Results 281 to 290 of about 2,926,121 (366)

Evaluation of Lysophosphatidic Acid Effects and Its Receptors During Bovine Embryo Development. [PDF]

Int J Mol Sci
Yu B, Dai S, Cheng L, Lu Q, Liu Q, Chen H.   +5 more
europepmc   +1 more source

A Multi‐Task Self‐Supervised Strategy for Predicting Molecular Properties and FGFR1 Inhibitors

Advanced Science, Volume 12, Issue 13, April 3, 2025.
The overview of MTSSMol during pretraining. Initially, data augmentation techniques are applied to the raw input data to create various enhanced versions. These images are then fed into GNNs to extract latent features. Finally, the augmented data is utilized for two learning tasks. b.
Xin Yang, Yang Wang, Ye Lin, Mingxuan Zhang, Ou Liu, Jianwei Shuai, Qi Zhao   +6 more
wiley   +1 more source

Insight into the Role of the Aryl Hydrocarbon Receptor in Bovine Coronavirus Infection by an Integrated Approach Combining In Vitro and In Silico Methods. [PDF]

Microorganisms
Del Sorbo L, Acconcia C, Salvatore MM, Fusco G, Vasinioti V, Lucente MS, Zhu L, Pratelli A, Russo L, Andolfi A, Iacovino R, Fiorito F.   +11 more
europepmc   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Inhibitory effect of luteolin on the metabolism of vandetanib <i>in vivo</i> and <i>in vitro</i>. [PDF]

Front Pharmacol
Shen Y, Hong F, Wu H, Chen X, Xia H, Xu RA, Lin G, Shi L.   +7 more
europepmc   +1 more source

Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3‐O‐UGT2

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This work reveals the crystal structures of Pq3‐O‐UGT2 with its substrates (Rh2 or F2), unveiling an Nα5‐oriented binding pocket and unique linker conformation. Hydrophobic interactions are crucial for substrate recognition, while hydrogen bonds enhance specificity for F2. This study enhances the understanding of ginsenoside UGTs' substrate recognition
Qiushuang Ji, Yirong Liu, Huanyu Zhang, Yan Gao, Yixin Ding, Yuanyuan Ding, Jing Xie, Jianyu Zhang, Xinghua Jin, Bin Lai, Cheng Chen, Juan Wang, Wenyuan Gao, Kunrong Mei   +13 more
wiley   +1 more source

<i>Patrinia scabiosaefolia</i> L. Modulates the Intestinal Microecology to Treat DSS-Induced Ulcerative Colitis: UHPLC-OE-MS/MS, Network Pharmacology, and Experimental Validation. [PDF]

Foods
Zhang L, Liu X, Xu M, Cheng X, Li N, Xu H, Feng Y, Guan T, Xiao L.   +8 more
europepmc   +1 more source

Customization of Ethylene Glycol (EG)‐Induced BmoR‐Based Biosensor for the Directed Evolution of PET Degrading Enzymes

Advanced Science, Volume 12, Issue 13, April 3, 2025.
PET degrading enzymes are evolved employing a novel fluorescence high‐throughput screening tool via a performance‐improved ethylene glycol (EG)‐induced BmoR‐based biosensor modified by TF engineering. PET waste is completely depolymerized into its basic units at moderate temperatures.
Min Li, Zhenya Chen, Wuyuan Zhang, Tong Wu, Qingsheng Qi, Yi‐Xin Huo   +5 more
wiley   +1 more source

<i>Pulsatilla koreana</i> Nakai Extract Attenuates Atopic Dermatitis-like Symptoms by Regulating Skin Barrier Factors and Inhibiting the JAK/STAT Pathway. [PDF]

Int J Mol Sci
Kim HJ, Park M, Jang S, Song HK, Lee SK, Kim T.   +5 more
europepmc   +1 more source

α‐Lipoic Acid Ameliorates Arsenic‐Induced Lipid Disorders by Promoting Peroxisomal β‐Oxidation and Reducing Lipophagy in Chicken Hepatocyte

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Arsenic‐induced liver injury poses a serious threat to human health and poultry industry. This study finds that α‐lipoic acid alleviates arsenic‐induced lipid accumulation and enhances lipophagy by targeting SIRT1, ameliorating mitochondrial damage, enhancing peroxisomal β‐oxidation.
Yangfei Zhao, Mingyue Guo, Ting Pei, Chenqi Shang, Yirong Chen, Liying Zhao, Yiguang Lu, Chen Liang, Jundong Wang, Jianhai Zhang   +9 more
wiley   +1 more source