Results 51 to 60 of about 45,442 (272)
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
TYROSINASE AND PLANT RESPIRATION [PDF]
Journal of General Physiology, 1943 The evidence presented in this paper supports the conclusion that at least 85 per cent of the oxygen uptake of the respiring tissue of potato tuber enters the chemistry of the cell by way of a tyrosinase-catalyzed oxidation. The qualitative aspects of this conclusion are in agreement with the claim made by Boswell and Whiting.
D, Baker, J M, Nelson
openaire +2 more sources
Tyrosinase-Mediated Oxidative Coupling of Tyrosine Tags on Peptides and Proteins
, 2019 We report a strategy for chemical protein modification by using tyrosinase enzymes to oxidize exposed tyrosine residues on protein N or C-termini. We explore the chemical space for coupling partners in this reaction and find combinations that can proceed
Alan Marmelstein (5803390) +5 more
core +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Analysis of the Cre-mediated recombinant expression in embryonic Ai14;RPE-Tyrosinase-CreErT2 mice.
, 2018 A: Fluorescent flatmount image showing the uniform distribution of tdTomato expressing cells throughout the RPE of an E17.5 Ai14;RPE-Tyrosinase-CreErT2 embryo. Outline of the RPE indicated by the solid line.
Kapil Bharti (153586) +5 more
core +1 more source
Natural Product CommunicationsObjective The aim of this study was to assess the ability of polyphenolic extracts from different kiwifruit genotypes to affect tyrosinase enzyme activity and determine potential relationships between tyrosinase inhibition and polyphenolic composition ...
Andrew M. Carroll +5 more
doaj +1 more source
Tyrosinase-Loaded Multicompartment Microreactor toward Melanoma Depletion [PDF]
, 2019 Melanoma is malignant skin cancer occurring with increasing prevalence with no effective treatment. A unique feature of melanoma cells is that they require higher concentrations of ltyrosine (l-tyr) for expansion than normal cells.
Maria Godoy-Gallardo (1659781) +8 more
core +1 more source
Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray
ChemFoodChem, EarlyView.This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi +2 more
wiley +1 more source
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [PDF]
PeerJ, 2018 Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases.
Qi Li +7 more
doaj +2 more sources
, 2017 The exposure of human skin to 4-(4-hydroxyphenyl)-2-butanone (raspberry ketone, RK) is known to cause chemical/occupational leukoderma. RK has a structure closely related to 4-(4-hydroxyphenyl)-2-butanol (rhododendrol), a skin whitening agent that was ...
Shosuke Ito (55670) +4 more
core +1 more source