1 more source