Results 31 to 40 of about 126,162 (305)
Alchemy, 2023 Diabetes Melitus (DM) Tipe 2 merupakan penyakit dengan gejala hiperglikemia dengan jumlah kasus yang meningkat setiap harinya pada populasi dunia. Enzim yang berperan terkait DM Tipe 2 yaitu α-amilase dan α-glukosidase yang bertindak dalam menghidrolisis
Syafrizayanti Syafrizayanti +3 more
doaj +1 more source
Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase [PDF]
, 2017 The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold.
Accordino, Sebastian Roberto +5 more
core +1 more source
Structural requirements for ligands of the δ-opioid receptor [PDF]
Journal of the Serbian Chemical Society, 2009 The δ-opioid receptor is sensitive to ligand geometry. In order to assist the synthesis of new δ-selective opioid ligands, the structure elements of δ-selective opioid ligands necessary for their effective binding were investigated. The automated docking
Mićović Vuk I. +2 more
doaj +3 more sources
Modeling, Docking, and Simulation of the Major Facilitator Superfamily [PDF]
Biophysical Journal, 2006 X-ray structures are known for three members of the Major Facilitator Superfamily (MFS) of membrane transporter proteins, thus enabling the use of homology modeling to extrapolate to other MFS members. However, before employing such models for, e.g., mutational or docking studies, it is essential to develop a measure of their quality.
Holyoake, J +3 more
openaire +3 more sources
Learning visual docking for non-holonomic autonomous vehicles [PDF]
, 2008 This paper presents a new method of learning visual docking skills for non-holonomic vehicles by direct interaction with the environment. The method is based on a reinforcement algorithm, which speeds up Q-learning by applying memorybased sweeping and ...
Duckett, Tom, Martinez-Marin, Tomas
core +1 more source
Modeling the ligand specific m- and d-opioid receptor conformations [PDF]
Journal of the Serbian Chemical Society, 2011 An automated docking procedure was applied to study the binding of a series of m- and d-selective ligands to ligand-specific m- and d-opioid receptor models.
MILAN SENĆANSKI +3 more
doaj
Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors
Pharmaceuticals, 2023 Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer’s disease (AD).
Ashraf K. El-Damasy +6 more
doaj +1 more source
Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]
, 2011 The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong +7 more
core +2 more sources
Molecules1-deoxynojirimycin (DNJ) is a well-known α-glucosidase inhibitor. A series of phenyltriazole-deoxynojirimycin hybrids containing C4 and C6 (4 and 6 methylenes, respectively) linkers were synthesized.
Lin Wang +6 more
doaj +1 more source
Frontiers in Chemistry, 2019 Clarified the binding mechanism of drugs with plasma proteins could provide fresh insights into the drug development. Caffeoylquinic acids (CQAs) are a kind of phenolic acid compounds which has extensive biological effects.
Qishu Jiao +5 more
doaj +1 more source