Results 41 to 50 of about 677,076 (187)

Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific Inhibitors from Puerariae lobatae Radix

Molecules, 2018
Enzyme inhibitors from natural products are becoming an attractive target for drug discovery and development; however, separating enzyme inhibitors from natural-product extracts is highly complex.
Haichun Liu, Yitian Zhu, Ting Wang, Jin Qi, Xuming Liu   +4 more
doaj   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Tyrosinase inhibitors as potential antibacterial agents

, 2019
Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses ...
Nazir, Yasir, Barnard, Ross T., Yuan, Ye, Thomas Blaskovich, Mark A., Ziora, Zyta M., Jin, Wanli, Fercher, Christian, Cooper, Matthew A.   +7 more
core   +1 more source

Synthesis and Studies of the Inhibitory Effect of Hydroxylated Phenylpropanoids and Biphenols Derivatives on Tyrosinase and Laccase Enzymes

Molecules, 2020
The impaired activity of tyrosinase and laccase can provoke serious concerns in the life cycles of mammals, insects and microorganisms. Investigation of inhibitors of these two enzymes may lead to the discovery of whitening agents, medicinal products ...
Maria Antonietta Dettori, Davide Fabbri, Alessandro Dessì, Roberto Dallocchio, Paola Carta, Claudia Honisch, Paolo Ruzza, Donatella Farina, Rossana Migheli, Pier Andrea Serra, Roberto A. Pantaleoni, Xenia Fois, Gaia Rocchitta, Giovanna Delogu   +13 more
doaj   +1 more source

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Christopher Cheng, Elena Sviderskaya, Sviderskaya, EV, Lam, RY, Zhi-Xiu Lin, Lin, ZX, Rosanna Lam, Cheng, CH   +7 more
core   +1 more source

Using deep learning to predict tyrosinase inhibitors for treating hyperpigmentation disorders [PDF]

PeerJ
Background In recent years, skin health has garnered widespread attention, with hyperpigmentation disorders caused by excessive melanin deposition emerging as a particularly prominent concern.
RenHui Wu, MengMeng Yang, TianChi Wu, RongZhen Li, Yuhui Wang, XiaoTian Xu   +5 more
doaj   +2 more sources

Linking Polyelectrolyte Modification and Enzyme‐Catalyzed Phenolic Acid Functionalization of Cellulose Fiber for Functional Foams

Advanced Materials Technologies, EarlyView.
Cellulose fibers functionalized using cationic poly(Dimethyldiallylammonium chloride) (polyDADMAC) and laccase‐mediated ferulic acid system are processed into foams using different surfactants (Anionic, cationic, and non‐ionic). Fiber–surfactant interactions influence foam stabilization and porous structure formation during convective drying, producing
Abirami Senthil, Sara Wallstén, Paul Christakopoulos, Ulrika Rova, Io Antonopoulou   +4 more
wiley   +1 more source

Proanthocyanidins Extracted from Rhododendron pulchrum Leaves as Source of Tyrosinase Inhibitors: Structure, Activity, and Mechanism. [PDF]

PLoS ONE, 2015
The objective of this study was to assess the structure, anti-tyrosinase activity, and mechanism of proanthocyanidins extracted from Rhododendron pulchrum leaves.
Wei-Ming Chai, Rui Wang, Man-Kun Wei, Zheng-Rong Zou, Rong-Gen Deng, Wei-Sheng Liu, Yi-Yuan Peng   +6 more
doaj   +1 more source

New Class of Tyrosinase Inhibitors, Rotenoids, from Amorpha fruticosa

, 2023
A series of rotenoids including a new one from the seeds of Amorpha fruticosa were found to have significant potential as tyrosinase inhibitors. All of the isolated rotenoids (1–6) displayed inhibitory activity against tyrosinase, both as a monophenolase
Ki Hun Park (511972), Jeong Yoon Kim, Si Won Moon (16872197), Ki Hun Park, Jeong Yoon Kim (2853743), Se Young Im, Se Young Im (16872200), Seung Hwan Lee (467661), Gihwan Lee, Gihwan Lee (10679190), Seung Hwan Lee, Si Won Moon   +11 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source