Results 1 to 10 of about 2,456,343 (206)
Inhibition mechanism and behaviour of wedelolactone against α-glucosidase [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryThe quest for effective and safe treatments for diabetes mellitus has led to the exploration of natural metabolites as potential α-glucosidase inhibitors.
Jianjun Zhang +4 more
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Rce1: mechanism and inhibition [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2018 Ras converting enzyme 1 (Rce1) is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins, whose members play important roles in cell signaling processes.
Shahienaz E. Hampton +2 more
openaire +2 more sources
Journal of Marine Science and Engineering, 2021 A comparative analysis of the hydrodynamic performance of a planing craft in the monomer-form state (MFS) and trimaran-form state (TFS) was performed, and the inhibition mechanism of twin side-hulls on porpoising instability was evaluated based on the ...
Jiandong Wang +3 more
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Journal of Fungi, 2023 Vanderbylia robiniophila (Huaier in Chinese) has been used as a traditional herbal medicine in China for over 1600 years. However, the secondary metabolites of V. robiniophila have not been systematically examined. Corresponding chemical investigation in
Yuxi Wang +4 more
doaj +1 more source
Chemistry, 2020 The synthesis and corrosion inhibition performance of poly(butylene-succinate)-L-proline (PBSLP) prepared by solution polymerization are reported. PBSLP was characterized by FTIR, XRD, and SEM/energy dispersive X-ray (EDX). PBSLP was used to protect mild
George M. Tsoeunyane +1 more
doaj +1 more source
High-Throughput Mechanism of Inhibition
SLAS Discovery, 2021 Enzymes represent a significant proportion of the druggable genome and constitute a rich source of drug targets. Delivery of a successful program for developing a modulator of enzyme activity requires an understanding of the enzyme's mechanism and the mode of interaction of compounds.
Gareth Davies +4 more
openaire +2 more sources
Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]
, 2016 Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K. +4 more
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Mechanism of Polyphenols Inhibiting Lipid Oxidation and Its Development in Meat Products
Shipin gongye ke-ji, 2022 Polyphenol is a kind of natural non-toxic oxidation inhibitor, which can inhibit lipid oxidation by chelating metal ions, scavenging free radicals and carbonyl compounds.
Songping WANG +5 more
doaj +1 more source
Neural Sampling by Irregular Gating Inhibition of Spiking Neurons and Attractor Networks [PDF]
, 2016 A long tradition in theoretical neuroscience casts sensory processing in the brain as the process of inferring the maximally consistent interpretations of imperfect sensory input.
Indiveri, Giacomo, Muller, Lorenz K.
core +1 more source
A Mechanism for Inhibiting the SUMO Pathway [PDF]
Molecular Cell, 2004 The SUMO pathway parallels the classical ubiquitinylation pathway with three discrete steps: activation involving the enzyme E1, conjugation involving the E2 enzyme UBC9, and substrate modification through the cooperative association of UBC9 and E3 ligases.
Boggio, Roberto +4 more
openaire +2 more sources