Results 291 to 300 of about 2,926,121 (366)

Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites. [PDF]

Drug Des Devel Ther
Zhao X, Su S, Zhou J, Gao J, Tang X, Wen B.   +5 more
europepmc   +1 more source

Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β‐Adrenergic Activation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study explores the roles of cardiomyocyte‐ and cardiac fibroblast‐specific EP4 in isoproterenol‐induced cardiac fibrosis. The findings reveal that EP4 inhibition improves diastolic function and reduces fibrosis by modulating TGF‐β1 signaling and extracellular matrix protein production.
Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao, Yashuo Wang, Haonan Li, Yinghui Qi, Yongliang Yang, Lihong Chen, Youfei Guan, Xiaoyan Zhang   +16 more
wiley   +1 more source

Curcumin Analog J7 Attenuates Liver Fibrosis and Metabolic Dysregulation in a Rat Model of Type 2 Diabetes via Modulation of TGF-β/Smad and NF-κB/BCL-2/BAX Pathways. [PDF]

Drug Des Devel Ther
Ma J, Chen W, Vaishnani DK, Wang C, Xue S, Yang Q, Tong Y, Lei N, Zhao Z, Ying F.   +9 more
europepmc   +1 more source

A Hf(IV)‐Coordinated NIR‐II Fluorescence “Turn‐On” Nanoprobe for Precise Imaging‐Guided Surgery in Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Based on the FDA‐approved fluorescent dye ICG, a Hf(IV)‐coordinated NIR‐II fluorescence “turn‐on” nanoprobe is constructed. This ultrasensitive nanoprobe can effectively accumulate in tumor sites and recover the fluorescence of ICG specifically in tumor microenvironment, accurately identifying submillimeter‐sized tumors with high sensitivity for real ...
Yueyang He, Jinyan Lin, Jingwen Bai, Xiao Shen, Kangliang Lou, Yuanyuan Zhu, Zishan Qiao, Weiling Chen, Yang Li, Xiaolong Liu, Guojun Zhang   +10 more
wiley   +1 more source

Synergistic Antibacterial Activity of Amorolfine Combined with Colistin Against <i>Acinetobacter baumannii</i>. [PDF]

Int J Mol Sci
Lin T, Liu S, Chen X, Gao F, Liu L, Chen D, Yin Y.   +6 more
europepmc   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Bioinformatics-Based Analysis of Ferroptosis-Related Biomarkers and the Prediction of Drugs Affecting the Adipogenic Differentiation of MSCs. [PDF]

Biomedicines
Jin J, Yuan Z, Wang X, Li Q, Zhang Y, Zhang Y, Ji P, Wu Y, Wang P, Liu W.   +9 more
europepmc   +1 more source

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

Indirubin attenuates sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages. [PDF]

Front Pharmacol
Li Y, Wan C, Li F, Xin G, Wang T, Zhou Q, Wen T, Li S, Chen X, Huang W.   +9 more
europepmc   +1 more source

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source