Results 21 to 30 of about 568,389 (237)

Benzylidene-6-hydroxy-3,4-dihydronaphthalenone chalconoids as potent tyrosinase inhibitors

Research in Pharmaceutical Sciences, 2021
Background and purpose: Tyrosinase enzyme has a key role in melanin biosynthesis by converting tyrosine into dopaquinone. It also participates in the enzymatic browning of vegetables by polyphenol oxidation. Therefore, tyrosinase inhibitors are useful in
Sara Ranjbar, Mehraneh Kamarei, Mahsima Khoshneviszadeh, Hona Hosseinpoor, Najmeh Edraki, Mehdi Khoshneviszadeh   +5 more
doaj   +1 more source

A comprehensive review on tyrosinase inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose,
Samaneh Zolghadri, Asieh Bahrami, Mahmud Tareq Hassan Khan, J. Munoz-Munoz, F. Garcia-Molina, F. Garcia-Canovas, Ali Akbar Saboury   +6 more
openaire   +3 more sources

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone [PDF]

, 2011
Tyrosinase catalyzes the conversion of phenolic compounds into their quinone derivatives, which are precursors for the formation of melanin, a ubiquitous pigment in living organisms.
Dijkstra, B.W., Dijkstra, Bauke W., Weijn, A., Bauke W. Dijkstra, Amrah Weijn, Wangsa T. Ismaya, Ismaya, Wangsa T.,, Rozeboom, Henriette J.; id_orcid, Dijkstra, Bauke W.,, Rozeboom, H.J., Jurriaan J. Mes, Harry J. Wichers, Ismaya, Wangsa T., Weijn, Amrah,, Mes, J.J., Ismaya, W.T., Fusetti, F., Wichers, Harry J.,, Fabrizia Fusetti, Mes, Jurriaan J., Fusetti, Fabrizia,, Wichers, Harry J., Fusetti, Fabrizia, Mes, Jurriaan J.,, Wichers, H.J., Rozeboom, Henriette J., Henriëtte J. Rozeboom, Rozeboom, Henriëtte J.,, Weijn, Amrah   +28 more
core   +3 more sources

Tyrosinase-Catalyzed Peptide Macrocyclization for mRNA Display

, 2023
mRNA display of macrocyclic peptides has proven itself to be a powerful technique to discover high-affinity ligands for a protein target. However, only a limited number of cyclization chemistries are known to be compatible with mRNA display.
Albert A. Bowers, Rodney Park, Albert A. Bowers (1635184), Matthew C. Fleming (12511044), Rodney Park (12034850), Matthew M. Bowler (11973582), Konstantin I. Popov (6519812), Matthew M. Bowler, Konstantin I. Popov, Matthew C. Fleming   +9 more
core   +1 more source

Antityrosinase activity of Euphorbia characias extracts [PDF]

PeerJ, 2015
Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents.
Francesca Pintus, Delia Spanò, Angela Corona, Rosaria Medda   +3 more
doaj   +2 more sources

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Christopher Cheng, Elena Sviderskaya, Sviderskaya, EV, Lam, RY, Zhi-Xiu Lin, Lin, ZX, Rosanna Lam, Cheng, CH   +7 more
core   +1 more source

Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation

Molecules, 2017
Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products.
You Chul Chung, Seoyeon Kim, Jin Hwa Kim, Geun Soo Lee, Jung No Lee, Nam Ho Lee, Chang-Gu Hyun   +6 more
doaj   +1 more source

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

Molecules, 2018
In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities.
Chang Seok Kim, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hee Jin Jung, Hyung Ryong Moon   +7 more
doaj   +1 more source

A Competitive Inhibitor of Tyrosinase [PDF]

Australian Journal of Biological Sciences, 1951
The kinetics of the activation of catechol by tyrosinase prepared from the potato and the mushroom, and of its inhibition by sodium m-hydroxybenzoate, have been studied. The enzyme-substrate dissociation constants differed markedly between the two enzyme sources (K.
openaire   +2 more sources

Phlorotannins Derived From the Brown Alga as Tyrosinase Inhibitors

Natural Product Communications, 2021
Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase
Hideyuki Kurihara, Kazuki Kujira
doaj   +1 more source