Results 1 to 10 of about 3,160,114 (308)

Design of Docking Mechanism Measurement and Control System for Space Docking Simulation Test-bed [PDF]

Jisuanji gongcheng, 2017
In order to implement the rendezvous and docking of two space aircrafts,the simulation debugging of the rendezvous and docking process must be done.So this paper builds a space docking hardware-in-the-loop simulation test-bed which overcomes the limit of
LI Shuangquan,DU Yajuan,LIU Lingfeng
doaj   +2 more sources

Novel Isosteviol-Based FXa Inhibitors: Molecular Modeling, In Silico Design and Docking Simulation [PDF]

Molecules, 2023
Direct oral anticoagulants are an important and relatively new class of synthetic anticoagulant drugs commonly used for the pharmacotherapy of thromboembolic disorders.
Marcin Gackowski, Burhanuddin Madriwala, Renata Studzińska, Marcin Koba   +3 more
doaj   +2 more sources

Quantitative Analysis and Molecular Docking Simulation of Flavonols from Eruca sativa Mill. and Their Effect on Skin Barrier Function [PDF]

Current Issues in Molecular Biology
Eruca sativa is a commonly used edible plant in Italian cuisine. E. sativa 70% ethanol extract (ES) was fractionated with five organic solvents, including n-hexane (EHex), chloroform (ECHCl3), ethyl acetate (EEA), n-butyl alcohol (EBuOH), and water (EDW).
Jihye Park, Wonchul Choi, Jayoung Kim, Hye Won Kim, Jee-Young Lee, Jongsung Lee, Bora Kim   +6 more
doaj   +2 more sources

Modifying Surface Charges of a Thermophilic Laccase Toward Improving Activity and Stability in Ionic Liquid

Frontiers in Bioengineering and Biotechnology, 2022
The multicopper oxidase enzyme laccase holds great potential to be used for biological lignin valorization alongside a biocompatible ionic liquid (IL).
Joseph C. Stevens, Jian Shi
doaj   +1 more source

Comparative in vitro/theoretical studies on the anti-angiogenic activity of date pollen hydro-alcoholic extract: Highlighting the important roles of its hot polyphenols [PDF]

BioImpacts, 2018
Introduction: Date palm pollen (DPP) is the male reproductive soft powder from date flowers widely used as the valuable dietary supplement to fortify the size of testis and ovarian to increase the power of sex.
Hassan Rasouli, Amir Hossein Norooznezhad, Tahereh Rashidi, Zohreh Hoseinkhani, Azadeh Mahnam, Mitra Tarlan, Narges Moasefi, Ali Mostafaei, Kamran Mansouri   +8 more
doaj   +1 more source

Development and Assessment of 1,5–Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK–2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation

Molecules, 2023
New 1,5-diarylpyrazole oxime hybrid derivatives (scaffolds A and B) were designed, synthesized, and then their purity was verified using a variety of spectroscopic methods.
Kamal S. Abdelrahman, Heba A. Hassan, Salah A. Abdel-Aziz, Adel A. Marzouk, Raef Shams, Keima Osawa, Mohamed Abdel-Aziz, Hiroyuki Konno   +7 more
doaj   +1 more source

Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris

Chemistry, 2021
The 70% ethanol extract of Artemisia campestris was screened to find PPARγ ligands using the PPARγ ligand-responsive chimera luciferase reporter system. Capillartemisin B was identified as a PPARγ ligand that stimulated lipid accumulation in 3T3-L1 cells.
Tokio Hasegawa, Mayo Osaka, Yusaku Miyamae, Katsutoshi Nishino, Hiroko Isoda, Kiyokazu Kawada, Mohamed Neffati, Kazuhiro Irie, Masaya Nagao   +8 more
doaj   +1 more source

Effects of In Vitro Digestion of Polyphenols from Coffee on Binding Parameters to Human Topoisomerase II α

Molecules, 2023
Type II topoisomerase (TOPII) is an enzyme that influences the topology of DNA. DNA breaks generated by TOPII may result in mutagenic or cytotoxic changes in cancer cells.
Joanna Grzelczyk, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Joanna Oracz, Grażyna Budryn   +4 more
doaj   +1 more source

Molecular Docking, Drug-Likeness Analysis, In Silico Pharmacokinetics, and Toxicity Studies of p-Nitrophenyl Hydrazones as Anti-inflammatory Compounds against COX-2, 5-LOX, and H+/K+ ATPase

Pharmaceutical Fronts, 2022
Nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs are traditional medicines for the treatment of inflammation, yet associated with serious side effects.
Sodeeq Babalola, Nosakhare Igie, Isaiah Odeyemi   +2 more
doaj   +1 more source

In Silico Multi-Target Approach Revealed Potential Lead Compounds as Scaffold for the Synthesis of Chemical Analogues Targeting SARS-CoV-2

Biology, 2022
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), an infectious disease that spreads rapidly in humans. In March 2020, the World Health Organization (WHO) declared a COVID-19 pandemic.
Alfonso Trezza, Claudia Mugnaini, Federico Corelli, Annalisa Santucci, Ottavia Spiga   +4 more
doaj   +1 more source