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Tyrosinase Inhibitors: A Perspective [PDF]

Molecules, 2023
Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have
Mason A. Baber, Cole M. Crist, Noah L. Devolve, James D. Patrone   +3 more
doaj   +4 more sources

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation [PDF]

Molecules
Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis.
Xinhua Ni, Xinyu Luo, Xiaoying Jiang, Wenchao Chen, Renren Bai   +4 more
doaj   +2 more sources

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +3 more sources

Discovery of bis-thiourea derivatives as potent tyrosinase inhibitors: combined experimental and computational study [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Tyrosinase, a key enzyme in melanin synthesis, serves as a primary target for developing depigmenting agents. The search for novel tyrosinase inhibitors is needed due to the adverse effects of current inhibitors.
Sahachai Sabuakham, Sutita Nasoontorn, Napat Nuramrum, Atit Silsirivanit, Thanyada Rungrotmongkol, Ratchanok Pingaew, Panupong Mahalapbutr   +6 more
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Natural Tyrosinase Inhibitors from Lycopodium japonicum [PDF]

Molecules
Natural tyrosinase inhibitors are an important group of compounds with cosmetical and medicinal applications. With the aim of finding new types of natural tyrosinase inhibitors from ornamental and medicinal plants, Lycopodium japonicum was selected and ...
Zeng-Yue Ge, Ya-Qing Wang, Qi-Bin Yang, Xian-Yun Yan, Lei Wu, Min Zhang, Lin-Fu Liang   +6 more
doaj   +2 more sources

Hydroxyketone Tyrosinase Inhibitors: Mechanism of Action, Applications and Perspectives in Depigmentation and Melanoma Therapy [PDF]

Molecules
Tyrosinase is a key enzyme in melanogenesis, playing an important role in skin, hair, and eye pigmentation, as well as in the enzymatic browning of fruits and vegetables.
Barbara Bogdańska, Dmytro Khylyuk, Dariusz Matosiuk   +2 more
doaj   +2 more sources

Discovery of Novel Tyrosinase Inhibitors From Marine Cyanobacteria [PDF]

Frontiers in Microbiology, 2022
Tyrosinase, an important oxidase involved in the primary immune response in humans, can sometimes become problematic as it can catalyze undesirable oxidation reactions.
Yifan He, Takashi L. Suyama, Hyunwoo Kim, Hyunwoo Kim, Evgenia Glukhov, William H. Gerwick, William H. Gerwick   +6 more
doaj   +2 more sources

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as ...
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam   +2 more
doaj   +2 more sources

Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations [PDF]

BMC Chemistry
A novel series of 4-nitrophenylpiperazine derivatives (4a–m) was designed and synthesized as potential tyrosinase inhibitors. Comprehensive characterization using 1H-NMR, 13C-NMR, CNH, and IR techniques was performed for all target compounds ...
Mehdi Asadi, Fahime Fayazi, Aida Iraji, Reyhaneh Sabourian, Homa Azizian, Mannan Hajimahmoodi, Bagher Larijani, Mohammad Mahdavi, Massoud Amanlou   +8 more
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In Vitro and In Vivo Biological Evaluation of Indole-thiazolidine-2,4-dione Derivatives as Tyrosinase Inhibitors [PDF]

Molecules, 2023
Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with ...
Li Lu, Chunmei Hu, Xiaofeng Min, Zhong Liu, Xuetao Xu, Lishe Gan   +5 more
doaj   +2 more sources