Results 61 to 70 of about 39,961 (248)

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Potensi Sinamaldehid sebagai Anti Hiperpigmentasi secara In Silico

Jurnal Ilmiah Medicamento, 2021
Permasalahan kulit yang sering ditemui yaitu hiperpigmentasi yang terjadi akibat adanya sintesis melanin berlebihan yang menyebabkan penggelapan warna kulit.
Ni Made Gani Pratiwi, Ni Made Atika Saraswati, Ni Made Irma Febby Prasasti Dewi, Luh Pande Putu Tirta   +3 more
doaj  

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Analysis of the Cre-mediated recombinant expression in embryonic Ai14;RPE-Tyrosinase-CreEr^T2 mice.

, 2018
A: Fluorescent flatmount image showing the uniform distribution of tdTomato expressing cells throughout the RPE of an E17.5 Ai14;RPE-Tyrosinase-CreErT2 embryo. Outline of the RPE indicated by the solid line.
Kapil Bharti (153586), Nathan Hotaling (4625557), Maria Campos (428575), Sarita Rani Patnaik (5979245), Helen Louise May-Simera (5979248), Sandra Schneider (143914)   +5 more
core   +1 more source

Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Membranes
Lysosomal degradation of tyrosinase, a pivotal enzyme in melanin synthesis, negatively impacts melanogenesis in melanocytes. Nevertheless, the precise molecular mechanisms by which lysosomes target tyrosinase have remained elusive. Here, we identify RING
Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C. J. M. D. S. Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita   +9 more
doaj   +1 more source

Optimization of bioactive compounds extraction from Rosa canina L. pseudofruit through the action of two hydrolytic enzyme preparations

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKROUND The pseudo‐fruit of Rosa canina L. is a rich source of bioactive compounds with antioxidant, anti‐inflammatory, anti‐cancer, anti‐diabetic, anti‐aging, and antimicrobial activities. The aim of the present study is the optimization of a green process based on the action of two hydrolytic enzyme preparations, namely Pectinex® Ultra ...
Zafeiria Lemoni, Styliani Kalantzi, Theopisti Lymperopoulou, Andromachi Tzani, Georgios Stavropoulos, Anastasia Detsi, Diomi Mamma   +6 more
wiley   +1 more source

Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP‑1 Monocytes

, 2018
Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence of the conversion of phenols to corresponding catechol derivatives, as evaluated by DPPH, Comet assay, and
Roberta Meschini, Laura Bertini (3266379), Francesca Velotti, Lorenzo Botta (1478104), Roberta Meschini (4090627), Bruno Mattia Bizzarri (2553112), Donatella D’Eliseo, Raffaele Saladino (34329), Francesca Velotti (5941676), Donatella D’Eliseo (5941673), Silvia Filippi (747669), Silvia Filippi, Lorenzo Botta, Laura Bertini, Raffaele Saladino, Bruno Mattia Bizzarri   +15 more
core   +1 more source

Inactivation of Tyrosinase by Dopa

Journal of Investigative Dermatology, 1980
Tyrosinase in a melanosome is known to be inactivated during melanin formation in vivo, and a similar inactivation was observed in vitro when melanosomes isolated from Harding Passey mouse melanoma were incubated with dopa. Tyrosinase, whether particle bound or in soluble form, was inactivated during the dopa-tyrosinase reaction and the reduction rate ...
Tomita, Yasushi, Hariu, Akiko, Mizuno, Chikako, Seiji, Makoto   +3 more
openaire   +2 more sources

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules
Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis.
Xinhua Ni, Xinyu Luo, Xiaoying Jiang, Wenchao Chen, Renren Bai   +4 more
doaj   +1 more source