Results 1 to 10 of about 12,040 (235)

Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism [PDF]

Molecules, 2022
We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated their inhibition constants. We synthesized 2-(2,6-dimethylhepta-1,5-dien-1-yl)quinazolin-4(3H)-one (Q1) from the natural citral. The concentration, which led to 50%
Yaru Huang, Jiefang Yang, Yunyang Chi, Chun Gong, Haikuan Yang, Fanxin Zeng, Fang Gao, Xiaoju Hua, Zongde Wang   +8 more
doaj   +5 more sources

Tyrosinase Inhibitors: A Perspective

Molecules, 2023
Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have
Mason A. Baber, Cole M. Crist, Noah L. Devolve, James D. Patrone   +3 more
doaj   +3 more sources

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

Molecules, 2018
In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities.
Chang Seok Kim, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hee Jin Jung, Hyung Ryong Moon   +7 more
doaj   +3 more sources

Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids [PDF]

Molecules, 2009
In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were ...
Giovanna Delogu, Lourdes Santana, Carmen Picciau, Gianni Podda, Elias Quezada q, Maria Joao Matos, M. Benedetta Fadda, Benedetta Era, Marcella Corda, Antonella Fais   +9 more
doaj   +5 more sources

Boronic Derivatives of Thiosemicarbazones as Tyrosinase Inhibitors

Pharmaceutics
Background: Tyrosinase is a copper-dependent oxyreductase capable of catalyzing the oxidation of mono- and diphenols. Its activity is crucial in the biosynthetic pathway of melanin, the pigment responsible for the pigmentation of mammalian skin and fur ...
Michał Jewgiński, Msanif Msanif, Honorata Zachary, Mateusz Psurski, Rafał Latajka   +4 more
doaj   +3 more sources

In Vitro and In Vivo Biological Evaluation of Indole-thiazolidine-2,4-dione Derivatives as Tyrosinase Inhibitors

Molecules, 2023
Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with ...
Li Lu, Chunmei Hu, Xiaofeng Min, Zhong Liu, Xuetao Xu, Lishe Gan   +5 more
doaj   +1 more source

Rifampicin is not an inhibitor of tyrosinase

International Journal of Biological Macromolecules, 2022
Rifampicin has been previously described as an inhibitor of tyrosinase (Chai et al., Int. J. Biol. Macromol. 102 (2017) 425-430). However, rifampicin contains a p-diphenol group and compounds with such a moiety have been shown before to reduce tyrosinase-generated o-quinones.
Damian Tarasek, Hubert Wojtasek
openaire   +2 more sources

Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [PDF]

PeerJ, 2018
Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases.
Qi Li, Hongyu Yang, Jun Mo, Yao Chen, Yue Wu, Chen Kang, Yuan Sun, Haopeng Sun   +7 more
doaj   +2 more sources

Synthesis and Biological Activity Evaluation of 2-Cyanopyrrole Derivatives as Potential Tyrosinase Inhibitors

Frontiers in Chemistry, 2022
In order to find potential inhibitors of tyrosinase, two series of pyrrole derivatives A (1–17) and B (1–8) were synthesized and screened for their inhibitory activities on tyrosinase. Most of the 2-cyanopyrrole derivatives exhibited effective inhibitory
Ya-Guang Hu, Zhu-Peng Gao, Ying-Ying Zheng, Chun-Mei Hu, Jing Lin, Xiao-Zheng Wu, Xin Zhang, Yong-Sheng Zhou, Zhuang Xiong, Dao-Yong Zhu   +9 more
doaj   +1 more source

Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters

Molecules, 2023
Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases.
Jianping Li, Xiaofeng Min, Xi Zheng, Shaohua Wang, Xuetao Xu, Jinbao Peng   +5 more
doaj   +1 more source