Results 31 to 40 of about 39,961 (248)

Tyrosinase-Loaded Multicompartment Microreactor toward Melanoma Depletion [PDF]

, 2019
Melanoma is malignant skin cancer occurring with increasing prevalence with no effective treatment. A unique feature of melanoma cells is that they require higher concentrations of ltyrosine (l-tyr) for expansion than normal cells.
Maria Godoy-Gallardo (1659781), Cédric Labay, Leticia Hosta-Rigau, Labay, Cédric Pierre, Maria Godoy-Gallardo, Leticia Hosta-Rigau (1269717), Cédric Labay (3742456), Gallardo, Maria Godoy, Hosta-Rigau, Leticia   +8 more
core   +1 more source

Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase

Antioxidants, 2022
Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes ...
Joonhyeok Choi, Trilok Neupane, Rishiram Baral, Jun-Goo Jee   +3 more
doaj   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor

Frontiers in Chemistry
Tyrosinase is one important rate limiting enzyme in melanin synthesis, directly affecting the melanin synthesis. Quercetagetin is one active ingredient from marigold.
Faliang Liang
doaj   +1 more source

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as ...
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam   +2 more
doaj   +1 more source

Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor

Molecules, 2021
Tyrosinase is a copper-containing monooxygenase catalyzing the O-hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes.
Hanaa Salah Maamoun, Gamal H. Rabie, Ibrahim Shaker, Bothaina A. Alaidaroos, Ashraf S. A. El-Sayed   +4 more
doaj   +1 more source

Tyrosinase-Mediated Oxidative Coupling of Tyrosine Tags on Peptides and Proteins

, 2019
We report a strategy for chemical protein modification by using tyrosinase enzymes to oxidize exposed tyrosine residues on protein N or C-termini. We explore the chemical space for coupling partners in this reaction and find combinations that can proceed
Alan Marmelstein (5803390), Daniel D. Brauer (5797553), Casey S. Mogilevsky (7466378), Johnathan Maza (5803382), Marco Lobba (7466247), Matthew Francis (5811119)   +5 more
core   +2 more sources

From Fish Scale Gelatin to Tyrosinase Inhibitor: A Novel Peptides Screening Approach Application

Frontiers in Nutrition, 2022
Bioaffinity ultrafiltration combined with LC-Orbitrap-MS/MS was applied for the first time to achieve rapid screening and identification of tyrosinase inhibitory peptides (TYIPs) from grass carp scale gelatin hydrolysates.
Zi-Zi Hu, Xiao-Mei Sha, Lu Zhang, Min-Jun Zha, Zong-Cai Tu, Zong-Cai Tu   +5 more
doaj   +1 more source

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions.

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Christopher Cheng, Elena Sviderskaya, Sviderskaya, EV, Lam, RY, Zhi-Xiu Lin, Lin, ZX, Rosanna Lam, Cheng, CH   +7 more
core   +1 more source

Inhibitory Effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on Tyrosinase Activity and α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells

Life, 2023
Melanogenesis involves a synthesis of melanin pigment and is regulated by tyrosinase. The addition of whitening agents with tyrosinase-inhibiting properties in cosmetics is becoming increasingly important.
Pradtana Choosuwan, Jantana Praiboon, Korawinwich Boonpisuttinant, Anirut Klomjit, Narongrit Muangmai, Rapeeporn Ruangchuay, Anong Chirapart   +6 more
doaj   +1 more source