Results 1 to 10 of about 45,442 (272)
Molecules, 2021 Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai +4 more
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Molecules, 2023 Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with ...
Li Lu +5 more
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Comparative Study of High-throughput Screening Models for Anti-hyperpigmentation Compounds
Brazilian Archives of Biology and Technology, 2022 The mushroom tyrosinase assay, B16-F10 mouse melanoma cell model, and zebrafish model are frequently used for high-throughput screening and are widely used for developing anti-hyperpigmentation compounds, although these systems cannot be compared.
Tingwei Sun +7 more
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Computational and Structural Biotechnology Journal, 2022 As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-b]thiazol-3(2H)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template.
Heejeong Choi +11 more
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In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template
Computational and Structural Biotechnology Journal, 2021 The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized.
Inkyu Choi +11 more
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Antioxidant Capacity of Black Tea Obtained Using Tyrosinase and Tannase Treatment
Indonesian Food and Nutrition Progress, 2023 Black tea has a lower antioxidant capacity than other teas, such as green tea, white tea, and oolong tea. Tannase and tyrosinase can be used as a treatment to improve the quality of black tea infusion.
Fiyan Maulana Rajendra +2 more
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The nature of tyrosinase [PDF]
Biochemical Journal, 1931 The view that tyrosinase is a mixture of a number of components has been held by several investigators. Haehn [1920] reported that potato tyrosinase lost its activity on dialysis or ultrafiltration, but regained it on addition of the ultrafiltrate or boiled juice. He concluded that the activator was inorganic in nature.
D, Narayanamurti, C V, Ramaswami
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Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins [PDF]
Chemistry – A European Journal, 2017 AbstractMelanin is the main pigment responsible for the color of human skin, hair and eye. Its biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase‐related proteins TYRP1 and TYRP2. The difficulty of isolating pure and homogeneous proteins from endogenous sources has hampered their study, and resulted in many ...
Xuelei Lai +3 more
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Molecules, 2023 Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases.
Jianping Li +5 more
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Molecules, 2021 To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve (Z)-5-(substituted benzylidene)-4-thioxothiazolidin-2-
Heejeong Choi +15 more
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