Results 31 to 40 of about 54,266 (256)

The nature of tyrosinase [PDF]

Biochemical Journal, 1931
The view that tyrosinase is a mixture of a number of components has been held by several investigators. Haehn [1920] reported that potato tyrosinase lost its activity on dialysis or ultrafiltration, but regained it on addition of the ultrafiltrate or boiled juice. He concluded that the activator was inorganic in nature.
D, Narayanamurti, C V, Ramaswami
openaire   +2 more sources

Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters

Molecules, 2023
Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases.
Jianping Li, Xiaofeng Min, Xi Zheng, Shaohua Wang, Xuetao Xu, Jinbao Peng   +5 more
doaj   +1 more source

Novel Anti-Melanogenic Compounds, (Z)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights

Molecules, 2021
To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve (Z)-5-(substituted benzylidene)-4-thioxothiazolidin-2-
Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, In-Soo Yoon, Hwayoung Yun, Min-Soo Kim, Jin-Wook Yoo, Yunjin Jung, Pusoon Chun, Hyung Ryong Moon   +15 more
doaj   +1 more source

Determination of tyrosinase-cyanidin-3-O-glucoside and (−/+)-catechin binding modes reveal mechanistic differences in tyrosinase inhibition

Scientific Reports, 2021
Tyrosinase, exquisitely catalyzes the phenolic compounds into brown or black pigment, inhibition is used as a treatment for dermatological or neurodegenerative disorders. Natural products, such as cyanidin-3-O-glucoside and (−/+)-catechin, are considered
Kyung Eun Lee, Shiv Bharadwaj, Amaresh Kumar Sahoo, Umesh Yadava, Sang Gu Kang   +4 more
doaj   +1 more source

Characterization of Tyrosinase Inhibitors in Dryopteris crassirhizoma Rhizome Using a Combination of High-Speed Counter-Current Chromatography, Affinity-Based Ultrafiltration, and Liquid Chromatography–Tandem Mass Spectrometry

Frontiers in Nutrition, 2022
Dryopteris crassirhizoma rhizome (DCR) inhibits melanin production in B16F10 melanoma cells and tyrosinase activity. The melanin content and tyrosinase activity of DCR-treated zebrafish embryos were determined to evaluate the in vivo inhibitory effect of
Zhiqiang Wang, Ning Wang, Dandan Han, Hongyuan Yan, Hongyuan Yan   +4 more
doaj   +1 more source

In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives

Computational and Structural Biotechnology Journal, 2019
Tyrosinase is a key enzyme responsible for melanin biosynthesis and is effective in protecting skin damage caused by ultraviolet radiation. As part of ongoing efforts to discover potent tyrosinase inhibitors, we systematically designed and synthesized ...
Hee Jin Jung, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon   +6 more
doaj   +1 more source

Phlorotannins Derived From the Brown Alga as Tyrosinase Inhibitors

Natural Product Communications, 2021
Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase
Hideyuki Kurihara, Kazuki Kujira
doaj   +1 more source

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

Nature Communications, 2019
In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD.
Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, J. Bové, M. Martínez-Vicente, Annabelle Parent, Marta González-Sepúlveda, N. Peñuelas, A. Torra, Beatriz Rodríguez-Galván, A. Ballabio, T. Hasegawa, A. Bortolozzi, E. Gelpí, M. Vila   +15 more
semanticscholar   +1 more source

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

Molecules, 2018
In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities.
Chang Seok Kim, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hee Jin Jung, Hyung Ryong Moon   +7 more
doaj   +1 more source

A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[d]thiazoles: In Vitro and In Silico Insights

Antioxidants, 2022
Sixteen compounds bearing a benzothiazole moiety were synthesized as potential tyrosinase inhibitors and evaluated for mushroom tyrosinase inhibitory activity.
YeJi Hwang, Jieun Lee, Hee Jin Jung, Sultan Ullah, Jeongin Ko, Yeongmu Jeong, Yu Jung Park, Min Kyung Kang, Hwayoung Yun, Min-Soo Kim, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon   +12 more
doaj   +1 more source