Results 111 to 120 of about 135,313 (306)

Classification of Pigs with Tail Lesions from Different Farrowing and Rearing Systems during Rearing and Fattening Period

Animals, 2019
The aim of the present study was to classify and characterise pigs with tail lesions using a combined parameter based on the frequency and duration of tail lesions and to find out whether biologically relevant groups could be separated by cluster ...
Maria Gentz, Anita Lange, Sebastian Zeidler, Imke Traulsen   +3 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery
ABSTRACTIrritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. Cinnamaldehyde (CA) possesses anti‐inflammatory, antibacterial, and digestive‐regulatory properties. However, its therapeutic potential for IBS and mechanisms are not understood.
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
openaire   +1 more source

Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model

PLOS ONE
Currently, no safe vaccine against leishmaniasis is available. So far, different control strategies against numerous reservoir hosts and biological vectors have not been environment-friendly and feasible. Hence, employing medicinal components and conventional drugs could be a promising approach to developing novel therapeutic alternatives.
Farzaneh Zarrinkar, Iraj Sharifi, Ehsan Salarkia, Alireza Keyhani, Zahra Babaei, Ali Khamesipour, Maryam Hakimi Parizi, Elaheh Molaakbari, Fatemeh Sharifi, Shahriar Dabiri, Mehdi Bamorovat   +10 more
openaire   +3 more sources

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]

, 2019
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra, Kõivomägi, Mardo, Rubin, Seth M, Sage, Julien, Skotheim, Jan M, Tambo, Carrie S, Topacio, Benjamin R, Xie, Shicong, Zatulovskiy, Evgeny   +8 more
core  

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Anti-vitiligo Mechanisms of Traditional Chinese Medicine Compound Baqia Danshen Liniment: Network Pharmacology, Molecular Docking, and Animal Model Insights

Pharmacognosy Magazine
Background Vitiligo is a skin condition characterized by depigmentation and has proven difficult to treat. Traditional Chinese Medicine (TCM) offers potential therapeutic alternatives. Compound Baqian Danshen Liniment (CBDL) is a multicomponent herbal formula used in TCM.
Jiaxin Wang, Juan Liu, Yahui Wang, Kailibinuer Abulaiti, Weili Sun, Maihesumu Aikemu, Muhebuli Abulizi   +6 more
openaire   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Analysing the antidepressant and drug efflux competence of Clitoria ternatea L. as P-glycoprotein inhibitor to facilitate blood brain barrier

Acta Scientiarum: Biological Sciences, 2019
Clitoria ternatea L. is a vital ayurvedic herb featured with a wide spectrum of mental health benefits. The present study investigates the competence of the plant against depression and to inhibit the membrane efflux protein P-glycoprotein (P-gp) that ...
Arockiya Anita Margret, Violet Dhayabaran, Suvaiarasan Suvaithenamudhan, Subbiah Parthasarathy   +3 more
doaj   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source