Results 11 to 20 of about 5,491,440 (299)
Rce1: mechanism and inhibition [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2018 Ras converting enzyme 1 (Rce1) is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins, whose members play important roles in cell signaling processes.
Shahienaz E. Hampton +2 more
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Computational Insights into the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol [PDF]
, 2023 Xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme found in many living organisms. Its function is to convert hypoxanthine to xanthine and subsequently to urate, which are the final steps in purine elimination in humans.
G. Andrés, Cisneros +2 more
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High-Throughput Mechanism of Inhibition
SLAS Discovery, 2021 Enzymes represent a significant proportion of the druggable genome and constitute a rich source of drug targets. Delivery of a successful program for developing a modulator of enzyme activity requires an understanding of the enzyme's mechanism and the mode of interaction of compounds.
Gareth Davies +4 more
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Inhibition in time-based visual selection : strategic or by default? [PDF]
, 2015 The Visual Marking mechanism (Watson & Humphreys, 1997) allows new objects to be prioritized by applying top-down inhibition to a set of previewed distractors, increasing the efficiency of future visual search.
Zupan, Zorana +2 more
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What do we really know about cognitive inhibition? Task demands and inhibitory effects across a range of memory and behavioural tasks [PDF]
, 2015 The authors (SN, principal investigator and MDM as co-investigator) received funding from the British Academy for this research (http://www.britac.ac.uk/).
Saima Noreen (462029) +9 more
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A Mechanism for Inhibiting the SUMO Pathway [PDF]
Molecular Cell, 2004 The SUMO pathway parallels the classical ubiquitinylation pathway with three discrete steps: activation involving the enzyme E1, conjugation involving the E2 enzyme UBC9, and substrate modification through the cooperative association of UBC9 and E3 ligases.
Boggio, Roberto +4 more
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Computational Evaluation of the COVID-19 3c-like Protease Inhibition Mechanism, and Drug Repurposing Screening [PDF]
, 2020 The rapid spread of the COVID-19 outbreak is now a global threat with over a million diagnosed cases and more than 70 thousand deaths. Specific treatments and effective drugs regarding such disease are in urgent need.
Wenlang, Liu +3 more
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Mechanisms and inhibition of HIV integration [PDF]
Drug Discovery Today: Disease Mechanisms, 2006 HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed ...
Christophe, Marchand +3 more
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Basic Mechanisms of JAK Inhibition
Mediterranean Journal of Rheumatology, 2020 Over recent decades, treatment options for inflammatory diseases such as rheumatoid arthritis (RA) have increased dramatically. These range from orally available steroids and conventional synthetic disease modifying drugs (csDMARDs) to parenteral biological therapies (bDMARDs).
Lin, Chung MA +2 more
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THE MECHANISM OF THE INHIBITION OF HEMOLYSIS [PDF]
Journal of General Physiology, 1943 1. When digitonin is the lysin, the inhibitory power of sols of cholesterol and related substances depends primarily on a normal, as opposed to an epi, configuration of H and OH at C3. Subsidiary inhibitory effects depend on whether the double bond of cholesterol at C5 is saturated or not, and a trans hydrogen at C5 is associated with a greater ...
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