Results 41 to 50 of about 22,637 (249)

Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet

Journal of Chemistry, 2018
Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in ...
Wen-Ying Huang, Hui-Ju Chen, Chia-Ching Lin, Chin-Shuh Chen, Yung-Sheng Lin   +4 more
doaj   +1 more source

Synthesis and Tyrosinase Inhibitory Activity of (E)-5-Benzyl-7- (3-Bromobenzylidene)-3-(3-Bromophenyl)-2-Phenyl-3,3a, 4,5,6,7-Hexahydro-2H-Pyrazolo[4,3-c]Pyridine

Jurnal Kimia Sains dan Aplikasi, 2022
The tyrosinase enzyme plays an essential role in the pigmentation of human skin, fruits, and vegetables. It has been tied with several human skin diseases and post-harvest problems.
Nelly Oscifiani, Noval Herfindo, Rahayu Rahayu, Neni Frimayanti, Adel Zamri   +4 more
doaj   +1 more source

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy

Supramolecular Materials
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising ...
Yongsheng Li, Kan Yang, Luyang Zhao
doaj   +1 more source

Thiopurine Drugs Repositioned as Tyrosinase Inhibitors [PDF]

International Journal of Molecular Sciences, 2017
Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors.
Choi, Joonhyuck, Lee, You-Mie, Jee, Jun-Goo   +2 more
openaire   +2 more sources

Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

Journal of Chemistry, 2013
In continuation with our research program, in search of potent enzyme tyrosinase inhibitor, a series of synthesized 2,5-disubstituted 1,3,4-oxadiazoles have been evaluated for enzyme tyrosinase inhibitory activity.
Ramesh L. Sawant, Prashant D. Lanke, Jyoti B. Wadekar   +2 more
doaj   +1 more source

Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies. [PDF]

PLoS ONE, 2017
The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to ...
Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip   +7 more
doaj   +1 more source

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives

Pharmaceuticals, 2023
Heterocyclic nuclei have shown a wide variety of biological activities, highlighting their importance in drug discovery. Derivatives of 2,4-subsituted thiazolidine have a structural similarity with the substrates of tyrosinase enzymes. Hence, they can be
Muhammad Kazim Zargaham, Madiha Ahmed, Nosheen Akhtar, Zaman Ashraf, Mostafa A. Abdel-Maksoud, Mohammed Aufy, Humaira Nadeem   +6 more
doaj   +1 more source

Amperometric tyrosinase based biosensor using an electrogenerated polythiophene film as an entrapment support [PDF]

, 2003
International audienceAn amperometric enzyme sensor using tyrosinase, also called polyphenol oxidase (PPO), was constructed for determination of phenolic compounds and herbicides.
Fabiano, Silvia, Tran-Minh, Canh, Védrine, Christophe   +2 more
core   +2 more sources

Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways

Medicines, 2019
Background: Liquiritin (LQ) and its aglycone, liquiritigenin (LQG), are major flavonoids in licorice root (Glycyrrhiza spp.). Our preliminary screening identified LQ and LQG, which promote melanin synthesis in the melanoma cells.
Takuhiro Uto, Tomoe Ohta, Akihisa Yamashita, Shunsuke Fujii, Yukihiro Shoyama   +4 more
doaj   +1 more source

Screening of Marine-Derived Fungi Extracts as Antioxidant, Tyrosinase Inhibitor, and Antiglycation

Squalen, 2019
Marine-derived fungi are of great interest as new promising sources of bioactive secondary metabolites. The aim of this study was to determine the antioxidant activity, tyrosinase inhibitor and antiglycation of marine-derrived fungi collected from ...
Muhamad Nursid, Endar Marraskuranto, Dilaika Septorini, Irmanida Batubara   +3 more
doaj   +1 more source