Results 21 to 30 of about 5,491,440 (299)

Predicting the mechanism of phospholipidosis [PDF]

, 2012
The mechanism of phospholipidosis is still not well understood. Numerous different mechanisms have been proposed, varying from direct inhibition of the breakdown of phospholipids to the binding of a drug compound to the phospholipid, preventing breakdown.
Mitchell, JBO, Glen, RC, Glen Robert C, Nigsch Florian, Mussa, HY, Robert Lowe, Florian Nigsch, Robert C Glen, Nigsch, F, Mussa, Hamse Y., Lowe, R, Glen, Robert C., Lowe Robert, John BO Mitchell, Mitchell John BO, Nigsch, Florian, Lowe, Robert, Mussa Hamse Y, Hamse Y Mussa, Mitchell, John B. O., Mitchell, John B. O.; id_orcid   +20 more
core   +5 more sources

Tyrosinase Inhibition Ability Provided by Hop Tannins: A Mechanistic Investigation

Biology and Life Sciences Forum, 2021
The hop is rich in tannins used as a conventional additive in the beer industry, but other applications are limited. This study investigated the tyrosinase inhibition activity of extracted hop tannins and the associated structure–function activity.
Jiaman Liu, Yanbiao Chen, Xinxin Zhang, Jie Zheng, Jiaying Wang, Weiying Hu, Bo Teng   +6 more
doaj   +1 more source

Inhibition and Mechanism of HDAC8 Revisited [PDF]

Journal of the American Chemical Society, 2014
Histone deacetylases (HDACs) have found intense interest as drug targets for a variety of diseases, but there is disagreement about basic aspects of the inhibition and mechanism of HDACs. QM/MM calculations of HDAC8 including a large QM region provide a model that is consistent with the available crystal structures and structure-activity relationships ...
Chen, Kai, Zhang, Xiaoxiao, Wu, Yun-Dong, Wiest, Olaf   +3 more
openaire   +2 more sources

Feedforward inhibition and synaptic scaling - two sides of the same coin? [PDF]

, 2012
Feedforward inhibition and synaptic scaling are important adaptive processes that control the total input a neuron can receive from its afferents. While often studied in isolation, the two have been reported to co-occur in various brain regions.
Cristina Savin, Keck, Christian, Savin Cristina, Lücke, Jörg, Cristina Savin (175862), Jörg Lücke (175863), Christian Keck (175861), Christian Keck, Jörg Lücke, Savin, Cristina, Keck Christian, Lücke Jörg   +11 more
core   +2 more sources

Insights into the Inhibitory Mechanism of Viniferifuran on Xanthine Oxidase by Multiple Spectroscopic Techniques and Molecular Docking

Molecules, 2022
Viniferifuran was investigated for its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme catalyzing xanthine to uric acid. An enzyme kinetics analysis showed that viniferifuran possessed a strong inhibition on XO in a typical anti ...
Yaxin Yang, Qian Chen, Shiyang Ruan, Junli Ao, Shang-Gao Liao   +4 more
doaj   +1 more source

Ferroptosis Inhibition: Mechanisms and Opportunities

Trends in Pharmacological Sciences, 2017
The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable attention owing to its putative involvement in diverse ...
Friedmann Angeli, J.P.F., Shah, R., Pratt, D.A., Conrad, M.   +3 more
openaire   +4 more sources

Insight into the Molecular Mechanism for the Discrepant Inhibition of Microcystins (MCLR, LA, LF, LW, LY) on Protein Phosphatase 2A

Toxins, 2022
Microcystins (MCs) exhibit diversified inhibition effects on protein phosphatases (PPs) due to their structural differences. To fully evaluate the potential mechanism for the discrepant inhibition effects, the five most frequent MCs with varying residues
Yixue Xu, Jiyuan Cui, Huiqun Yu, Wansong Zong   +3 more
doaj   +1 more source

Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism [PDF]

, 1992
3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions.
Seifert, Roland, Jürgen Ervens, Roland Seifert, Ervens, J.   +3 more
core   +1 more source

Screening and Analysis of Antifungal Strains Bacillus subtilis JF-4 and B. amylum JF-5 for the Biological Control of Fusarium Wilt of Banana

Journal of Fungi, 2023
Purpose: This study aimed to identify the antagonistic bacteria from the rhizosphere of healthy bananas that can effectively suppress the Fusarium wilt of banana, and to further investigate the inhibitory mechanism.
Yajie Duan, Zhencai Pang, Shunli Yin, Weijun Xiao, Huigang Hu, Jianghui Xie   +5 more
doaj   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B., Lambert, Jeremy J., Delia Belelli, Jeremy J. Lambert, Belelli, Delia, Murray B. Herd   +5 more
core   +1 more source