Results 41 to 50 of about 21,627 (244)

Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]

, 2014
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC, Bowcock, AM, Carvajal, RD, Flaherty, KT, Gershenwald, JE, Gutkind, JS, Luke, JJ, McKenna, KC, Patel, PM, Sato, T, Selig, S, Sossman, JA, Streicher, HZ, Sznol, M, Thurin, M, Triozzi, PL, Van Meir, EG, Welch, J   +17 more
core   +1 more source

Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum laricifolium Juss

Molecules, 2017
Tyrosinase inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. Peru is a diverse country with a wide variety of plants that may contain excellent anti-tyrosinase inhibitors. In the present study, the tyrosinase
Yanymee Nimesia Guillen Quispe, Seung Hwan Hwang, Zhiqiang Wang, Soon Sung Lim   +3 more
doaj   +1 more source

Anorectal Melanoma [PDF]

, 2018
Anorectal melanoma (AM) is a rare malignancy, characterized by aggressive behavior and a poor prognosis. AM is more frequent in female patients aged over 50 years.
Dario Didona, Giovanni Paolino, Giulia Macrì, Santo Raffaele Mercuri., Stefano Calvieri   +4 more
core   +1 more source

Catalysis-based specific detection and inhibition of tyrosinase and their application

Journal of Pharmaceutical Analysis, 2020
Tyrosinase is an important enzyme in controlling the formation of melanin in melanosome, and plays a key role in the pigmentation of hair and skin. The abnormal expression or activation of tyrosinase is associated with several diseases such as albinism ...
Yunwei Qu, Qing Zhan, Shubo Du, Yang Ding, Bin Fang, Wei Du, Qiong Wu, Haidong Yu, Lin Li, Wei Huang   +9 more
doaj   +1 more source

A Competitive Inhibitor of Tyrosinase [PDF]

Australian Journal of Biological Sciences, 1951
The kinetics of the activation of catechol by tyrosinase prepared from the potato and the mushroom, and of its inhibition by sodium m-hydroxybenzoate, have been studied. The enzyme-substrate dissociation constants differed markedly between the two enzyme sources (K.
openaire   +2 more sources

Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific Inhibitors from Puerariae lobatae Radix

Molecules, 2018
Enzyme inhibitors from natural products are becoming an attractive target for drug discovery and development; however, separating enzyme inhibitors from natural-product extracts is highly complex.
Haichun Liu, Yitian Zhu, Ting Wang, Jin Qi, Xuming Liu   +4 more
doaj   +1 more source

Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp maritima: from traditional remedies to prospective products [PDF]

, 2018
This work explored the biotechnological potential of the medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source of health promoting commodities.
A Akrout, A Alam, A Atia, A Buhmann, A Djeridane, A Lopes, AA Jahid, AP Rauter, AS Ribeiro, B Boulanouar, B Saad, CG Pereira, CG Pereira, D Paepe De, DA Viegas, DR Nogueira, F Shahidi, H Akkari, H Riedel, H Sebai, I Dib, I Jallali, JF Sanz, JG Gruenwald, JMJ Vasconcelos, KM Valant-Vetschera, L Barreira, L Custódio, M Karamać, M Saoudi, M Sefi, MJ Rodrigues, MJ Rodrigues, MJ Rodrigues, MP Kähkönen, MTH Khan, N Balasundram, P Pohl, R Ksouri, RW Pero, S Kumar, S Saeidnia, SK Panigrahy, T Oki, T-S Chang, V Sindhi, W Megdiche-Ksouri, YI Kwon, Z Ghlissi   +48 more
core   +2 more sources

Thiopurine Drugs Repositioned as Tyrosinase Inhibitors [PDF]

International Journal of Molecular Sciences, 2017
Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors.
Choi, Joonhyuck, Lee, You-Mie, Jee, Jun-Goo   +2 more
openaire   +2 more sources

Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]

, 2018
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski, Anna Brożyna, Anna Markiewicz, Bożena Romanowska-Dixon, Ewa Podgórska, Krystyna Urbańska, Martyna Elas, Martyna Śniegocka, Małgorzata Szczygieł, Michał Żmijewski, Mirosława Cichorek, Przemysław Płonka   +11 more
core   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source