Results 301 to 310 of about 2,947,274 (350)

Exploring the potential mechanism of Yixiang capsule immune-enhancing function based on Network Pharmacology, Molecular docking, and Animal function experiment

Combinatorial Chemistry & High Throughput Screening, 2022
Background: The Yixiang capsule with traditional Chinese herbs Cistanches Herba, Hedysarum multijugum Maxim,Fructus Ligustri Lucidi,and Fructus lycii are the main raw materials in a modern herbal medicine preparation containing corresponding bioactive ingredients after extraction and processing.
Jing Wang, Weirong Bai, Yan Ding, Chenchen Deng, Zhenzhong Wang, Wei Xiao   +5 more
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UPLC-Q-TOF-MS/MS Combined with Network Pharmacology, Molecular Docking, and Animal Verification Reveals the Mechanism of Insomnia Treatment by Shen Qi Wu Wei Zi capsules

Combinatorial Chemistry & High Throughput Screening, 2023
Background: Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat insomnia; however, the potential therapeutic mechanism is still unclear. Objective: This study aimed to investigate the mechanism underlying the therapeutic effects of the Shen Qi Wu Wei Zi capsules on insomnia.
Fengyun Bai, Jie Wang, Xia Ning, Ying Sun, Yundong Xie, Chongbo Zhao, Jing Sun, Xiaofei Zhang   +7 more
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Docking analysis of circulating CTX-M variants in multi-drug resistant, beta-lactamase and biofilm-producing E. coli isolated from pet animals and backyard livestock

Microbial Pathogenesis, 2022
The generation of antimicrobial-resistant bacteria largely depends on the use of antimicrobials not only in humans but also in pet animals and livestock. The present study was conducted to detect the occurrence of beta-lactamase and biofilm-producing- E.coli in healthy pet and backyard livestock. The study also intended on molecular docking experiments
Abhiroop Banerjee, Surajit Pal, Purba Goswami, K. Batabyal, Siddhartha Narayan Joardar, Samir Dey, D.P. Isore, Tapan Kumar Dutta, Samiran Bandyopadhyay, Indranil Samanta   +9 more
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Identification and molecular mechanism of the anti-inflammatory effect of sea cucumber peptides: Network pharmacology, molecular docking and animal experiments

International Journal of Biological Macromolecules
Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which there is currently no efficacious therapeutic drug with fewer side effects. Therefore, the development of approaches for the prevention of UC from natural food sources is urgently needed. In this study, mice were pre-fed with sea cucumber peptides prior to dextran sodium sulfate (
Jianhui Feng, Haojie Wang, Xinyue Luo, Lina Zhang, Peng Zhou   +4 more
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Synthetic Derivates of Progesterone Ameliorate Scopolamine-Induced Cognitive Deficits in Animal Models: Antioxidant, Enzyme Inhibitory, Molecular Docking and Behavioral Correlates

Current Neuropharmacology
Background: Alzheimer's disease (AD) is a neurological disorder characterized by cognitive decline and behavioral turbulence and is anticipated to badly affect the patient's quality of life. Previous studies revealed the neuroprotective effects of progesterone, so this study aimed to appraise the neuroprotective potentials of new derivatives of ...
Asif Nawaz, Abdul Sadiq, Nasreena Bashir, Umer Rashid, Farhat Ullah, Shahbaz Khan, Farman Ullah, Muhammad Inam Khan, Muhammad Ayaz   +8 more
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Analysis of Small Ischemic Lesions in the Examinees of a Brain Dock and Neurological Examination of Animals Subjected to Cortical or Basal Ganglia Photothrombotic Infarction

, 2016
We analyzed cases of small brain ischemic lesions found in examinees of a brain dock (neurological health screening center). Small cerebral infarction was found in 17 % of the examinees (733 cases). White matter lesions were found in 24 %. Infarctions were located in the cortex or subcortical white matter in 31 % and in the basal ganglia in 44 % of ...
Toshihiko Kuroiwa, Hitoshi Tabata, Guohua Xi, Ya Hua, Timothy Schallert, Richard F. Keep   +5 more
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Exploration of the Mechanism of Tanre Qing Injection in Treating Acute Respiratory Distress Syndrome through Network Pharmacology, Molecular Docking, and Animal Experiments

Combinatorial Chemistry & High Throughput Screening
Objective: This study aimed to explore the active components and potential mechanism of Tanre Qing Injection (TRQI) in the treatment of Acute Respiratory Distress Syndrome (ARDS) using network pharmacology, molecular docking, and animal experiments.
Liang Wang, Guo‐Liang Lu, Tianyu Cheng, Shuangquan Wen, Witz Ma, Yixuan Li   +5 more
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Mechanisms of the Compound of Magnoliae Flos and Xanthii Fructus Essential Oils for the Treatment of Allergic Rhinitis based on the Integration of Network Pharmacology, Molecular Docking, and Animal Experiment

Combinatorial Chemistry & High Throughput Screening
Aim and Objective: Magnoliae Flos (Chinese name: Xin-Yi) and Xanthii Fructus (Chinese name: Cang-Er-Zi) are Chinese herbal medicines and have been used to treat allergic rhinitis (AR). However, the therapeutic effect, active ingredients, and probable processes of a compound of Magnoliae Flos and Xanthii Fructus in the form of essential oils (CMFXFEO ...
Tao Lu, Yuqin Yang, Zhen-Lin Yang, Ziyi Liu, Miao Li, Zhao‐Yang Lu, Ting Gong, Jincheng Zhang   +7 more
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[Network pharmacology, molecular docking, and animal experiments reveal mechanism of Zhizhu Decoction in regulating macrophage polarization to reduce adipose tissue inflammation in obese children].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Network pharmacology and molecular docking were employed to predict the mechanism of Zhizhu Decoction in regulating macrophage polarization to reduce adipose tissue inflammation in obese children, and animal experiments were then carried out to validate the prediction results.
Yongkai Yin, Chen Niu, Liting Liang, Dan Mo, Tian Gao, Yanhong Qin, Xiaoning Yan   +6 more
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Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations.

Journal of Physiology and Pharmacology, 2023
Resveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored.
A. Parveen, F. Alqahtani, S. Javaid, W. Ashraf, F. Siddique, R. Rawat, M. Rasool, T. Ahmad, F. Alasmari, I. Imran   +9 more
semanticscholar   +1 more source