Results 51 to 60 of about 21,627 (244)

Synthesis and Studies of the Inhibitory Effect of Hydroxylated Phenylpropanoids and Biphenols Derivatives on Tyrosinase and Laccase Enzymes

Molecules, 2020
The impaired activity of tyrosinase and laccase can provoke serious concerns in the life cycles of mammals, insects and microorganisms. Investigation of inhibitors of these two enzymes may lead to the discovery of whitening agents, medicinal products ...
Maria Antonietta Dettori, Davide Fabbri, Alessandro Dessì, Roberto Dallocchio, Paola Carta, Claudia Honisch, Paolo Ruzza, Donatella Farina, Rossana Migheli, Pier Andrea Serra, Roberto A. Pantaleoni, Xenia Fois, Gaia Rocchitta, Giovanna Delogu   +13 more
doaj   +1 more source

A tyrosinase inhibitor from Aspergillus niger [PDF]

Journal of Food Science and Technology, 2014
Tyrosinase, in the presence of oxygen, is the main culprit in post harvest browning of food products, resulting in the drop in its commercial value. In an effort to seek natural tyrosinase inhibitors for food applications, a screening programme was undertaken. Of the 26 fungal cultures isolated from soil samples of Agumbe forest, India, one isolate S16,
K Y, Vasantha, C S, Murugesh, A P, Sattur   +2 more
openaire   +2 more sources

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]

, 2018
Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria, Bottero, Lisabianca, Carè, Alessandra, Felicetti, Federica, Gulino, Alessandro, Mattia, Gianfranco, Petrini, Marina, Pontecorvi, Giada, Puglisi, Rossella   +8 more
core   +1 more source

Proanthocyanidins Extracted from Rhododendron pulchrum Leaves as Source of Tyrosinase Inhibitors: Structure, Activity, and Mechanism. [PDF]

PLoS ONE, 2015
The objective of this study was to assess the structure, anti-tyrosinase activity, and mechanism of proanthocyanidins extracted from Rhododendron pulchrum leaves.
Wei-Ming Chai, Rui Wang, Man-Kun Wei, Zheng-Rong Zou, Rong-Gen Deng, Wei-Sheng Liu, Yi-Yuan Peng   +6 more
doaj   +1 more source

Novel Anti-Melanogenic Compounds, (Z)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights

Molecules, 2021
To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve (Z)-5-(substituted benzylidene)-4-thioxothiazolidin-2-
Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, In-Soo Yoon, Hwayoung Yun, Min-Soo Kim, Jin-Wook Yoo, Yunjin Jung, Pusoon Chun, Hyung Ryong Moon   +15 more
doaj   +1 more source

Using deep learning to predict tyrosinase inhibitors for treating hyperpigmentation disorders [PDF]

PeerJ
Background In recent years, skin health has garnered widespread attention, with hyperpigmentation disorders caused by excessive melanin deposition emerging as a particularly prominent concern.
RenHui Wu, MengMeng Yang, TianChi Wu, RongZhen Li, Yuhui Wang, XiaoTian Xu   +5 more
doaj   +2 more sources

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Antityrosinase activity of Euphorbia characias extracts [PDF]

PeerJ, 2015
Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents.
Francesca Pintus, Delia Spanò, Angela Corona, Rosaria Medda   +3 more
doaj   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Natural peptides and proteins: potent tyrosinase inhibitors [PDF]

Research Journal of Pharmacognosy, 2017
Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals.
R. Hariri*, M. Saeedi, T. Akbarzadeh
doaj