Results 261 to 270 of about 2,926,121 (366)

Deep Learning Combined with Quantitative Structure‒Activity Relationship Accelerates De Novo Design of Antifungal Peptides

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Drug resistance remains a serious threat to human health and the planet's ecology. Using deep learning integrated with quantitative structure‒activity relationship, 49 highly active antifungal peptides are de novo designed. In vitro and in vivo studies demonstrate these peptides' potential to minimize the risk of resistance development in pathogens ...
Kedong Yin, Ruifang Li, Shaojie Zhang, Yiqing Sun, Liang Huang, Mengwan Jiang, Degang Xu, Wen Xu   +7 more
wiley   +1 more source

Exploring the active ingredients of Banzhilian and its mechanism of action on diabetic Gastric cancer based on network pharmacology. [PDF]

Sci Rep
Cao H, Song H, Zhou W, Lv X, Liu X, Xiang Z, Fu R, Cheng Y, Chen J, Wang S, Hu Y, Yan H, You W, Guo C, Chen B, Cao G, Wang W, Jia J.   +17 more
europepmc   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 17, May 8, 2025.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Neutrophil elastase binds at the central domain of extracellular Toll-like receptor 4: AI prediction, docking, and validation in disease model. [PDF]

Sci Rep
Ali A, Gaba L, Jetley S, Khan IA, Prakash P.   +4 more
europepmc   +1 more source

GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The study identifies MSN as a key regulator of proneural‐to‐mesenchymal transition (PMT) in GSCs, driving resistance to radiotherapy (RT) and temozolomide (TMZ) in glioblastoma (GBM). However, GNE‐317 specifically inhibits MSN, reverses PMT, resensitizes cells to therapy, and shows promise as a targeted strategy to overcome chemoradiotherapy resistance
Yong‐Chang Yang, Xing‐Yu Jin, Ling‐Ling Yang, Xing Xu, Yang Xie, Yi‐Ding Ai, Xin‐Chao Li, Ye‐Cheng Ma, Cheng‐Long Xu, Qi Li, Xiang‐Lian Ge, Tai‐Long Yi, Tao Jiang, Xiao‐Guang Wang, Ying‐Zhe Piao, Xun Jin   +15 more
wiley   +1 more source

Danhong Injection Inhibits Apoptosis in Ischemia/Reperfusion Injury Based on Network Pharmacology Analysis, Molecular Docking, and Experimental Verification. [PDF]

ACS Omega
Shi S, Lu Y, Long Q, Wu Y, Guo Y, Chen N, Wan H, Jin B.   +7 more
europepmc   +1 more source

DeepInterAware: Deep Interaction Interface‐Aware Network for Improving Antigen‐Antibody Interaction Prediction from Sequence Data

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Many thanks to you for your efforts on our manuscript. Here is a short summary and an eye‐catching color image of our manuscript. DeepInterAware is a sequence‐based framework that overcomes the challenge of scarce structure data in antigen‐antibody interactions.
Yuhang Xia, Zhiwei Wang, Feng Huang, Zhankun Xiong, Yongkang Wang, Minyao Qiu, Wen Zhang   +6 more
wiley   +1 more source

Interaction Between HAQ-STING Mutation and COPA: Protection Against COPA Syndrome. [PDF]

Cureus
Lehrer S.
europepmc   +1 more source

Metabolic Engineering of Corynebacterium glutamicum for High‐Level Production of 1,5‐Pentanediol, a C5 Diol Platform Chemical

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study develops an efficient biosynthesis system for 1,5‐pentanediol (1,5‐PDO) in Corynebacterium glutamicum, an important compound for industrial applications. By engineering the l‐lysine degradation pathway, 5‐hydroxyvaleric acid (5‐HV) is synthesized from glucose as a key intermediate.
Yu Jung Sohn, Se‐Yeun Hwang, Haeyoung Lee, Subeen Jeon, Ji Young Park, Jaehyung Kim, Donghyuk Kim, Ki Jun Jeong, Sang Yup Lee, Jeong Chan Joo, Jin‐Byung Park, Si Jae Park   +11 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source