Results 81 to 90 of about 54,266 (256)

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Membranes
Lysosomal degradation of tyrosinase, a pivotal enzyme in melanin synthesis, negatively impacts melanogenesis in melanocytes. Nevertheless, the precise molecular mechanisms by which lysosomes target tyrosinase have remained elusive. Here, we identify RING
Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C. J. M. D. S. Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita   +9 more
doaj   +1 more source

Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin‐specific quality specification

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Geographic origin influences the phytochemical composition and biological activities of medicinal plant resources. Xanthium strumarium L. (XS) fruit is widely used in East Asian traditional medicine. However, current pharmacopeial standards primarily recognize Chinese‐derived material, despite the availability and traditional use of
Eunsu Song, Seung‐Min Oh, Jiyeon Chun, Jinah Hwang   +3 more
wiley   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules
Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis.
Xinhua Ni, Xinyu Luo, Xiaoying Jiang, Wenchao Chen, Renren Bai   +4 more
doaj   +1 more source

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Angewandte Chemie, 2017
Tyrosinase‐related protein 1 (TYRP1) is one of three tyrosinase‐like glycoenzymes in human melanocytes that are key to the production of melanin, the compound responsible for the pigmentation of skin, eye, and hair.
X. Lai, H. Wichers, M. Soler‐Lopez, B. Dijkstra   +3 more
semanticscholar   +1 more source

Inactivation of Tyrosinase by Dopa

Journal of Investigative Dermatology, 1980
Tyrosinase in a melanosome is known to be inactivated during melanin formation in vivo, and a similar inactivation was observed in vitro when melanosomes isolated from Harding Passey mouse melanoma were incubated with dopa. Tyrosinase, whether particle bound or in soluble form, was inactivated during the dopa-tyrosinase reaction and the reduction rate ...
Tomita, Yasushi, Hariu, Akiko, Mizuno, Chikako, Seiji, Makoto   +3 more
openaire   +2 more sources

Vitiligo and Skin Cancer Risk: A Systematic Review and Meta‐Analysis With Subtype and Phototherapy Stratification

JEADV Clinical Practice, EarlyView.
Vitiligo was associated with directionally lower odds of melanoma and non‐melanoma skin cancer in this systematic review and meta‐analysis of 14 studies. A statistically significant inverse association was observed for squamous cell carcinoma. Phototherapy exposure showed higher, but non‐significant, point estimates for melanoma and non‐melanoma skin ...
Simonetta I. Gaumond, Luis F. Andrade, Peyton V. Warp, Isabella Kamholtz, Sophie Shrestha, Hannah Metheny, Alireza Abdshah, Paolo Romanelli, Joaquin J. Jimenez   +8 more
wiley   +1 more source

Membrane-Associated Transporter Protein (MATP) Regulates Melanosomal pH and Influences Tyrosinase Activity.

PLoS ONE, 2015
The SLC45A2 gene encodes a Membrane-Associated Transporter Protein (MATP). Mutations of this gene cause oculocutaneous albinism type 4 (OCA4). However, the molecular mechanism of its action in melanogenesis has not been elucidated.
Bum-Ho Bin, Jinhyuk Bhin, Seung Ha Yang, Misun Shin, Yeon-Ju Nam, Dong-Hwa Choi, Dong Wook Shin, Ai-Young Lee, Daehee Hwang, Eun-Gyung Cho, Tae Ryong Lee   +10 more
doaj   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source