Results 51 to 60 of about 2,456,442 (305)

A Cellular Mechanism for Prepulse Inhibition [PDF]

Neuron, 2003
In prepulse inhibition (PPI), startle responses to sudden, unexpected stimuli are markedly attenuated if immediately preceded by a weak stimulus of almost any modality. This experimental paradigm exposes a potent inhibitory process, present in nervous systems from invertebrates to humans, that is widely considered to play an important role in reducing ...
Frost, William N, Tian, Li-Ming, Hoppe, Travis A, Mongeluzi, Donna L, Wang, Jean   +4 more
openaire   +2 more sources

Grape Skin Polyphenols (GSPs) Inhibit the Migration of Mouse Mammary Carcinoma 4T1 Cells in Vitro

Cancer Biology & Medicine, 2011
OBJECTIVE 1) To study the efficacy of GSPs on the migration of highly metastatic mammary carcinoma cells and 2) To investigate inhibition mechanisms. METHODS Cell migration was assessed using a 24-well transwell assay.
Qiu-yu Chen, Zhi-qiang Liang, Tao Sun, Xiang-jun Sun
doaj   +1 more source

Studies on the inhibitory effect of isavuconazole on flumatinib metabolism in vitro and in vivo

Frontiers in Pharmacology, 2023
As the validated agent for the treatment of chronic myelogenous leukemia (CML), flumatinib is a novel oral tyrosine kinase inhibitor (TKI) with higher potency and selectivity for BCR-ABL1 kinase compared to imatinib.
Ya-nan Liu, Ya-nan Liu, Xinhao Xu, Xinhao Xu, Jingjing Nie, Jingjing Nie, Yingying Hu, Xuegu Xu, Ren-ai Xu, Xiaoxiang Du   +9 more
doaj   +1 more source

Inhibition and Mechanism of HDAC8 Revisited [PDF]

Journal of the American Chemical Society, 2014
Histone deacetylases (HDACs) have found intense interest as drug targets for a variety of diseases, but there is disagreement about basic aspects of the inhibition and mechanism of HDACs. QM/MM calculations of HDAC8 including a large QM region provide a model that is consistent with the available crystal structures and structure-activity relationships ...
Chen, Kai, Zhang, Xiaoxiao, Wu, Yun-Dong, Wiest, Olaf   +3 more
openaire   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Binding Interaction of Betulinic Acid to α-Glucosidase and Its Alleviation on Postprandial Hyperglycemia

Molecules, 2022
Inhibiting the intestinal α-glucosidase can effectively control postprandial hyperglycemia for type 2 diabetes mellitus (T2DM) treatment. In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely ...
Shaodan Chen, Bing Lin, Jiangyong Gu, Tianqiao Yong, Xiong Gao, Yizhen Xie, Chun Xiao, Janis Yaxian Zhan, Qingping Wu   +8 more
doaj   +1 more source

ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer\u27s Disease. [PDF]

, 2017
Alzheimer\u27s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear.
Aschmies, Suzan, Ashok, Annie, Chin, Jeannie, Corbett, Brian F, Fu, Chia-Hsuan, Hazra, Anupam, Iascone, Daniel M, Nestler, Eric J, Petrof, Iraklis, Pyfer, Mark S, Stephens, Gabriel S, Tosi, Umberto, You, Jason C, Zhang, Xiaohong, Zhao, Lijuan   +14 more
core   +1 more source

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Identification of the inhibition mechanism of carbonic anhydrase II by fructooligosaccharides

Frontiers in Molecular Biosciences
Polygonatum sibiricum (P. sibiricum), recognized as a precious nourishing Chinese traditional medicine, exhibits the pharmacological effect of anti-aging.
Yue Mu, Qingyang Meng, Xinyi Fan, Shuyun Xi, Zhongli Xiong, Yihua Wang, Yanling Huang, Zhen Liu   +7 more
doaj   +1 more source

The C-terminus of p63 contains multiple regulatory elements with different functions [PDF]

, 2010
The transcription factor p63 is expressed as at least six different isoforms, of which two have been assigned critical biological roles within ectodermal development and skin stem cell biology on the one hand and supervision of the genetic stability of ...
Candi, Eleonora, Durst, Florian, Dötsch, Volker, Melino, Gennaro, Ou, Horng Der, Rajalingam, Krishnaraj, Schäfer, Birgit, Straub, Wesley E., Weber, Tobias Alexander   +8 more
core   +2 more sources