Results 291 to 300 of about 2,947,274 (350)

Computational discovery of potential therapeutic agents against brain-eating amoeba (Naegleria fowleri). [PDF]

PLoS One
Zattoni J, Ludueña RF, Aminpour M, Tuszynski JA.   +3 more
europepmc   +1 more source

In Vivo and In Silico Evaluation of Analgesic and Hypoglycemic Activities of Methanolic Extract of <i>Codariocalyx gyroids</i>. [PDF]

Food Sci Nutr
Sultana N, Hasan M, Arabi II, Islam Z, Julhash J, Hani U, Sikder A, Khanam MA, Ripon A.   +8 more
europepmc   +1 more source

Yiqi Yangyin Tongluo Recipe Alleviates Diabetic Kidney Disease Through AGE-RAGE Signalling Axis. [PDF]

Diabetes Metab Syndr Obes
Yu R, Wu R, Chen T, Zhang Y, Chen X.
europepmc   +1 more source

Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation. [PDF]

Discov Oncol
Mei X, Zhang J, Chen L, Wang F.
europepmc   +1 more source

Design, Synthesis, and Docking Study of Pyrimidine–Triazine Hybrids for GABA Estimation in Animal Epilepsy Models

Archiv der Pharmazie, 2017
A series of new pyrimidine–triazine hybrids (4a–t) was designed and synthesized, from which potent anticonvulsant agents were identified. Most of the compounds exhibited promising anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment with higher safety ...
Meeta Sahu, Nadeem Siddiqui, Mohd. Javed Naim, Ozair Alam, Mohammad Shahar Yar, Vidushi Sharma, Sharad Wakode   +6 more
semanticscholar   +5 more sources

Assessment of palmitic acid toxicity to animal hearts and other major organs based on acute toxicity, network pharmacology, and molecular docking

Computers in Biology and Medicine, 2023
Palmitic acid is a common ingredient in many foods and traditional Chinese medicines. However, modern pharmacological experiments have shown that palmitic acid has toxic side effects. It can damage glomeruli, cardiomyocytes, and hepatocytes, as well as promote the growth of lung cancer cells. Despite this, there are few reports evaluating the safety of
Lijuan Lv, Xiangpei Wang, Hongmei Wu
semanticscholar   +4 more sources

Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies

Current Gene Therapy, 2020
Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed to elucidate the beneficial role of voglibose via in-silico in vitro to in-vivo studies in improving the postprandial glycaemic state by protection against strokeprone type 2 diabetes.
Pooja Shah, Vishal Chavda, Snehal S. Patel, Shraddha V. Bhadada, Ghulam Md Ashraf   +4 more
semanticscholar   +4 more sources

α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study

Chemico-Biological Interactions, 2016
The anti-hyperalgesic effect of the complex containing α-terpineol (αTPN) and β-cyclodextrin (βCD) was analyzed in a non-inflammatory chronic muscle pain model, as well as its mechanism of action through docking study for a possible interaction with receptors.
Makson Gleydson Brito de Oliveira, Renan Guedes de Brito, Priscila L. Santos, Heitor G. Araújo-Filho, Jullyana de Souza Siqueira Quintans, Paula dos Passos Menezes, Mairim Russo Serafini, Yasmim Maria Barbosa Gomes de Carvalho, Juliane C. Silva, Jackson Roberto Guedes da Silva Almeida, Luciana Scotti, Marcus Tullius Scotti, S. Saravanan, Parimelazhagan Thangaraj, Adriano Antunes de Souza Araújo, Lucindo José Quíntans-Júnior   +15 more
semanticscholar   +5 more sources

The long and short of it: A review of tail docking in farm animals

Applied Animal Behaviour Science, 2011
Tail docking involves amputating a portion of the tail for a variety of reasons. We review the scientific evidence for the rationale for tail docking, a description of the different methods used, the pain response to the procedure and the effectiveness of pain alleviation, and, finally, the alternatives to tail docking and policy regarding the practice.
Mhairi A. Sutherland, Cassandra B. Tucker   +1 more
openalex   +3 more sources