Results 41 to 50 of about 568,389 (237)

Hen egg white lysozyme as an inhibitor of mushroom tyrosinase [PDF]

, 2006
We report a kinetics study on hen egg white lysozyme’s (HEWL) inhibitory effect on mushroom tyrosinase catalysis of 3-(3,4-dihydroxyphenyl)-l-alanine (l-DOPA) or l-tyrosine.
Li, Bin, Paskewitz, Susan M., Huang, Yu
core   +1 more source

Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways

Medicines, 2019
Background: Liquiritin (LQ) and its aglycone, liquiritigenin (LQG), are major flavonoids in licorice root (Glycyrrhiza spp.). Our preliminary screening identified LQ and LQG, which promote melanin synthesis in the melanoma cells.
Takuhiro Uto, Tomoe Ohta, Akihisa Yamashita, Shunsuke Fujii, Yukihiro Shoyama   +4 more
doaj   +1 more source

Purification and Determination of the Chemical Structure of the Tyrosinase Inhibitor Produced by Trichoderma viride Strain H1-7 from a Marine Environment

, 2008
Tyrosinase is a key enzyme in the synthesis of melanin and is widely distributed in animals, plants, and microorganisms. As excessive melanin production causes not only hyperpigmenting effects on human skin but also melanosis in various foods, an ...
Miyamoto, Katsuhiro, 濱田, 奈保子, Imada, Chiaki, Kobayashi, Takeshi, コバヤシ, タケシ, Hamada, Naoko, イマダ, チアキ, 小林, 武志, Yamada, Katsuhisa, ハマダ, ナオコ, 今田, 千秋, Tsuchiya, Takahiro, Satoh, Naoko, 佐藤, 奈保子, Minoura, Katsuhiko, Usami, Yoshihide, Tsujibo, Hiroshi, サトウ, ナオコ   +17 more
core   +1 more source

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives

Pharmaceuticals, 2023
Heterocyclic nuclei have shown a wide variety of biological activities, highlighting their importance in drug discovery. Derivatives of 2,4-subsituted thiazolidine have a structural similarity with the substrates of tyrosinase enzymes. Hence, they can be
Muhammad Kazim Zargaham, Madiha Ahmed, Nosheen Akhtar, Zaman Ashraf, Mostafa A. Abdel-Maksoud, Mohammed Aufy, Humaira Nadeem   +6 more
doaj   +1 more source

Rhododendrol glycosides as stereospecific tyrosinase inhibitors [PDF]

Bioorganic & Medicinal Chemistry, 2015
Rhododendrol derivatives 3-12 have been synthesized in six steps, including aldol condensation and/or trichloroacetimidate glycosylation as the key reactions. Each derivative showed effective inhibition of tyrosinase-catalyzed oxidation processes. In particular, a series of synthetic derivatives having an R-stereogenic center at C-2 proved to be more ...
Takehiro, Iwadate, Ken-ichi, Nihei
openaire   +2 more sources

Screening of Marine-Derived Fungi Extracts as Antioxidant, Tyrosinase Inhibitor, and Antiglycation

Squalen, 2019
Marine-derived fungi are of great interest as new promising sources of bioactive secondary metabolites. The aim of this study was to determine the antioxidant activity, tyrosinase inhibitor and antiglycation of marine-derrived fungi collected from ...
Muhamad Nursid, Endar Marraskuranto, Dilaika Septorini, Irmanida Batubara   +3 more
doaj   +1 more source

Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies. [PDF]

PLoS ONE, 2017
The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to ...
Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip   +7 more
doaj   +1 more source

Rosa × damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition

Frontiers in Pharmacology
Tyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving increasing attention. Rosa × damascena Herrm. essential oil (RDEO), as important functional metabolites, was widely known due to its biological activities.
Qiuyan Wu, Wanting Fang, Hao Liu, Zhong Liu, Xuetao Xu   +4 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation

, 2014
Tyrosinase is an enzyme widely distributed in the biosphere. It is one of a group of proteins with a strongly conserved bicopper active centre able to bind molecular oxygen.

core   +1 more source