Results 81 to 90 of about 39,961 (248)

Rosa × damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition

Frontiers in Pharmacology
Tyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving increasing attention. Rosa × damascena Herrm. essential oil (RDEO), as important functional metabolites, was widely known due to its biological activities.
Qiuyan Wu, Wanting Fang, Hao Liu, Zhong Liu, Xuetao Xu   +4 more
doaj   +1 more source

Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne‐Related Post‐Inflammatory Hyperpigmentation: A Cross‐Sectional Study Highlighting the Need for Targeted Education

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real‐world sunscreen practices in this group. This study aimed to evaluate sunscreen use, barriers and factors influencing adherence
Xiaozhun Hang, Davin Sui Lim, Lisa Byrom
wiley   +1 more source

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives

Drug Design, Development and Therapy, 2017
Do Hyun Kim,1 Su Jeong Kim,1 Sultan Ullah,1 Hwi Young Yun,1 Pusoon Chun,2 Hyung Ryong Moon1 1College of Pharmacy, Pusan National University, Busan, 2College of Pharmacy, Inje University, Gimhae, South Korea Abstract: The authors designed and ...
Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR   +5 more
doaj  

Novel tyrosinase inhibitory peptide with free radical scavenging ability

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a key enzyme involved in melanin synthesis. Therefore, various tyrosinase inhibitors have been screened by researchers in recent years. In the present study, we discovered a novel tyrosinase inhibitor, a peptide ECGYF (named EF-5), with ...
Zhiwei Shen, Yujiao Wang, Zhen Guo, Tingyuan Tan, Yi Zhang   +4 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Recent advances of emergent extraction technologies to enhance bioactive compounds extraction of microalgae—An overview towards application in cosmetics

International Journal of Cosmetic Science, EarlyView.
Microalgae extracts show immense potential in cosmetics for their bioactivities; emerging extraction techniques enhance bioactive compound yield from microalgae. Abstract Microalgae have attracted significant interest in numerous sectors, particularly in the cosmetic industries, owing to their rich composition of bioactive compounds. This paper aims to
Alireza Mousakhani Ganjeh, Lucília da P. da Silva, Carlos A. Pinto, Rosário Martins, Alexandra P. Marques, Jorge A. Saraiva   +5 more
wiley   +1 more source

Tyrosinase-Catalyzed Oxidation of the Leukoderma-Inducing Agent Raspberry Ketone Produces (E)‑4-(3-Oxo-1-butenyl)-1,2-benzoquinone: Implications for Melanocyte Toxicity

, 2017
The exposure of human skin to 4-(4-hydroxyphenyl)-2-butanone (raspberry ketone, RK) is known to cause chemical/occupational leukoderma. RK has a structure closely related to 4-(4-hydroxyphenyl)-2-butanol (rhododendrol), a skin whitening agent that was ...
Shosuke Ito (55670), Maki Hinoshita (3814780), Erina Suzuki (431474), Makoto Ojika (504409), Kazumasa Wakamatsu (55669)   +4 more
core   +1 more source

Degradation of Tyrosinase by Melanosomal pH Change and a New Mechanism of Whitening with Propylparaben

Cosmetics, 2017
Many active cosmetic ingredients formulated as medicated whitening products (quasi-drugs) achieve their effect through inhibition of tyrosinase activity, but no products can achieve this effect through degradation of intramelanosomal tyrosinase.
Haifeng Zeng, Akane Harashima, Koichi Kato, Lihao Gu, Yosuke Motomura, Ryoichi Otsuka, Kazuhisa Maeda   +6 more
doaj   +1 more source

A Competitive Inhibitor of Tyrosinase [PDF]

Australian Journal of Biological Sciences, 1951
The kinetics of the activation of catechol by tyrosinase prepared from the potato and the mushroom, and of its inhibition by sodium m-hydroxybenzoate, have been studied. The enzyme-substrate dissociation constants differed markedly between the two enzyme sources (K.
openaire   +2 more sources

Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin

International Journal of Cosmetic Science, EarlyView.
Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang, Hong Zhang, Chengming Zhang, Wencai Jiang, Luonan Chen, Yimei Tan, Ying Zou, Xuelan Gu   +7 more
wiley   +1 more source