Results 91 to 100 of about 21,627 (244)

Peptide and peptidomimetic tyrosinase inhibitors

Melanin, which is produced by melanocytes and spread over keratinocytes, is responsible for human skin browning. There are several processes involved in melanogenesis, mostly prompted by enzymatic activities. Tyrosinase (TYR), a copper containing metalloenzyme, is considered the main actor in melanin production, as it catalyzes two crucial steps that ...
Errante, Fosca, Sforzi, Lucrezia, Supuran, Claudiu T., Papini, Anna Maria, Rovero, Paolo   +4 more
openaire   +3 more sources

In silico assessment of the inhibitory effect of four flavonoids (Chrysin, Naringin, Quercetin, Kaempferol) on tyrosinase activity using the MD simulation approach

BioTechnologia, 2020
Tyrosinase is a tetrameric enzyme that plays an important role in pigment production. Overproduction of melanin, which may lead to several skin disorders, is a result of tyrosinase activity.
ALIREZA FARASAT, MOHAMAD GHORBANI, NEMATOLLAH GHEIB, HANIFEH SHARIATIFAR   +3 more
doaj   +1 more source

Valorization of fruit pits from Prunus laurocerasus and Prunus cerasifera as agro‐food byproducts: Bioactive properties and safety assessment for potential food additive applications

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Food additives are widely used to extend the shelf life of foods and maintain their quality. In this study, the potential of Prunus laurocerasus and Prunus cerasifera fruit pits (endocarp and seed) as food additives was investigated in terms of cytotoxicity, antigenotoxicity, antioxidant activity, enzymatic anti‐browning, and urease
Zühal Bayrakçeken Güven, Mehmet Karadayı, Mustafa Abdullah Yilmaz, Osman Tugay, Oguz Cakir   +4 more
wiley   +1 more source

Dialkylphosphorylhydrazones as potent tyrosinase inhibitors

Journal of the Brazilian Chemical Society, 2012
Nineteen dialkylphosphorylhydrazones with different substituents at the aromatic ring were evaluated as potential tyrosinase inhibitors, which could then be used as efficient agents in the control of pigmentation disorders. The inhibition activity was measured by a modified Patil and Zucker UV-Vis method.
Caixeiro, Janaína M. R., Gonçalves, Vinicius T., Oliveira, Márcia C. C. de, Sant'Anna, Carlos M. R., Rumjanek, Victor M., DaCosta, João B. N.   +5 more
openaire   +3 more sources

Insights on cytotoxic cells of the colonial ascidian Botryllus schlosseri [PDF]

, 2015
Morula cells (MCs) represent the most abundant circulating hemocyte of the compound ascidian Botryllus schlosseri. They are cytotoxic cells involved in the rejection reaction between contacting, genetically incompatible colonies.
Ballarin, Loriano, Cima, Francesca, Franchi, Nicola   +2 more
core  

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]

, 2008
Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE, Billett, EE, Caneda-Ferrón, B, Costa, T, De, Girolamo, Layfield, R   +5 more
core   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

DOCKING OF TYROSINASE CICLOARTANE INHIBITORS

Vitae, 2009
Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity relationship has been studied on similar compounds ...
Pablo A. GUTIÉRREZ, Benjamín A. ROJANO
openaire   +2 more sources

Tyrosinase inhibitors and insecticidal materials produced by Burkholderia cepacia using squid pen as the sole carbon and nitrogen source [PDF]

[[abstract]]Reports of tyrosinase inhibitors from microorganisms are rare. A tyrosinase inhibitor- and insecticidal materials-producing bacterium, strain TKU026, was isolated from Taiwanese soil and identified as Burkholderia cepacia.
A Venditti, AH Rodríguez, Anh Dzung Nguyen, C Imada, C Liang, Chia-Hao Hsu, CK Hsu, E Neeley, GC Yen, JRW Govan, K Maeda, K Shimizu, KU Schallreuter, L Kolbe, M Miyazawa, San-Lang Wang, SL Wang, SL Wang, T Nakashima, T Sabudak, TS Chang, WR Hyung, X Li, Y Kang, YJ Kim, Yung-Wei Chen, ZZ Pan   +26 more
core   +1 more source

Inhibition-based first-generation electrochemical biosensors: theoretical aspects and application to 2,4-dichlorophenoxy acetic acid detection [PDF]

, 2016
In this work, several theoretical aspects involved in the first-generation inhibition-based electrochemical biosensor measurements have been discussed. In particular, we have developed a theoretical-methodological approach for the characterization of the
Antiochia, Riccarda, Bollella, Paolo, Favero, Gabriele, Fusco, Giovanni, Mazzei, Franco, Sanzo', Gabriella, Tortolini, Cristina   +6 more
core   +1 more source