Results 111 to 120 of about 133,738 (306)

Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening

Biomedicine & Pharmacotherapy, 2017
Due to its unclear pathophysiology, the pharmacological treatment of fibromyalgia is a challenge for researchers. Studies using medicinal plants, such as those from the genus Lippia, complexed with cyclodextrins (CDs) have shown innovative results.The present research intended to evaluate the effect of an inclusion complex containing β-cyclodextrin ...
Pollyana S, Siqueira-Lima, Renan G, Brito, Heitor G, Araújo-Filho, Priscila L, Santos, Angélica, Lucchesi, Adriano A S, Araújo, Paula P, Menezes, Luciana, Scotti, Marcus T, Scotti, Irwin R A, Menezes, Henrique D M, Coutinho, Gokhan, Zengin, Abdurrahman, Aktumsek, Angelo R, Antoniolli, Lucindo J, Quintans-Júnior, Jullyana S S, Quintans   +15 more
openaire   +2 more sources

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Classification of Pigs with Tail Lesions from Different Farrowing and Rearing Systems during Rearing and Fattening Period

Animals, 2019
The aim of the present study was to classify and characterise pigs with tail lesions using a combined parameter based on the frequency and duration of tail lesions and to find out whether biologically relevant groups could be separated by cluster ...
Maria Gentz, Anita Lange, Sebastian Zeidler, Imke Traulsen   +3 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery
ABSTRACTIrritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. Cinnamaldehyde (CA) possesses anti‐inflammatory, antibacterial, and digestive‐regulatory properties. However, its therapeutic potential for IBS and mechanisms are not understood.
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
openaire   +1 more source

Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model

PLOS ONE
Currently, no safe vaccine against leishmaniasis is available. So far, different control strategies against numerous reservoir hosts and biological vectors have not been environment-friendly and feasible. Hence, employing medicinal components and conventional drugs could be a promising approach to developing novel therapeutic alternatives.
Farzaneh Zarrinkar, Iraj Sharifi, Ehsan Salarkia, Alireza Keyhani, Zahra Babaei, Ali Khamesipour, Maryam Hakimi Parizi, Elaheh Molaakbari, Fatemeh Sharifi, Shahriar Dabiri, Mehdi Bamorovat   +10 more
openaire   +3 more sources

Spider Silk–Integrated Biomimetic Micropillars With Dual Adhesion for Improved Wound Hemostasis and Healing

Advanced Materials Technologies, EarlyView.
The patch mimics the dual physicochemical adhesion mechanisms of gecko toe micropillars and spider silk proteins, enabling strong interfacial bonding via partially cured micropillars. Its facile fabrication allows customization for precision medicine, while its motion responsiveness offers potential for real‐time wound monitoring.
Chengxin Luan, Meng Wei, Xinran Chen, Ni Gan, Bingbing Gao   +4 more
wiley   +1 more source

Sini San ameliorates lipid metabolism in hyperprolactinemia rat with liver-depression

Current Research in Food Science
Sini San (SNS) is used to treat liver depression and is applied in both food and herbal medicine. Hyperprolactinemia (HPRL) is a common endocrine disorder, and patients with HPRL are usually associated with depressive symptoms.
Weidong Xu, Shasha Tian, Guanqun Mao, Yu Li, Hua Qian, Wenhua Tao   +5 more
doaj   +1 more source

Analysing the antidepressant and drug efflux competence of Clitoria ternatea L. as P-glycoprotein inhibitor to facilitate blood brain barrier

Acta Scientiarum: Biological Sciences, 2019
Clitoria ternatea L. is a vital ayurvedic herb featured with a wide spectrum of mental health benefits. The present study investigates the competence of the plant against depression and to inhibit the membrane efflux protein P-glycoprotein (P-gp) that ...
Arockiya Anita Margret, Violet Dhayabaran, Suvaiarasan Suvaithenamudhan, Subbiah Parthasarathy   +3 more
doaj   +1 more source

Anti-vitiligo Mechanisms of Traditional Chinese Medicine Compound Baqia Danshen Liniment: Network Pharmacology, Molecular Docking, and Animal Model Insights

Pharmacognosy Magazine
Background Vitiligo is a skin condition characterized by depigmentation and has proven difficult to treat. Traditional Chinese Medicine (TCM) offers potential therapeutic alternatives. Compound Baqian Danshen Liniment (CBDL) is a multicomponent herbal formula used in TCM.
Jiaxin Wang, Juan Liu, Yahui Wang, Kailibinuer Abulaiti, Weili Sun, Maihesumu Aikemu, Muhebuli Abulizi   +6 more
openaire   +1 more source