Results 1 to 10 of about 22,637 (249)

Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism [PDF]

Molecules, 2022
We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated their inhibition constants. We synthesized 2-(2,6-dimethylhepta-1,5-dien-1-yl)quinazolin-4(3H)-one (Q1) from the natural citral. The concentration, which led to 50%
Yaru Huang, Jiefang Yang, Yunyang Chi, Chun Gong, Haikuan Yang, Fanxin Zeng, Fang Gao, Xiaoju Hua, Zongde Wang   +8 more
doaj   +4 more sources

Multifunctional Tyrosinase Inhibitor Peptides with Copper Chelating, UV-Absorption and Antioxidant Activities: Kinetic and Docking Studies [PDF]

Foods, 2021
Nature-derived tyrosinase inhibitors are of great industrial interest. Three monophenolase inhibitor peptides (MIPs) and three diphenolase inhibitor peptides (DIPs) from a previous study were investigated for their in vitro tyrosinase inhibitory effects,
Pei-Gee Yap, Chee-Yuen Gan
doaj   +2 more sources

Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor [PDF]

Molecules, 2021
Tyrosinase is a copper-containing monooxygenase catalyzing the O-hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes.
Hanaa Salah Maamoun, Gamal H. Rabie, Ibrahim Shaker, Bothaina A. Alaidaroos, Ashraf S. A. El-Sayed   +4 more
doaj   +2 more sources

Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor [PDF]

Molecules, 2019
Tyrosinase is an enzyme widely distributed in nature, which has multiple functions, especially in the melanin biosynthesis pathway. Despite the few clinically available tyrosinase inhibitors for whitening, a great demand remains for novel compounds with ...
Huidan Huang, Jianqiu Chen, Jie Ren, Chaofeng Zhang, Fei Ji   +4 more
doaj   +2 more sources

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

Molecules, 2018
In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities.
Chang Seok Kim, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hee Jin Jung, Hyung Ryong Moon   +7 more
doaj   +3 more sources

Boronic Derivatives of Thiosemicarbazones as Tyrosinase Inhibitors [PDF]

Pharmaceutics
Background: Tyrosinase is a copper-dependent oxyreductase capable of catalyzing the oxidation of mono- and diphenols. Its activity is crucial in the biosynthetic pathway of melanin, the pigment responsible for the pigmentation of mammalian skin and fur ...
Michał Jewgiński, Msanif Msanif, Honorata Zachary, Mateusz Psurski, Rafał Latajka   +4 more
doaj   +2 more sources

Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor [PDF]

Frontiers in Chemistry
Liang F.
exaly   +2 more sources

In Vitro and In Vivo Biological Evaluation of Indole-thiazolidine-2,4-dione Derivatives as Tyrosinase Inhibitors

Molecules, 2023
Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with ...
Li Lu, Chunmei Hu, Xiaofeng Min, Zhong Liu, Xuetao Xu, Lishe Gan   +5 more
doaj   +1 more source

Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [PDF]

PeerJ, 2018
Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases.
Qi Li, Hongyu Yang, Jun Mo, Yao Chen, Yue Wu, Chen Kang, Yuan Sun, Haopeng Sun   +7 more
doaj   +2 more sources

Synthesis and Biological Activity Evaluation of 2-Cyanopyrrole Derivatives as Potential Tyrosinase Inhibitors

Frontiers in Chemistry, 2022
In order to find potential inhibitors of tyrosinase, two series of pyrrole derivatives A (1–17) and B (1–8) were synthesized and screened for their inhibitory activities on tyrosinase. Most of the 2-cyanopyrrole derivatives exhibited effective inhibitory
Ya-Guang Hu, Zhu-Peng Gao, Ying-Ying Zheng, Chun-Mei Hu, Jing Lin, Xiao-Zheng Wu, Xin Zhang, Yong-Sheng Zhou, Zhuang Xiong, Dao-Yong Zhu   +9 more
doaj   +1 more source