Results 261 to 270 of about 135,313 (306)

Design, green synthesis and biological evaluation of fluorinated <i>N</i>-acyl sulfonamides as novel anti-inflammatory agents: an <i>in vivo</i> and <i>in silico</i> study. [PDF]

RSC Adv
Litim Z, Ben Abdeljaoued A, Abdelhamid A, Bouraoui A, Özdemir İ, Hamdi N, Soussi MA, Kraiem J.   +7 more
europepmc   +1 more source

Integrated New Approach Methodologies Reveal the Potential Role of 2,7-Dibromocarbazole in Parkinson's Disease via Monoamine Oxidase B Inhibition and Dopaminergic Dysfunction. [PDF]

Environ Sci Technol
Lu X, Luo Y, Peng P, Xing X, Xia W, Yin H, Li H, Xu S.   +7 more
europepmc   +1 more source

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Exploring the potential mechanism of Yixiang capsule immune-enhancing function based on Network Pharmacology, Molecular docking, and Animal function experiment

Combinatorial Chemistry & High Throughput Screening, 2022
Background: The Yixiang capsule with traditional Chinese herbs Cistanches Herba, Hedysarum multijugum Maxim,Fructus Ligustri Lucidi,and Fructus lycii are the main raw materials in a modern herbal medicine preparation containing corresponding bioactive ingredients after extraction and processing.
Jing, Wang, Weirong, Bai, Yan, Ding, Chenchen, Deng, Zhenzhong, Wang, Wei, Xiao   +5 more
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The long and short of it: A review of tail docking in farm animals

Applied Animal Behaviour Science, 2011
Tail docking involves amputating a portion of the tail for a variety of reasons. We review the scientific evidence for the rationale for tail docking, a description of the different methods used, the pain response to the procedure and the effectiveness of pain alleviation, and, finally, the alternatives to tail docking and policy regarding the practice.
Mhairi A. Sutherland, Cassandra B. Tucker   +1 more
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Assessment of palmitic acid toxicity to animal hearts and other major organs based on acute toxicity, network pharmacology, and molecular docking

Computers in Biology and Medicine, 2023
Palmitic acid is a common ingredient in many foods and traditional Chinese medicines. However, modern pharmacological experiments have shown that palmitic acid has toxic side effects. It can damage glomeruli, cardiomyocytes, and hepatocytes, as well as promote the growth of lung cancer cells. Despite this, there are few reports evaluating the safety of
Lijuan, Lv, Xiangpei, Wang, Hongmei, Wu
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Design, Synthesis, and Docking Study of Pyrimidine–Triazine Hybrids for GABA Estimation in Animal Epilepsy Models

Archiv der Pharmazie, 2017
A series of new pyrimidine–triazine hybrids (4a–t) was designed and synthesized, from which potent anticonvulsant agents were identified. Most of the compounds exhibited promising anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment with higher safety ...
Meeta Sahu, Nadeem Siddiqui, Mohd. Javed Naim, Ozair Alam, Mohammad Shahar Yar, Vidushi Sharma, Sharad Wakode   +6 more
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Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies

Current Gene Therapy, 2020
Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed to elucidate the beneficial role of voglibose via in-silico in vitro to in-vivo studies in improving the postprandial glycaemic state by protection against strokeprone type 2 diabetes.
Pooja, Shah, Vishal, Chavda, Snehal, Patel, Shraddha, Bhadada, Ghulam Md, Ashraf   +4 more
openaire   +2 more sources