Results 41 to 50 of about 12,040 (235)
Journal of Chemistry, 2013 In continuation with our research program, in search of potent enzyme tyrosinase inhibitor, a series of synthesized 2,5-disubstituted 1,3,4-oxadiazoles have been evaluated for enzyme tyrosinase inhibitory activity.
Ramesh L. Sawant +2 more
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Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways
Medicines, 2019 Background: Liquiritin (LQ) and its aglycone, liquiritigenin (LQG), are major flavonoids in licorice root (Glycyrrhiza spp.). Our preliminary screening identified LQ and LQG, which promote melanin synthesis in the melanoma cells.
Takuhiro Uto +4 more
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Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies. [PDF]
PLoS ONE, 2017 The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to ...
Zaman Ashraf +7 more
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Pharmaceuticals, 2023 Heterocyclic nuclei have shown a wide variety of biological activities, highlighting their importance in drug discovery. Derivatives of 2,4-subsituted thiazolidine have a structural similarity with the substrates of tyrosinase enzymes. Hence, they can be
Muhammad Kazim Zargaham +6 more
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Thiopurine Drugs Repositioned as Tyrosinase Inhibitors [PDF]
International Journal of Molecular Sciences, 2017 Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors.
Joonhyuck Choi, You-Mie Lee, Jun-Goo Jee
openaire +2 more sources
, 2019 Hyperpigmentation is an event that occurs due to excessive production of skin pigments, where the presence of melanin. Belimbing wuluh as Indonesian plant is rich compounds that function as antioxidants and tyrosinase inhibitor.
Ririn Suharsanti 1 *, Nining Sugihartini 2, Endang Lukitaningsih 3, Muhammad Ryan Radix Rahardhian 1
core +1 more source
Rosa × damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition
Frontiers in PharmacologyTyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving increasing attention. Rosa × damascena Herrm. essential oil (RDEO), as important functional metabolites, was widely known due to its biological activities.
Qiuyan Wu +4 more
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Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
, 2017 Sargassum plagyophyllum from Sargassaceae family contains various bioactive compounds, namelyphlorotannin which is reported as an antioxidant and tyrosinase inhibitor.
Ayun Erwina Arifianti +5 more
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Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source