Results 11 to 20 of about 21,627 (244)
A comprehensive review on tyrosinase inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning.
Samaneh Zolghadri +6 more
doaj +4 more sources
Anilino-1,4-naphthoquinones as potent mushroom tyrosinase inhibitors: in vitro and in silico studies [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryTyrosinase, a pivotal enzyme in melanin synthesis, is a primary target for the development of depigmenting agents. In this work, in vitro and in silico techniques were employed to identify novel tyrosinase inhibitors from a set of 12 anilino-1,4 ...
Sahachai Sabuakham +6 more
doaj +2 more sources
Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids [PDF]
Molecules, 2009 In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-
FAIS, ANTONELLA +9 more
openaire +7 more sources
Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors [PDF]
Scientific ReportsTyrosinase is an enzyme crucial for the progression of melanogenesis. Immoderate production of melanin may be the cause of hyperpigmentation and darkening leading to skin diseases.
Zahra Batool +9 more
doaj +2 more sources
Heterocyclic Compounds as Synthetic Tyrosinase Inhibitors: Recent Advances [PDF]
International Journal of Molecular Sciences, 2023 Serena Vittorio +2 more
exaly +2 more sources
Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase
Antioxidants, 2022 Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes ...
Joonhyeok Choi +3 more
doaj +1 more source
Phlorotannins Derived From the Brown Alga as Tyrosinase Inhibitors
Natural Product Communications, 2021 Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase
Hideyuki Kurihara, Kazuki Kujira
doaj +1 more source
Molecules, 2023 Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases.
Jianping Li +5 more
doaj +1 more source
Biomolecules, 2020 Tyrosinase plays a key role in the production of melanin. A variety of industrial fields have shown interest in the development of tyrosinase inhibitors from plants.
Jang Hoon Kim +2 more
doaj +1 more source
Glycosidic vs. Aglycol Form of Natural Products as Putative Tyrosinase Inhibitors
Biophysica, 2021 Numerous natural products and designed molecules have been evaluated as tyrosinase inhibitors that impede enzymes’ oxidation activity. In the present study, new potent natural inhibitors were retrieved from the ZINC database by the similarity-screening ...
Maria Evgenia Politi +3 more
doaj +1 more source