Results 51 to 60 of about 53,271 (260)

Catalysis-based specific detection and inhibition of tyrosinase and their application

Journal of Pharmaceutical Analysis, 2020
Tyrosinase is an important enzyme in controlling the formation of melanin in melanosome, and plays a key role in the pigmentation of hair and skin. The abnormal expression or activation of tyrosinase is associated with several diseases such as albinism ...
Yunwei Qu, Qing Zhan, Shubo Du, Yang Ding, Bin Fang, Wei Du, Qiong Wu, Haidong Yu, Lin Li, Wei Huang   +9 more
semanticscholar   +1 more source

The Effect of Polyphenolic Extracts from 10 New Zealand Kiwifruit Cultivars in Inhibiting Tyrosinase Enzyme Activity

Natural Product Communications
Objective The aim of this study was to assess the ability of polyphenolic extracts from different kiwifruit genotypes to affect tyrosinase enzyme activity and determine potential relationships between tyrosinase inhibition and polyphenolic composition ...
Andrew M. Carroll, Gregory M. Sawyer, Laurie Favre, Tony K. McGhie, Dominic Lomiwes, Roger D. Hurst   +5 more
doaj   +1 more source

A Mononuclear Scenario for the Copper‐Catalyzed Monooxygenation of Phenolic Substrates

Chemistry – A European Journal, EarlyView.
ABSTRACT Whereas a dinuclear pathway applies to the monooxygenation of phenols by the type 3 copper enzyme tyrosinase, a mononuclear pathway has been identified for the same reaction in corresponding small‐molecule systems. DFT calculations of five copper model complexes reveal that the latter mechanism is energetically feasible, identifying all ...
Alexander Koch, Antony Memboeuf, Felix Tuczek, Tobias A. Engesser   +3 more
wiley   +1 more source

Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase.

Food Research International, 2018
Four economically important brown algae species (Ascophyllum nodosum, Laminaria japonica, Lessonia trabeculate and Lessonia nigrecens) were investigated for phenolic compound extraction and evaluated for their antioxidant, anti-hyperglycemic, and ...
Yuan Yuan, Jian Zhang, Jiajun Fan, J. Clark, Peili Shen, Yiqiang Li, Chengsheng Zhang   +6 more
semanticscholar   +1 more source

Anti melanogenic effect of Croton roxburghii and Croton sublyratus leaves in α-MSH stimulated B16F10 cells

Journal of Traditional and Complementary Medicine, 2019
Croton roxburghii and Croton sublyratus have been used as skin treatments in traditional medicine. The objective of the present study was to investigate the antimelanogenic effect of ethanol extracts of Croton roxburghii (CRE) and Croton sublyratus (CSE)
Moragot Chatatikun, Takeshi Yamauchi, Kenshi Yamasaki, Setsuya Aiba, Anchalee Chiabchalard   +4 more
doaj   +1 more source

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Droplet, EarlyView.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Tyrosinase-catalyzed Oxidation of Fluorophenols [PDF]

Journal of Biological Chemistry, 2002
The activity of the type 3 copper enzyme tyrosinase toward 2-, 3-, and 4-fluorophenol was studied by kinetic methods and (1)H and (19)F NMR spectroscopy. Whereas 3- and 4-fluorophenol react with tyrosinase to give products that undergo a rapid polymerization process, 2-fluorophenol is not reactive and actually acts as a competitive inhibitor in the ...
Battaini, G., Monzani, E., Casella, L., Lonardi, E., Tepper, A.W.J.W., Canters, G.W., Bubacco, L.   +6 more
openaire   +5 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Membranes
Lysosomal degradation of tyrosinase, a pivotal enzyme in melanin synthesis, negatively impacts melanogenesis in melanocytes. Nevertheless, the precise molecular mechanisms by which lysosomes target tyrosinase have remained elusive. Here, we identify RING
Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C. J. M. D. S. Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita   +9 more
doaj   +1 more source