Results 131 to 140 of about 2,926,121 (366)

Beam model development and clinical experience with RadCalc for treatment plan quality assurance in online adaptive workflow with an MR‐linac

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The aim of this work was to report on the optimization, commissioning, and validation of a beam model using a commercial independent dose verification software RadCalc version 7.2 (Lifeline Software Inc, Tyler, TX, USA), along with 4 years of experience employing RadCalc for offline and online monitor unit (MU) verification on the ...
Urszula Jelen, Zoë Moutrie, Jack D Aylward, Michael G Jameson   +3 more
wiley   +1 more source

In silico study on anticonvulsant activity of isoxazole and thiazole derivatives active in subcutaneous pentylenetetrazole animal model

Journal of King Saud University: Science, 2020
Quantitative structure-activity relationship (QSAR) and molecular docking studies have been done on 28 isoxazole and thiazole derivatives with anticonvulsant activity in subcutaneous pentylenetetrazole animal model.
Adedirin Oluwaseye, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj  

Development of a Piglet Grimace Scale to Evaluate Piglet Pain Using Facial Expressions Following Castration and Tail Docking: A Pilot Study

Frontiers in Veterinary Science, 2017
Facial expressions are increasingly being used to assess pain in non-human species, including rodents, horses, and lambs. The development of these species-specific grimace scales has allowed for more rapid pain detection, which can lead to better animal ...
A. Viscardi, M. Hunniford, P. Lawlis, M. Leach, P. Turner   +4 more
semanticscholar   +1 more source

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev, A Sali, A Villarroel, AI Sobolevskii, AI Sobolevsky, AI Sobolevsky, AI Sobolevsky, BO Dubrovsky, C Beck, CE Weaver, CE Weaver Jr., CH Lee, CL Kussius, CT Smothers, CT Smothers, E Karakas, E Stastna, EE Baulieu, G Abdrachmanova, GQ Chen, H Havlikova, HR Chang, I Cerny, J Borovska, J Dai, J Zuo, JA Kemp, K Kashiwagi, K Vales, L Nowak, L Rambousek, L Vyklicky Jr., LM Arnostova, LP Wollmuth, M Benveniste, M Hollmann, M Horak, M Korinek, M Park-Chung, M Park-Chung, M Park-Chung, M Petrovic, M Sheng, M Xu, MA Larkin, MA Lomize, MA Lynch, MF Sanner, ML Mayer, MM Zarei, N Kashiwabuchi, NJ Sucher, PA Lapchak, R Kancheva, R Kazi, R Sprengel, RH Evans, S Schreier, SE Murthy, SF Traynelis, SH Mellon, SI Mota   +61 more
core   +1 more source

Traditional Chinese medicine for the treatment of chronic inflammatory diseases: A review of inhibitors for NLRP3 inflammasome

Advanced Chinese Medicine, Volume 2, Issue 1, Page 1-12, March 2025.
Abstract The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome is a vital part of the innate immune response, whilst its aberrant activation drives the progression of several noncommunicable diseases. It induces caspase‐1 activation and the downstream substrates involved with the processing and secretion of the pro‐inflammatory cytokines IL‐1β ...
Yucen Zou, Pei Ma, Bin Li, Jiushi Liu, Lifeng Yue, Bengang Zhang, Haitao Liu   +6 more
wiley   +1 more source

Efforts to Ban the Routine Tail Docking of Pigs and to Give Pigs Enrichment Materials via EU Law: Where Do We Stand a Quarter of a Century on?

Animals, 2019
Simple Summary Enforcing legislation on the welfare of pigs is currently one of the European Commission’s priorities in the area of animal welfare. This article focuses on the legal ban on the routine docking of tails and the provision of enrichment to ...
E. Nalon, N. De Briyne
semanticscholar   +1 more source

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]

, 2019
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben, Chahal, Kirti Kandhwal, Chen, Clark C, Durden, Donald L, Kufareva, Irina, Li, Jie, Parle, Milind, Wechsler-Reya, Robert J   +7 more
core  

Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts [PDF]

, 2018
Oregonin is an open-chain diarylheptanoid isolated from Alnus incana bark that possesses remarkable antioxidant and anti-inflammatory properties, inhibits adipogenesis, and can be used in the prevention of obesity and related metabolic disorders.
Abadjieva, Desislava, Botta, Bruno, Chervenkov, Mihail, De Paolis, Elisa, Kistanova, Elena, Krasilnikova, Jelena, Lauberte, Liga, Mladenova, Vanya, Mori, Mattia, Stoyanova, Elena, Telysheva, Galina   +10 more
core   +3 more sources

Modeling and Accessing Smart Materials with Integrity Constraints in the Shapes Constraint Language and Ontologies—The SmaDi Way

Advanced Engineering Materials, Volume 27, Issue 8, April 2025.
Integrity constraints enforce consistency and completeness on data. The article discusses a newly developed validator for checking integrity constraints in Shapes Constraint Language (SHACL) through reduction to SPARQL Protocol and RDF Query Language (SPARQL) queries. It can be used with systems for ontology‐based database access.
Özgür L. Özçep, Mena Leemhuis, Maximilian Winkler, Robert Courant, Thomas Sattel, Jürgen Maas   +5 more
wiley   +1 more source

Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State [PDF]

, 2016
The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation between this system and the mitochondrial enzyme cyclophilin D.
Bindoli, Alberto, Cali', Tito, Citta, Anna, Folda, Alessandra, Rigobello, MARIA PIA, Scalcon, Valeria, Scutari, Guido, Zonta, Francesco   +7 more
core   +1 more source