Results 181 to 190 of about 3,160,114 (308)

Integration of epidemiological surveys, network pharmacology, and molecular docking simulation to explore the potential key targets of propofol-induced euphoria. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Wang L, Liao Z, Qiu G, Yang B.
europepmc   +1 more source

Metal Chelates of Sulfafurazole Azo Dye Derivative: Synthesis, Structure Affirmation, Antimicrobial, Antitumor, DNA Binding, and Molecular Docking Simulation. [PDF]

Bioinorg Chem Appl, 2023
El-Ghamry HA, Al-Ziyadi RO, Alkhatib FM, Takroni KM, Khedr AM.   +4 more
europepmc   +1 more source

Hydrodynamic analysis of AUV underwater docking with a cone-shaped dock under ocean currents

, 2014
This paper investigates the hydrodynamics issues that are associated with AUVs (autonomous underwater vehicles) as they approach a cone-shaped dock, which is proposed by most AUV docking systems for the AUVs protection and simplification.
Wu LH(吴利红), Yan P(闫鹏), Su, Shaojuan, Li YP(李一平), Qin, Yu   +4 more
core  

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

Correlation Between In Silico Docking/Simulation Results and In Vitro MAGL Inhibition Potency of Selected Triterpenes. [PDF]

Curr Issues Mol Biol
Masocha W, Khedr MA.
europepmc   +1 more source

Evaluation of Activity of Sesquiterpene Lactones and Chicory Extracts as Acetylcholinesterase Inhibitors Assayed in Calorimetric and Docking Simulation Studies. [PDF]

Nutrients, 2022
Jaśkiewicz A, Budryn G, Carmena-Bargueño M, Pérez-Sánchez H.   +3 more
europepmc   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Evaluation of <i>Quercus infectoria</i> Phytoconstituents Against Oral Cancer: Network Pharmacology, Docking Simulation, and In Vitro Cytotoxicity Assay. [PDF]

Food Sci Nutr
Kamaria P, Tiwari P, Prabhakaran P, Bhardwaj S, Kolachi K, Thapa S.   +5 more
europepmc   +1 more source

Homology modeling and molecular docking simulation of martentoxin as a specific inhibitor of the BK channel. [PDF]

Ann Transl Med, 2022
Yang C, Yang Z, Tong K, Wang J, Yang W, Yu R, Jiang F, Ji Y.   +7 more
europepmc   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source