Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors [PDF]
Scientific ReportsTyrosinase is an enzyme crucial for the progression of melanogenesis. Immoderate production of melanin may be the cause of hyperpigmentation and darkening leading to skin diseases.
Zahra Batool +9 more
doaj +2 more sources
Isolation and Biological Evaluation of Human Tyrosinase Inhibitors from the Fruit of <i>Xanthium strumarium</i> L. [PDF]
MoleculesTyrosinase catalyzes the rate-limiting steps of melanin production, posing as an important target for treating skin pigmentation. This study investigates bioactive human tyrosinase inhibitors from Xanthium strumarium L.
Shi G +6 more
europepmc +2 more sources
Peptides and peptidomimetics as inhibitors of tyrosinase [PDF]
, 2023 The publication reviews the results on the tyrosinase inhibition capacity of a short peptide and peptide conjugates with known low molecular weight inhibitors of this enzyme.
Latajka, Rafał +2 more
core +1 more source
Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase
Antioxidants, 2022 Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes ...
Joonhyeok Choi +3 more
doaj +1 more source
tris-Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations. [PDF]
Chem BiodiversNew tris‐Schiff base derivatives of marketed accessible flurbiprofen were synthesised in better yields through multi‐step reactions. Structures of these compounds were deduced through 13C‐NMR and 1H‐NMR spectroscopic methods and finally screened for their in vitro tyrosinase inhibitory potential.
Alam A +9 more
europepmc +2 more sources
Molecules, 2023 Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases.
Jianping Li +5 more
doaj +1 more source
Glycosidic vs. Aglycol Form of Natural Products as Putative Tyrosinase Inhibitors
Biophysica, 2021 Numerous natural products and designed molecules have been evaluated as tyrosinase inhibitors that impede enzymes’ oxidation activity. In the present study, new potent natural inhibitors were retrieved from the ZINC database by the similarity-screening ...
Maria Evgenia Politi +3 more
doaj +1 more source
Naturally-Occurring Tyrosinase Inhibitors Classified by Enzyme Kinetics and Copper Chelation. [PDF]
Int J Mol Sci, 2023 Currently, there are three major assaying methods used to validate in vitro whitening activity from natural products: methods using mushroom tyrosinase, human tyrosinase, and dopachrome tautomerase (or tyrosinase-related protein-2, TRP-2).
Kim HD +6 more
europepmc +2 more sources
Frontiers in Chemistry, 2022 In order to find potential inhibitors of tyrosinase, two series of pyrrole derivatives A (1–17) and B (1–8) were synthesized and screened for their inhibitory activities on tyrosinase. Most of the 2-cyanopyrrole derivatives exhibited effective inhibitory
Ya-Guang Hu +9 more
doaj +1 more source
Discovery of Novel Tyrosinase Inhibitors From Marine Cyanobacteria
Frontiers in Microbiology, 2022 Tyrosinase, an important oxidase involved in the primary immune response in humans, can sometimes become problematic as it can catalyze undesirable oxidation reactions.
Yifan He +6 more
doaj +1 more source