Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation [PDF]
MoleculesIncreasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis.
Xinhua Ni +4 more
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Tyrosinase Inhibitors: A Perspective [PDF]
Molecules, 2023 Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have
Mason A. Baber +3 more
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Natural Tyrosinase Inhibitors from Lycopodium japonicum [PDF]
MoleculesNatural tyrosinase inhibitors are an important group of compounds with cosmetical and medicinal applications. With the aim of finding new types of natural tyrosinase inhibitors from ornamental and medicinal plants, Lycopodium japonicum was selected and ...
Zeng-Yue Ge +6 more
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Discovery of bis-thiourea derivatives as potent tyrosinase inhibitors: combined experimental and computational study [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryTyrosinase, a key enzyme in melanin synthesis, serves as a primary target for developing depigmenting agents. The search for novel tyrosinase inhibitors is needed due to the adverse effects of current inhibitors.
Sahachai Sabuakham +6 more
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A comprehensive review on tyrosinase inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning.
Samaneh Zolghadri +6 more
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Ultrasound-assisted deep eutectic solvent extraction of tyrosinase inhibitors from lotus seed peel powder [PDF]
Ultrasonics SonochemistryLotus seed peel powder (LSP), a major by-product of lotus seed processing, is rich in bioactive constituents but remains largely underutilized. Conventional aqueous and ethanolic extraction methods for LSP are constrained by low extraction efficiency and
Chengheng Zhang +7 more
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Hydroxyketone Tyrosinase Inhibitors: Mechanism of Action, Applications and Perspectives in Depigmentation and Melanoma Therapy [PDF]
MoleculesTyrosinase is a key enzyme in melanogenesis, playing an important role in skin, hair, and eye pigmentation, as well as in the enzymatic browning of fruits and vegetables.
Barbara Bogdańska +2 more
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Design and computational evaluation of E-stilbene-bearing 1,3,4-oxadiazole derivatives as potential tyrosinase inhibitors using DFT, molecular docking and ADMET studies [PDF]
RSC AdvancesA series of E-stilbene-bearing 1,3,4-oxadiazole derivatives (4a–b and 5a–f) was synthesized via the Mizoroki–Heck reaction and evaluated as inhibitors of tyrosinase, a vital enzyme involved in melanin biosynthesis.
Aasia Javed +2 more
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Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations [PDF]
BMC ChemistryA novel series of 4-nitrophenylpiperazine derivatives (4a–m) was designed and synthesized as potential tyrosinase inhibitors. Comprehensive characterization using 1H-NMR, 13C-NMR, CNH, and IR techniques was performed for all target compounds ...
Mehdi Asadi +8 more
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Anilino-1,4-naphthoquinones as potent mushroom tyrosinase inhibitors: in vitro and in silico studies [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryTyrosinase, a pivotal enzyme in melanin synthesis, is a primary target for the development of depigmenting agents. In this work, in vitro and in silico techniques were employed to identify novel tyrosinase inhibitors from a set of 12 anilino-1,4 ...
Sahachai Sabuakham +6 more
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