Results 31 to 40 of about 45,442 (272)

Inhibition of Tyrosinase by Mercury Chloride: Spectroscopic and Docking Studies

Frontiers in Pharmacology, 2020
Inorganic mercury compounds have been used in skin-lightening products since ancient times. Although a previous study demonstrated that mercury impeded the transfer of Cu2+ to the apotyrosinase, the effect of mercury on tyrosinase is still unclear.
Jianmin Chen, Jianmin Chen, Yaling Ye, Mengnan Ran, Qinglian Li, Zhipeng Ruan, Zhipeng Ruan, Nan Jin, Nan Jin   +8 more
doaj   +1 more source

tris-Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations. [PDF]

Chem Biodivers
New tris‐Schiff base derivatives of marketed accessible flurbiprofen were synthesised in better yields through multi‐step reactions. Structures of these compounds were deduced through 13C‐NMR and 1H‐NMR spectroscopic methods and finally screened for their in vitro tyrosinase inhibitory potential.
Alam A, Ayaz M, Zainab, Khan M, Elhenawy AA, Rehman NU, Rahman SU, Ali M, Al-Harrasi A, Ahmad M.   +9 more
europepmc   +2 more sources

Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase

Antioxidants, 2022
Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes ...
Joonhyeok Choi, Trilok Neupane, Rishiram Baral, Jun-Goo Jee   +3 more
doaj   +1 more source

Tyrosinase-Mediated Oxidative Coupling of Tyrosine Tags on Peptides and Proteins

, 2020
Oxidative coupling (OC) through o-quinone intermediates has been established as an efficient and site-selective way to modify protein N-termini and the unnatural amino acid p-aminophenylalanine (paF).
Alan M. Marmelstein, Casey S. Mogilevsky (8537382), Casey S. Mogilevsky, Johnathan C. Maza, Alan M. Marmelstein (1861294), Marco J. Lobba, Marco J. Lobba (6056552), Matthew B. Francis, Matthew B. Francis (425831), Daniel D. Brauer (6383321), Daniel D. Brauer, Johnathan C. Maza (3385469)   +11 more
core   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor

Frontiers in Chemistry
Tyrosinase is one important rate limiting enzyme in melanin synthesis, directly affecting the melanin synthesis. Quercetagetin is one active ingredient from marigold.
Faliang Liang
doaj   +1 more source

Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor

Molecules, 2021
Tyrosinase is a copper-containing monooxygenase catalyzing the O-hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes.
Hanaa Salah Maamoun, Gamal H. Rabie, Ibrahim Shaker, Bothaina A. Alaidaroos, Ashraf S. A. El-Sayed   +4 more
doaj   +1 more source

Tyrosinase Inhibitors: A Perspective

Molecules, 2023
Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have made it to the market in the cosmetics industry, but their use has been limited due to conflicting ...
Mason A. Baber, Cole M. Crist, Noah L. Devolve, James D. Patrone   +3 more
openaire   +3 more sources

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as ...
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam   +2 more
doaj   +1 more source

The Hypopigmentation Mechanism of Tyrosinase Inhibitory Peptides Derived from Food Proteins: An Overview

Molecules, 2022
Skin hyperpigmentation resulting from excessive tyrosinase expression has long been a problem for beauty lovers, which has not yet been completely solved.
Yuqiong Song, Shengjun Chen, Laihao Li, Yaoxun Zeng, Xiao Hu   +4 more
doaj   +1 more source