Results 11 to 20 of about 84,234 (259)

Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema

Drug Design, Development and Therapy, 2023
Yuan Cui,1,2 Jingyi Hu,2 Yanan Li,1,2 Ryan Au,1,2 Yulai Fang,2 Cheng Cheng,1 Feng Xu,1,2 Weiyang Li,1,2 Yuguang Wu,1,2 Lei Zhu,2 Hong Shen2 1Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Affiliated Hospital of Nanjing ...
Cui Y, Hu J, Li Y, Au R, Fang Y, Cheng C, Xu F, Li W, Wu Y, Zhu L, Shen H   +10 more
doaj   +3 more sources

Immunoenhancement effects of Ganoderma sinense peptides: Animal experiments, molecular mechanism and molecular docking

Journal of Functional Foods
The objective of the study was to investigate the immunomodulatory activity of low-molecular-weight peptides from Ganoderma sinense protein hydrolysates (named GSP) both in vitro and in vivo, as well as to identify candidate peptides from GSP and ...
Qian Yang, Huihong Zhang, Xiaolin Huang, Zhiqing Lin, Xixi Cai, Shaoyun Wang, Pengfen Gao, Yanda Zhang, Nanwen Zhang, Xiaole Chen   +9 more
doaj   +2 more sources

Molecular docking, simulations of animal peptides against the envelope protein of Dengue virus

Journal of Biomolecular Structure and Dynamics, 2023
Peptides are biologically active, small molecules with high specificity in its mode of action that can be effective at nanomolar concentrations. Peptide-based antiviral medicines have already been licensed and used to treat human immunodeficiency virus (HIV), influenza virus and hepatitis C virus. So far, no peptide drug has been approved for antiviral
Reena, Guntamadugu, Ranjani, Ramakrishnan, Gowtham, Darala, Sangeetha, Kothandan   +3 more
openaire   +2 more sources

SARS-CoV-2 prevalence in domestic and wildlife animals: A genomic and docking based structural comprehensive review

Heliyon, 2023
The SARS-CoV-2 virus has been identified as the infectious agent that led to the COVID-19 pandemic, which the world has seen very recently. Researchers have linked the SARS-CoV-2 outbreak to bats for the zoonotic spread of the virus to humans. Coronaviruses have a crown-like shape and positive-sense RNA nucleic acid.
Tuhin Das, Suranjana Sikdar, Md. Helal Uddin Chowdhury, Khandakar Jannatul Nyma, Md. Adnan   +4 more
openaire   +3 more sources

Molecular docking and anti-ulcerative potential of Cucumis (L. Inodorous) on ibuprofen induced gastric ulceration in male wistar animals

Biomedicine & Pharmacotherapy, 2023
The use of NSAIDs have caused stomach injury by inhibiting endogenous mucosal prostaglandin production. Cucumis melo is reported to possess antiulcer potential. This study investigates the mechanism underlying the antiulcer potentials of Cucumis melo (CUM).Thirty-five male Wistar rat were randomly assigned to each of seven groups; A(control given water
Grace, Adebayo-Gege, Zainab Shehu, Uthman, Moses Dele, Adams, Tarfa, Florence, Danazumi Umar, Haruna, Ngabea Murtala, Audu, Hamidu Jabba, Lawan, Ozegbe, Queen, Onwuchekwa, Chinedu, Ajibola, Meraiyebu, Ojo, Kafaru   +10 more
openaire   +2 more sources

Analysis of Housing Risk Factors for the Welfare of Lean and Heavy Pigs in a Sample of European Fattening Farms

Animals, 2021
Pig welfare is affected by housing conditions, the minimum requirements of which are set up by EU legislation. Animal and non-animal-based measures are useful indicators to investigate housing risk factors for pig welfare.
Paolo Ferrari, Alessandro Ulrici, Matteo Barbari   +2 more
doaj   +1 more source

In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

Marine Drugs, 2022
Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in ...
Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin   +3 more
doaj   +1 more source

Sedative-hypnotic-like effect and molecular docking of di-naphthodiospyrol from Diospyros lotus in an animal model

Biomedicine & Pharmacotherapy, 2017
Diospyros lotus Linn commonly known as date-plum, or Caucasian persimmon has multiple uses in folk medicine. Various parts of this plant is used for alleviating lumbago, dysponea, hemorrhage, insomnia, and hiccup. The plant extracts possess a variety of biological activities, such as anti-inflammatory, sedative, febrifuge, anti-microbial, vermifuge ...
Abdur, Rauf, Taibi Ben, Hadda, Ghias, Uddin, José P, Cerón-Carrasco, Jorge, Peña-García, Horacio, Pérez-Sánchez, Haroon, Khan, Saud, Bawazeer, Seema, Patel, Mohammad S, Mubarak, Tareq, Abu-Izneid, Yahia Nasser, Mabkhot   +11 more
openaire   +2 more sources

Lamb behaviour during and shortly after tail-docking

South African Journal of Animal Science
Routine husbandry procedures for lambs are increasingly scrutinised for their animal welfare implications. One such procedure is tail-docking, which is commonly performed to prevent breech blowfly strike.
M Teubes, AJ Scholtz, K Dzama, SWP Cloete   +3 more
doaj   +1 more source

Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies

Medicines, 2017
Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis.
Abul Hasanat, Tanvir Ahmad Chowdhury, Mohammad Shah Hafez Kabir, Mohammed Sohel Chowdhury, Md. Nazim Uddin Chy, Jackie Barua, Nishan Chakrabarty, Arkajyoti Paul   +7 more
doaj   +1 more source