Results 251 to 260 of about 2,926,121 (366)

NAD+ Metabolism Reprogramming Drives SIRT1‐Dependent Deacetylation Inducing PD‐L1 Nuclear Localization in Cervical Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The identification of PD‐L1 localization may be a key factor in the resistance to immunotherapy observed in patients. The discovery that PD‐L1 over expression is regulated by both transcriptional and post‐transcriptional processes. The acetyl‐proteomic analysis that identified SIRT1 as a key player in the deacetylation of histone H3 at lysines 27 and ...
Xinyi Lu, Pingping Jin, Qianyun Tang, Min Zhou, Hanjie Xu, Chen Su, Lei Wang, Feng Xu, Min Zhao, Yongxiang Yin, Jinqiu Zhang, Zhen Jia, Xinrui Peng, Jie Zhou, Lu Wang, Yan Chen, Min Wang, Min Yang, Daozhen Chen, Yu Chen   +19 more
wiley   +1 more source

Epimedium brevicornum Maxim alleviates diabetes osteoporosis by regulating AGE-RAGE signaling pathway. [PDF]

Mol Med
Lei SS, Wang YY, Huang XW, Wang XP, Gao M, Li B.   +5 more
europepmc   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Network Pharmacology and Experimental Validation Reveal Sishen Pill's Efficacy in Treating NSAID-Induced Small Intestinal Ulcers. [PDF]

Drug Des Devel Ther
Zhou J, Zhu F, Liang H, Sun L.
europepmc   +1 more source

Quorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Pseudomonas fluorescens 2P24 utilizes a LasI/LasR‐type quorum sensing (QS) system, MupI/MupR, to regulate carbon and nitrogen metabolism for optimal production of secondary metabolites as public goods, including 2,4‐diacetylphloroglucinol, mupirocin, and siderophores.
Jie Li, Mengxue Nie, Hongguang Ma, Xuanying Tao, Yanxia Sun, Xinyue Tu, Pingping Zhang, Li‐Qun Zhang, Rong Jia, Yong‐Xing He, Nannan Zhang, Honghua Ge   +11 more
wiley   +1 more source

Integrating network pharmacology and molecular docking to reveal the mechanism of Baihu Decoction in alleviating myocardial injury of heat stressed chicks. [PDF]

Poult Sci
Sun M, Liu C, Zhang P, Zhang H, Zhang H, Zhang T, Han C.   +6 more
europepmc   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein. [PDF]

Antioxidants (Basel)
Hu J, Feng J, Bai Y, Yao ZS, Wu XY, Hong XY, Lu GD, Xue K.   +7 more
europepmc   +1 more source

Integrate Molecular Docking and Animal Model Validation into the Research of the Effect and Potential Mechanism of Eupatilin Against Myocardial Ischemia/Reperfusion Injury

Yu‐Long Li, Xiang Li
openalex   +1 more source

DPImpute: A Genotype Imputation Framework for Ultra‐Low Coverage Whole‐Genome Sequencing and its Application in Genomic Selection

Advanced Science, Volume 12, Issue 16, April 24, 2025.
DPImpute is a two‐step pipeline that outperforms existing tools in whole‐genome SNP imputation, particularly under conditions of ultra‐low coverage sequencing, small sample sizes, and limited references. It enables precise imputation for single blastocyst cells, supporting genomic selection at the pre‐implantation stage.
Weigang Zheng, Wenlong Ma, Zhilong Chen, Chao Wang, Tao Sun, Wenjun Dong, Wenjing Zhang, Song Zhang, Zhonglin Tang, Kui Li, Yunxiang Zhao, Yuwen Liu   +11 more
wiley   +1 more source