Results 71 to 80 of about 677,076 (187)

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

New Inhibitors of Laccase and Tyrosinase by Examination of Cross-Inhibition between Copper-Containing Enzymes

, 2021
Coppers play crucial roles in the maintenance homeostasis in living species. Approximately 20 enzyme families of eukaryotes and prokaryotes are known to utilize copper atoms for catalytic activities.
Trilok Neupane, Fangchen Chong, Dinesh Chaudhary, Joonhyeok Choi, Jun-Goo Jee   +4 more
core   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Theoretical studies of arbutin, glutathione, and sea cucumber extracts as inhibitors of tyrosinase

Scientific Reports
Tyrosinase is a crucial enzyme targeted for the development of various skin-whitening agents due to its role in regulating key steps in melanin production.
Zheng Zheng, Shizhuo Zhang, Tao Jiang, Wenlang Liu, Zifan Xu, Xinyi Shen, Tiantian Sun   +6 more
doaj   +1 more source

Advances in the Tyrosinase Inhibitors from Plant Source

, 2019
Tyrosinase is a multifunctional copper-containing oxidase which catalyses the oxidation of tyrosine to produce melanin. The alteration in melanin biosynthesis occurs in many diseases. The pigment has a protecting role against skin photo-carcinogenesis,
Vincenzo Sicari, Jianbo Xiao, Monica R. Loizzo, Francesca Aiello, Marco Bonesi, Rosa Tundis   +5 more
core   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source

Flavones as tyrosinase inhibitors: kinetic studies in vitro and in silico. [PDF]

, 2019
Collaboration between DMU-Leicester School of Pharmacy (UK), Hacettepe University, Faculty of Pharmacy, Ankara (Turkey) and Karadeniz Technical University, Faculty of Pharmacy, Trabzon (Turkey).Introduction – Tyrosinase is a multifunctional copper ...
Ruparelia, K. C., Ozel, Arzu, Sohretoglu, Didem, Arroo, R. R. J., Barut, Burak, Sari, Suat, Randolph R.J. Arroo, Suat Sari, Didem Şöhretoğlu, Burak Barut, Arzu Özel, Arroo, Randolph R. J., Ruparelia, Ketan C., Ketan C. Ruparelia   +13 more
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

N-Benzylbenzamides: A new class of potent tyrosinase inhibitors

, 2006
A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity.
J S Roh, S J Cho, K D Park, W S Sun, S H Kim   +4 more
core   +1 more source