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Perfluorooctane sulfonate (PFOS) interferes with Cyp1a activity and dysregulates the aryl hydrocarbon receptor pathway in larval zebrafish (Danio rerio). [PDF]
Miller DH +5 more
europepmc +1 more source
Improving survival, growth rate, and animal welfare in piglets by avoiding teeth shortening and tail docking [PDF]
Piglets are subjected to several painful procedures during their first week of life, including ear tagging, teeth clipping or grinding (although routinely prohibited in Europe), tail docking (although routinely prohibited in Europe), needle injections (vaccination and iron injection), and castration might be performed for male piglets.
Bert Driessen, Geert Verbeke, Rony Geers
exaly +3 more sources
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The long and short of it: A review of tail docking in farm animals
Applied Animal Behaviour Science, 2011Tail docking involves amputating a portion of the tail for a variety of reasons. We review the scientific evidence for the rationale for tail docking, a description of the different methods used, the pain response to the procedure and the effectiveness of pain alleviation, and, finally, the alternatives to tail docking and policy regarding the practice.
Mhairi A. Sutherland, Cassandra B Tucker
exaly +2 more sources
Abstract Hesperetin (HE), a natural flavonoid exhibiting anti-inflammatory and antioxidant properties, holds significant potential in treating chronic obstructive pulmonary disease (COPD). Nonetheless, the precise mechanisms underlying its effects are yet to be fully elucidated.
Hongyang Wang
exaly +4 more sources
Archiv der Pharmazie, 2017
A series of new pyrimidine–triazine hybrids (4a–t) was designed and synthesized, from which potent anticonvulsant agents were identified. Most of the compounds exhibited promising anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment with higher safety ...
Meeta Sahu +6 more
openaire +2 more sources
A series of new pyrimidine–triazine hybrids (4a–t) was designed and synthesized, from which potent anticonvulsant agents were identified. Most of the compounds exhibited promising anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment with higher safety ...
Meeta Sahu +6 more
openaire +2 more sources
Computers in Biology and Medicine, 2023
Palmitic acid is a common ingredient in many foods and traditional Chinese medicines. However, modern pharmacological experiments have shown that palmitic acid has toxic side effects. It can damage glomeruli, cardiomyocytes, and hepatocytes, as well as promote the growth of lung cancer cells. Despite this, there are few reports evaluating the safety of
Lijuan Lv, Xiangpei Wang, Hongmei Wu
openaire +3 more sources
Palmitic acid is a common ingredient in many foods and traditional Chinese medicines. However, modern pharmacological experiments have shown that palmitic acid has toxic side effects. It can damage glomeruli, cardiomyocytes, and hepatocytes, as well as promote the growth of lung cancer cells. Despite this, there are few reports evaluating the safety of
Lijuan Lv, Xiangpei Wang, Hongmei Wu
openaire +3 more sources
Combinatorial Chemistry & High Throughput Screening, 2022
Background: The Yixiang capsule with traditional Chinese herbs Cistanches Herba, Hedysarum multijugum Maxim,Fructus Ligustri Lucidi,and Fructus lycii are the main raw materials in a modern herbal medicine preparation containing corresponding bioactive ingredients after extraction and processing.
Jing, Wang +5 more
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Background: The Yixiang capsule with traditional Chinese herbs Cistanches Herba, Hedysarum multijugum Maxim,Fructus Ligustri Lucidi,and Fructus lycii are the main raw materials in a modern herbal medicine preparation containing corresponding bioactive ingredients after extraction and processing.
Jing, Wang +5 more
openaire +2 more sources
Current Gene Therapy, 2020
Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed to elucidate the beneficial role of voglibose via in-silico in vitro to in-vivo studies in improving the postprandial glycaemic state by protection against strokeprone type 2 diabetes.
Pooja, Shah +4 more
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Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed to elucidate the beneficial role of voglibose via in-silico in vitro to in-vivo studies in improving the postprandial glycaemic state by protection against strokeprone type 2 diabetes.
Pooja, Shah +4 more
openaire +2 more sources
Tail docking and animal welfare
The Bovine Practitioner, 2004Tail docking is a common practice on many dairy farms, and is perceived by many farmers to improve cleanliness and enhance milking parlour efficiency. It is a controversial practice attracting increasing scrutiny by the animal welfare community. Scientific studies have been performed to evaluate physiological and behavioural responses to tail docking ...
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