Results 71 to 80 of about 5,491,440 (299)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Experimental study on in-situ inhibition mechanism of epigenetic biogenic H2S in coal seam

Meitan xuebao
During coalbed methane (CBM) drainage and production processes, both high-sulfur coal and high-sulfate coal seam water are prone to generate epigenetic biogenic H2S.
Yixuan ZHOU, Wenjie ZHAO, Mengjiao QI, Can LÜ   +3 more
doaj   +1 more source

Discovery and Characterization of the Naturally Occurring Inhibitors Against Human Pancreatic Lipase in Ampelopsis grossedentata

Frontiers in Nutrition, 2022
Pancreatic lipase (PL) inhibitor therapy has been validated as an efficacious way for preventing and treating obesity and overweight. In the past few decades, porcine PL (pPL) is widely used as the enzyme source for screening the PL inhibitors, which ...
Xiao-Ya Qin, Xiao-Ya Qin, Xu-Dong Hou, Xu-Dong Hou, Guang-Hao Zhu, Yuan Xiong, Yun-Qing Song, Liang Zhu, Dong-Fang Zhao, Shou-Ning Jia, Jie Hou, Hui Tang, Guang-Bo Ge   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Identification and characterization of a broadly neutralizing and protective nanobody against the HA1 domain of H5 avian influenza virus hemagglutinin

Journal of Virology
The highly pathogenic avian influenza viruses (HPAIVs) of subtype H5, particularly those of the currently circulating clades 2.3.2.1 and 2.3.4.4, are largely responsible for the sporadic human infections that frequently present with a high case fatality ...
Siqi Xu, Yutong Liu, Chenying Luo, Mengruo Zhou, Ke Wang, Qianmei Xie, Qi Zhang, Qinying Zhang, Qianyu Li, Zhichao Pan, Saixiang Feng, Ming Liao   +11 more
doaj   +1 more source

Mechanism of Inhibition of Granulopoiesis by Ethanol

Experimental Biology and Medicine, 1984
The mechanism of inhibition of neutrophilic granulopoiesis by ethanol has not been well characterized. Possible mechanisms investigated include: (a) a direct toxic effect on the granulocyte-macrophage cluster-colony forming unit (CFU-GM), and/or (b) inhibition of production of CFU-GM proliferation stimulating factor activity (CSA) from T lymphocytes (T
P S, Imperia, G, Chikkappa, P G, Phillips   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism

, 1992
Eicosanoids, in particular prostaglandin E2 (PGE2), are potent inhibitors of a number of immune responses, including lymphocyte proliferation. We have previously shown that fatty acids, especially polyunsaturated fatty acids (PUFA), inhibit mitogen ...
Calder, P.C., Newsholme, E.A., Bevan, S.J.   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multistep growth of amyloid intermediates and its inhibition toward exploring therapeutic way: A case study using insulin B chain and fibrinogen

Biophysics and Physicobiology, 2022
It is crucial to understand the mechanism of amyloid fibril formation for the development of the therapeutic ways against amyloidoses and neurodegenerative diseases.
Naoki Yamamoto, Eri Chatani
doaj   +1 more source