Results 271 to 280 of about 2,926,121 (366)

Exploring the Potential Mechanism of Liupao Tea Using UPLC-Q-TOF/MS and Network Pharmacology. [PDF]

Pharmaceuticals (Basel)
Jia F, Yang Q, Yao L, Liu Y, Deng J, Leng J, Fan L, Hao E.   +7 more
europepmc   +1 more source

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Advanced Science, Volume 12, Issue 17, May 8, 2025.
The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu, Xing Zhao, Ting Jiang, Ningjuan Ouyang, Peilin Li, Wei Yang, Zhihe Zhao   +6 more
wiley   +1 more source

Antiviral activity of <i>Scutellaria baicalensis Georgi Extract</i> against Getah virus <i>in vivo</i> and <i>in vitro</i>. [PDF]

Front Vet Sci
Liu B, Wang Y, Shao L, Chen Y, Xu Z, Zhu L.   +5 more
europepmc   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

Advanced Science, Volume 12, Issue 15, April 17, 2025.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang, Kairui Yue, Simin Sun, Shengyuan Lu, Geng Jia, Yang Zha, Shuang Zhang, C. James Chou, Chenzhong Liao, Xiaoyang Li, Yajun Duan   +10 more
wiley   +1 more source

Transcriptome Analysis of Trigeminal Ganglion and Medullary Dorsal Horn in Mice to Identify Potential Targets for Pulpitis-Induced Pain. [PDF]

ACS Omega
Yu Z, Kang X, Si J, Ping R, Yan X, Wu X, Huang J, Wu LA.   +7 more
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

The efficacy of ophiopogonanone B in treating the cough in mice infected with <i>Mycoplasma pneumoniae</i>. [PDF]

Front Pharmacol
Liu NN, Guo BH, Wang L, Wang XX, Wang X, Meng YL, Tang GX, Wang WM.   +7 more
europepmc   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Machine learning-assisted analysis of serum metabolomics and network pharmacology reveals the effective compound from herbal formula against alcoholic liver injury. [PDF]

Chin Med
Ma J, Wei P, Xu X, Dong R, Deng X, Zhang F, Sun M, Li M, Liu W, Yao J, Cao Y, Ying L, Yang Y, Yang Y, Wu X, She G.   +15 more
europepmc   +1 more source

Identification of a Novel Substrate for eEF2K and the AURKA‐SOX8 as the Related Pathway in TNBC

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study reports that eukaryotic elongation factor 2 kinase (eEF2K) is a key regulator in promoting the progression of triple‐negative breast cancer (TNBC). Mechanistically, the authors identified AURKA as a novel substrate for eEF2K. In addition, the authors developed a new small molecule compound C4, which acts as a molecular glue for eEF2K and can
Xiaoya Wan, Rong Gong, Xiaobao Zhao, Yizhi Li, Tianjiao Shan, Changxin Zhong, Rongfeng Zhu, Zonglin Chen, Shilong Jiang, Linhao He, Shijun Cao, Sheng Tian, Jinming Yang, Na Ye, Wenjun Yi, Yan Cheng   +15 more
wiley   +1 more source