Results 31 to 40 of about 2,456,442 (305)

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]

, 2020
Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Arias-Muñoz, Eloisa, Bandau, Susanne, Burgos, Patricia V., Bustamante, Hianara A., Cancino, Jorge, Cerda-Troncoso, Cristóbal, Cereceda, Karina, Cheuquemilla, Yorka, González, Alexis E., Hay, Ronald T., Hernández, Sergio, Kausel, Gudrun, Kerr, Bredford, Mardones, Gonzalo A., Rojas-Fernandez, Alejandro, Soza, Andrea, Valenzuela, Guillermo E.   +16 more
core   +2 more sources

Early redox activities modulate Xenopus tail regeneration. [PDF]

, 2018
Redox state sustained by reactive oxygen species (ROS) is crucial for regeneration; however, the interplay between oxygen (O2), ROS and hypoxia-inducible factors (HIF) remains elusive.
Ferreira, Fernando, Luxardi, Guillaume, Raghunathan, VijayKrishna, Zhao, Min, Zhu, Kan   +4 more
core   +6 more sources

Understanding the Mechanism of Ferroptosis in Neurodegenerative Diseases

Frontiers in Bioscience-Landmark
Neurodegenerative disorders are typified by the progressive degeneration and subsequent apoptosis of neuronal cells. They encompass a spectrum of conditions, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS)
Jiazi Ma, Jianwei Liu, Shangya Chen, Wanxin Zhang, Tian Wang, Mao Cao, Yong Yang, Yilun Du, Guanqun Cui, Zhongjun Du   +9 more
doaj   +1 more source

The Effect of Carbon Dissection of Waste Plastics on Inhibiting the Adhesion of Fine Iron Ore Particles during Hydrogen Reduction

Metals, 2018
In this research, Australian fine iron ore was reduced by combining pressurized and energy-bearing waste plastics in a fluidized bed. This research aims to obtain preferable operating parameters by synthetically researching the effect of temperature ...
Qiyan Xu, Zhuangzhuang Liu, Zhiping Li, Jianjun Wang, Li Zhou   +4 more
doaj   +1 more source

Mixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The formal mechanism of linear mixed and non-competitive enzyme inhibition implies the binding of inhibitors to both the active site of the free enzyme in competition with the substrate, and to an allosteric site on the enzyme-substrate complex. However,
Alessandro Pesaresi
doaj   +1 more source

Inhibition Mechanism of Water-Soluble Chitosan–Curdlan Composite Coating on the Postharvest Pathogens of Serratia marcescens and Pseudomonas syringae in Cherry Tomatoes

Microorganisms
Cherry tomatoes, a very popular fruit, are highly susceptible to microbial infestation, which cause significant economic losses. In order to preserve cherry tomatoes better, we treat them with a Chitosan (CTS) and Curdlan (CUR) composite coating.
Kejing Yan, Kunyu Liu, Jiaqi Chang, Ziyu Jing, Jiasi Li, Youwei Yu, Shaoying Zhang   +6 more
doaj   +1 more source

Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type PhX (X = COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding derivatives with sulphur(VI)-based ZBGs (X = SO3H, SO2NH2, SO2NHNH2, SO2NHOH, SO2NHOMe) were ...
Claudiu T. Supuran
doaj   +1 more source

Metformin reverses development of pulmonary hypertension via aromatase inhibition [PDF]

, 2016
Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP ...
Dean, Afshan, Loughlin, Lynn, MacLean, Margaret R., Nilsen, Margaret, Salt, Ian P.   +4 more
core   +2 more sources

Mechanism of Acetophenone Fumigation to Inhibit Postharvest Botrytis cinerea in Grape

Shipin gongye ke-ji
Gray mold is one of the main diseases in postharvest storage of grape. To explore the inhibition mechanism of acetophenone fumigation on Botrytis cinerea.
Wei HUANG, Miaomiao ZHANG, Ning WANG, Faqiang ZHAN, Fengjuan LIU, Suling WANG, Longyuan WU, Qiyong TANG, Lijuan ZHANG, Wei WANG   +9 more
doaj   +1 more source

Elucidating the Inhibitory Effect of Resveratrol and Its Structural Analogs on Selected Nucleotide-Related Enzymes

Biomolecules, 2020
Resveratrol, the most widely studied natural phytochemical, has been shown to interact with different target proteins. Previous studies show that resveratrol binds and inhibits DNA polymerases and some other enzymes; however, the binding and functioning ...
Yifei Wu, Tze-chen Hsieh, Joseph M. Wu, Xiaoxiao Wang, Joshua S. Christopher, Amanda H. Pham, Justin David-Li Swaby, Lei Lou, Zhong-Ru Xie   +8 more
doaj   +1 more source