Results 101 to 110 of about 5,491,440 (299)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Inhibition of pitting on carbon steel [PDF]
, 2011 Carbon dioxide and hydrogen sulphide pitting related failures are a prime concern in oil and gas internal pipelines. Often, these types of failure have a great impact on safety and environmental matters and can cause severe financial consequences to the
Ismail, Ismarullizam Mohd
core +3 more sources
Mechanism of Fast Axonal Transport Inhibition by Polyglutamine Expanded Huntingtin.
, 2014 Mechanism of Fast Axonal Transport Inhibition by Polyglutamine Expanded ...
Sarah L. Pollema (7973459)
core +2 more sources
Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C [PDF]
, 1994 Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.
Grünbaum, L. +4 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Drug Interactions of Imperatorin and Curcumin on Macitentan in vitro and in vivo
Drug Design, Development and TherapyHualu Wu,1 Qian Liu,2 Yuxin Shen,1 He Qi,3 Jiade Zhao,3 Qiaoying Li,4 Hailun Xia,1 Ren-Ai Xu,1 Lu Shi1 1Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of ...
Wu H +8 more
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
ERP correlates of forgetting: an investigation of resource allocation as a potential neural mechanism behind retrieval-induced forgetting [PDF]
, 2012 The present study was aimed at investigating a potential mechanism behind retrieval-induced forgetting that we have termed resource allocation. Three experiments were designed around the notion that increasing the number memories associated with one ...
Walters, Marie
core +2 more sources