Results 31 to 40 of about 12,040 (235)

A New Fluorinated Tyrosinase Inhibitor from a Chemically Engineered Essential Oil [PDF]

, 2016
The generation of fluorinated essential oils as a source of bioactive compounds is described. Most of the components of the natural mixtures were altered, leading to the discovery of a new fluorinated tyrosinase ...
García, Paula, Furlan, Ricardo Luis Eugenio, Ramallo, Ivana Ayelen, Paula García (2743225), Salazar, Mario Oscar, Ricardo L. E. Furlan (2015701), I. Ayelen Ramallo (2224210), Mario O. Salazar (2224213)   +7 more
core   +1 more source

Antamanide Analogs as Potential Inhibitors of Tyrosinase

International Journal of Molecular Sciences, 2022
The tyrosinase enzyme, which catalyzes the hydroxylation of monophenols and the oxidation of o-diphenols, is typically involved in the synthesis of the dark product melanin starting from the amino acid tyrosine. Contributing to the browning of plant and fruit tissues and to the hyperpigmentation of the skin, leading to melasma or age spots, the ...
Honisch C, Gazziero M, Dallocchio R, Dessi A, Fabbri D, Dettori MA, Delogu G, Ruzza P   +7 more
openaire   +4 more sources

Rational design of an N-terminal cysteine-containing tetrapeptide that inhibits tyrosinase and evaluation of its mechanism of action

Current Research in Food Science, 2023
There has been a resurgence of interest in bioactive peptides as therapeutic agents. This is particularly interesting for tyrosinase, which can be inhibited by thiol-containing peptides.
Anupong Joompang, Preeyanan Anwised, Sompong Klaynongsruang, Lapatrada Taemaitree, Anuwat Wanthong, Kiattawee Choowongkomon, Sakda Daduang, Somporn Katekaew, Nisachon Jangpromma   +8 more
doaj   +1 more source

Rhododendrol glycosides as stereospecific tyrosinase inhibitors [PDF]

Bioorganic & Medicinal Chemistry, 2015
Rhododendrol derivatives 3-12 have been synthesized in six steps, including aldol condensation and/or trichloroacetimidate glycosylation as the key reactions. Each derivative showed effective inhibition of tyrosinase-catalyzed oxidation processes. In particular, a series of synthetic derivatives having an R-stereogenic center at C-2 proved to be more ...
Takehiro, Iwadate, Ken-ichi, Nihei
openaire   +2 more sources

Novel tyrosinase inhibitory peptide with free radical scavenging ability

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a key enzyme involved in melanin synthesis. Therefore, various tyrosinase inhibitors have been screened by researchers in recent years. In the present study, we discovered a novel tyrosinase inhibitor, a peptide ECGYF (named EF-5), with ...
Zhiwei Shen, Yujiao Wang, Zhen Guo, Tingyuan Tan, Yi Zhang   +4 more
doaj   +1 more source

Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet

Journal of Chemistry, 2018
Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in ...
Wen-Ying Huang, Hui-Ju Chen, Chia-Ching Lin, Chin-Shuh Chen, Yung-Sheng Lin   +4 more
doaj   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Synthesis and Tyrosinase Inhibitory Activity of (E)-5-Benzyl-7- (3-Bromobenzylidene)-3-(3-Bromophenyl)-2-Phenyl-3,3a, 4,5,6,7-Hexahydro-2H-Pyrazolo[4,3-c]Pyridine

Jurnal Kimia Sains dan Aplikasi, 2022
The tyrosinase enzyme plays an essential role in the pigmentation of human skin, fruits, and vegetables. It has been tied with several human skin diseases and post-harvest problems.
Nelly Oscifiani, Noval Herfindo, Rahayu Rahayu, Neni Frimayanti, Adel Zamri   +4 more
doaj   +1 more source

New saccharin derivatives as tyrosinase inhibitors

Bioorganic & Medicinal Chemistry, 2012
A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a-y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme with 6.85% yield was achieved by using a Sepharose 4B-l-tyrosine-p-amino benzoic acid affinity column.
Gençer, Nahit, Demir, Dudu, Sönmez, Fatih, Küçükislamoğlu, Mustafa   +3 more
openaire   +4 more sources

Optimal Culture Conditions on the Tyrosinase Inhibitor Production by Actinomycetes F-97

, 2007
A Actinomycetes F-97 producing tyrosinase inhibitor was isolated from soil samples. The optimum culture condition for tyrosinase inhibitor production was investigated and the results were as follows.
Jin-O Kim, Byung-Ho Bang, Dong-Heui Yi, Moon-Soo Rhee, J O Kim, D H Yi, B H Bang, Moon Soo Rhee   +7 more
core   +1 more source