Results 101 to 110 of about 2,456,442 (305)

The Effect of Pressurized Decarbonization of CO on Inhibiting the Adhesion of Fine Iron Ore Particles

Metals, 2018
In this research, Australian fine iron ore is reduced by pressured carbon monoxide in a fluidized bed. This research aims to obtain the influence law of gas linear velocity, reduction pressure, reduction temperature, particle size, and reduction time on ...
Qiyan Xu, Zhiping Li, Zhuangzhuang Liu, Jianjun Wang, Haichuan Wang   +4 more
doaj   +1 more source

Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications

, 2014
A recently experimentally observed biochemical "threshold filtering" mechanism by processes catalyzed by the enzyme malate dehydrogenase is explained in terms of a model that incorporates an unusual mechanism of inhibition of this enzyme that has a ...
Domanskyi, Sergii, Holade, Yaovi, Katz, Evgeny, Mailloux, Shay, Privman, Vladimir   +4 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effect of Genistein on Starch Digestion In Vitro and Its Mechanism of Action

Foods
The digestive properties of starch are crucial in determining postprandial glycaemic excursions. Genistein, an active phytoestrogen, has the potential to influence starch digestion rates.
Jianhui Jia, Boxin Dou, Man Gao, Chujia Zhang, Ying Liu, Na Zhang   +5 more
doaj   +1 more source

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Frontiers in Chemistry, 2018
Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are ...
Alen Albreht, Irena Vovk, Janez Mavri, Jose Marco-Contelles, Rona R. Ramsay   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental and Numerical Study on Flame Inhibition Mechanism of Methane–Coal Dust Hybrid Explosion by Ultrafine Water Mist with Novel Chemical Additives

Fire
Coal mining frequently sees explosions caused by methane/coal dust mixtures, resulting in significant harm to people and property damage. This study utilized the Hartmann pipe experiment to investigate the inhibition mechanisms of ultrafine water mist ...
Li Liu, Yongheng Jing, Le Sun, Yao Tang
doaj   +1 more source

A class of carbonic anhydrase I – selective activators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained derivatives were assayed as activators of the enzyme carbonic anhydrase (CA, EC 4.2.1.1), due to the fact that ...
Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu, Claudiu T. Supuran   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source