Results 91 to 100 of about 5,491,440 (299)

The Effect of Pressurized Decarbonization of CO on Inhibiting the Adhesion of Fine Iron Ore Particles

Metals, 2018
In this research, Australian fine iron ore is reduced by pressured carbon monoxide in a fluidized bed. This research aims to obtain the influence law of gas linear velocity, reduction pressure, reduction temperature, particle size, and reduction time on ...
Qiyan Xu, Zhiping Li, Zhuangzhuang Liu, Jianjun Wang, Haichuan Wang   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Frontiers in Chemistry, 2018
Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are ...
Alen Albreht, Irena Vovk, Janez Mavri, Jose Marco-Contelles, Rona R. Ramsay   +4 more
doaj   +1 more source

Molecular Insight of the Possible Inhibition Mechanism of Therapeutic Cephalosporin Derivatives against Human Glutathione Reductase Enzyme

Cumhuriyet Science Journal, 2020
Glutathione reductase is a key enzyme for glutathione metabolism. Inhibition of the enzyme activity related to various health problems. Therefore, determination of inhibitors of the enzyme and its possible inhibition mechanism are quite important.
Muhammet Karaman
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effect of Genistein on Starch Digestion In Vitro and Its Mechanism of Action

Foods
The digestive properties of starch are crucial in determining postprandial glycaemic excursions. Genistein, an active phytoestrogen, has the potential to influence starch digestion rates.
Jianhui Jia, Boxin Dou, Man Gao, Chujia Zhang, Ying Liu, Na Zhang   +5 more
doaj   +1 more source

A class of carbonic anhydrase I – selective activators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained derivatives were assayed as activators of the enzyme carbonic anhydrase (CA, EC 4.2.1.1), due to the fact that ...
Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu, Claudiu T. Supuran   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experimental and Numerical Study on Flame Inhibition Mechanism of Methane–Coal Dust Hybrid Explosion by Ultrafine Water Mist with Novel Chemical Additives

Fire
Coal mining frequently sees explosions caused by methane/coal dust mixtures, resulting in significant harm to people and property damage. This study utilized the Hartmann pipe experiment to investigate the inhibition mechanisms of ultrafine water mist ...
Li Liu, Yongheng Jing, Le Sun, Yao Tang
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source