Results 11 to 20 of about 568,389 (237)
Screening Marker Components Of Tyrosinase Inhibitor From Xylocarpus Granatum Stem [PDF]
Jurnal Kimia Valensi, 2012 The aim of our research was to screen the marker components of tyrosinase inhibitor from Xylocarpus granatum stem collected from Pulau Sebuku, South Kalimantan, Indonesia. The screening method started from selection of part of X.
Latifah K Darusman +2 more
doaj +2 more sources
Thiopurine Drugs Repositioned as Tyrosinase Inhibitors [PDF]
International Journal of Molecular Sciences, 2017 Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors.
Joonhyuck Choi, You-Mie Lee, Jun-Goo Jee
core +4 more sources
Thiazolopyrimidine derivatives as novel class of small molecule tyrosinase inhibitor. [PDF]
BMC Chem, 2023 Tyrosinase, the rate-limiting enzyme of melanogenesis, plays a crucial role in hyperpigmentation. As a result, in this study, a novel class of thiazolopyrimidine derivatives was developed and synthesized as tyrosinase inhibitor.
Ghasemi N, Moradi S, Iraji A, Mahdavi M.
europepmc +2 more sources
MoleculesTyrosinase catalyzes the rate-limiting steps of melanin production, posing as an important target for treating skin pigmentation. This study investigates bioactive human tyrosinase inhibitors from Xanthium strumarium L.
Gengxuan Shi +6 more
doaj +2 more sources
Rifampicin is not an inhibitor of tyrosinase
International Journal of Biological Macromolecules, 2022 Rifampicin has been previously described as an inhibitor of tyrosinase (Chai et al., Int. J. Biol. Macromol. 102 (2017) 425-430). However, rifampicin contains a p-diphenol group and compounds with such a moiety have been shown before to reduce tyrosinase-generated o-quinones.
Damian Tarasek, Hubert Wojtasek
openaire +2 more sources
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [PDF]
PeerJ, 2018 Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases.
Qi Li +7 more
doaj +2 more sources
Frontiers in Chemistry, 2022 In order to find potential inhibitors of tyrosinase, two series of pyrrole derivatives A (1–17) and B (1–8) were synthesized and screened for their inhibitory activities on tyrosinase. Most of the 2-cyanopyrrole derivatives exhibited effective inhibitory
Ya-Guang Hu +9 more
doaj +1 more source
Molecules, 2023 Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its inhibitors could be useful in preventing melanin-related diseases.
Jianping Li +5 more
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Tyrosinase-Mediated Synthesis of Nanobody–Cell Conjugates
, 2022 A convenient enzymatic strategy is reported for the modification of cell surfaces. Using a tyrosinase enzyme isolated from Agaricus bisporus, unique tyrosine residues introduced at the C-termini of nanobodies can be site-selectively oxidized to reactive ...
Daniel K. Nomura (198023) +5 more
core +3 more sources
Computational and Structural Biotechnology Journal, 2019 Tyrosinase is a key enzyme responsible for melanin biosynthesis and is effective in protecting skin damage caused by ultraviolet radiation. As part of ongoing efforts to discover potent tyrosinase inhibitors, we systematically designed and synthesized ...
Hee Jin Jung +6 more
doaj +1 more source