Results 21 to 30 of about 84,234 (259)

Does tail docking prevent Cochliomyia hominivorax myiasis in sheep? A six-year retrospective cohort study

Animal Welfare
Tail docking is a husbandry practice widely incorporated in sheep farms around the world. It is an irreversible mutilation that impairs animal welfare, both immediately and in the longer term.
Giuliano Pereira de Barros, Maria José Hötzel, Marceli Carvalho da Silva, Laura Lívia Arias Avilés, Patrizia Ana Bricarello   +4 more
doaj   +1 more source

Exploring the mechanism of anti-fatigue of resveratrol based on network pharmacology and molecular docking, and in vitro studies

Scientific Reports, 2023
To investigate the potential mechanism of resveratrol in anti-fatigue by network pharmacology and molecular docking, and to investigate the anti-fatigue efficacy of resveratrol through in vitro animal experiments.
Peipei Ma, Jinlei Li, Qing Huang, Shijie Wei, Hurong Ge, Zhizhong Wang   +5 more
doaj   +1 more source

Improved effect of fresh ginseng paste (radix ginseng-ziziphus jujube) on hyperuricemia based on network pharmacology and molecular docking

Frontiers in Pharmacology, 2022
Background: Hyperuricemia (HUA) is a metabolic disease caused by reduced excretion or increased production of uric acid. This research aims to study the practical components, active targets, and potential mechanism of the “Radix ginseng (RG)-Ziziphus ...
Hao Zhang, Hao Zhang, Wei Liu, Wei Liu, Si-Min Qi, Si-Min Qi, Jian-Feng Chi, Qiang Gao, Xiang-Hui Lin, Shen Ren, Zi Wang, Xiu-juan Lei, Wei Li, Wei Li   +13 more
doaj   +1 more source

Circulating microRNA profiles are associated with acute pain and stress in castrated and tail docked lambs

Veterinary and Animal Science
Maintaining animal welfare is an essential component of animal production systems. However, multiple measurements are required to inform an animal's welfare state as there are currently no universal measurement tools.
Ryan J. Farr, Christopher Cowled, Carlos Rodrigues, Christina L. Rootes, Dana L.M. Campbell, Caroline Lee, Cameron R. Stewart, Danila Marini   +7 more
doaj   +1 more source

Review: The tale of the Finnish pig tail – how to manage non-docked pigs?

Animal, 2022
Tail biting is a serious behavioural problem in modern pig production, causing impaired animal welfare and economic losses. In most countries, the detrimental effects of tail biting are counteracted by docking pigs tails.
A. Valros
doaj   +1 more source

Why are most EU pigs tail docked? Economic and ethical analysis of four pig housing and management scenarios in the light of EU legislation and animal welfare outcomes

Animal, 2016
To limit tail biting incidence, most pig producers in Europe tail dock their piglets. This is despite EU Council Directive 2008/120/EC banning routine tail docking and allowing it only as a last resort.
R.B. D’Eath, J.K. Niemi, B. Vosough Ahmadi, K.M.D. Rutherford, S.H. Ison, S.P. Turner, H.T. Anker, T. Jensen, M.E. Busch, K.K. Jensen, A.B. Lawrence, P. Sandøe   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice

Annals of Medicine
Background Yigu decoction (YGD) is a traditional Chinese medicine prescription for the treatment of osteoporosis, although many clinical studies have confirmed its anti-OP effect, but the specific mechanism is still not completely clear.Methods In this ...
Kun Yan, Rui-Kun Zhang, Jia-Xin Wang, Hai-Feng Chen, Yang Zhang, Feng Cheng, Yi Jiang, Min Wang, Ziqi Wu, Xiao-Gang Chen, Zhi-Neng Chen, Gui-Jin Li, Xin-Miao Yao   +12 more
doaj   +1 more source