Results 31 to 40 of about 706,934 (223)

Tyrosinase-Catalyzed Peptide Macrocyclization for mRNA Display

, 2023
mRNA display of macrocyclic peptides has proven itself to be a powerful technique to discover high-affinity ligands for a protein target. However, only a limited number of cyclization chemistries are known to be compatible with mRNA display.
Albert A. Bowers, Rodney Park, Albert A. Bowers (1635184), Matthew C. Fleming (12511044), Rodney Park (12034850), Matthew M. Bowler (11973582), Konstantin I. Popov (6519812), Matthew M. Bowler, Konstantin I. Popov, Matthew C. Fleming   +9 more
core   +1 more source

Rational design of an N-terminal cysteine-containing tetrapeptide that inhibits tyrosinase and evaluation of its mechanism of action

Current Research in Food Science, 2023
There has been a resurgence of interest in bioactive peptides as therapeutic agents. This is particularly interesting for tyrosinase, which can be inhibited by thiol-containing peptides.
Anupong Joompang, Preeyanan Anwised, Sompong Klaynongsruang, Lapatrada Taemaitree, Anuwat Wanthong, Kiattawee Choowongkomon, Sakda Daduang, Somporn Katekaew, Nisachon Jangpromma   +8 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Novel tyrosinase inhibitory peptide with free radical scavenging ability

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a key enzyme involved in melanin synthesis. Therefore, various tyrosinase inhibitors have been screened by researchers in recent years. In the present study, we discovered a novel tyrosinase inhibitor, a peptide ECGYF (named EF-5), with ...
Zhiwei Shen, Yujiao Wang, Zhen Guo, Tingyuan Tan, Yi Zhang   +4 more
doaj   +1 more source

Potency of Jack Fruit Leaves as Tyrosinase Inhibitor [PDF]

, 2016
The aim of this study is to screen whitening agent potency from Jack fruit leaves compared between 96% ethanol extract from young Jack fruit leaves (green to white) and mature Jack fruit leaves (dark green).
Gunawan, Hendra, P. Priosoeryanto, Bambang, Wientarsih, Ietje, Rayendra, Raendi   +3 more
core   +1 more source

Tyrosinase Inhibitor and Antioxidant Activity of Seaweed Powder from Fresh and Dried Sargassum plagyophyllum [PDF]

, 2017
Sargassum plagyophyllum from Sargassaceae family contains various bioactive compounds, namelyphlorotannin which is reported as an antioxidant and tyrosinase inhibitor.
Ayun Erwina Arifianti, Anwar, Effionora, Arifianti, Ayun Erwina, Nurjanah, Nurjanah, Effionora Anwar, Nurjanah Nurjanah   +5 more
core   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis

, 2009
The alkylhydroquinone 10'(Z)-heptadecenylhydroquinone [HQ17( 1)], isolated from the sap of the lacquer tree Rhus succedanea, was found to inhibit the activity of tyrosinase and to suppress melanin production in animal cells.
Chen, Yun-Ru; Chiou, Robin Y.-Y.; Lin, Ting-Yu; Huang, Cheng-Po; Tang, Wei-Chien; Chen, Shui-Tein; Lin, Shwu-Bin, 陳韻如;邱義源;黃政博;林淑萍   +1 more
core   +1 more source

Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

Journal of Chemistry, 2013
In continuation with our research program, in search of potent enzyme tyrosinase inhibitor, a series of synthesized 2,5-disubstituted 1,3,4-oxadiazoles have been evaluated for enzyme tyrosinase inhibitory activity.
Ramesh L. Sawant, Prashant D. Lanke, Jyoti B. Wadekar   +2 more
doaj   +1 more source

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives

Pharmaceuticals, 2023
Heterocyclic nuclei have shown a wide variety of biological activities, highlighting their importance in drug discovery. Derivatives of 2,4-subsituted thiazolidine have a structural similarity with the substrates of tyrosinase enzymes. Hence, they can be
Muhammad Kazim Zargaham, Madiha Ahmed, Nosheen Akhtar, Zaman Ashraf, Mostafa A. Abdel-Maksoud, Mohammed Aufy, Humaira Nadeem   +6 more
doaj   +1 more source