Results 91 to 100 of about 54,266 (256)

Rosa × damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition

Frontiers in Pharmacology
Tyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving increasing attention. Rosa × damascena Herrm. essential oil (RDEO), as important functional metabolites, was widely known due to its biological activities.
Qiuyan Wu, Wanting Fang, Hao Liu, Zhong Liu, Xuetao Xu   +4 more
doaj   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases

Molecules
Based on the fact that substances with a β-phenyl-α,β-unsaturated carbonyl (PUSC) motif confer strong tyrosinase inhibitory activity, benzylidene-3-methyl-2-thioxothiazolidin-4-one (BMTTZD) analogs 1–8 were prepared as potential tyrosinase inhibitors ...
Hye Jin Kim, Hee Jin Jung, Young Eun Kim, Daeun Jeong, Hyeon Seo Park, Hye Soo Park, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon   +10 more
doaj   +1 more source

Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest

Industrial crops and products (Print), 2018
In search for natural products of cosmetic interest, a hundred plant extracts were in vitro tested against elastase and tyrosinase. The inhibitors of these enzymes find application as skin whitening, anti-ageing, anti-wrinkle agents as well as in the ...
I. Chiocchio, M. Mandrone, C. Sanna, A. Maxia, M. Tacchini, F. Poli   +5 more
semanticscholar   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo

Molecules, 2017
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins.
C. Niu, H. Aisa
semanticscholar   +1 more source

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives

Drug Design, Development and Therapy, 2017
Do Hyun Kim,1 Su Jeong Kim,1 Sultan Ullah,1 Hwi Young Yun,1 Pusoon Chun,2 Hyung Ryong Moon1 1College of Pharmacy, Pusan National University, Busan, 2College of Pharmacy, Inje University, Gimhae, South Korea Abstract: The authors designed and ...
Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR   +5 more
doaj  

Tyrosinase inhibitors as potential antibacterial agents.

European journal of medicinal chemistry, 2019
Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses ...
Ye Yuan, Wanli Jin, Yasir Nazir, Christian Fercher, M. Blaskovich, M. Cooper, R. Barnard, Z. Ziora   +7 more
semanticscholar   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Novel tyrosinase inhibitory peptide with free radical scavenging ability

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a key enzyme involved in melanin synthesis. Therefore, various tyrosinase inhibitors have been screened by researchers in recent years. In the present study, we discovered a novel tyrosinase inhibitor, a peptide ECGYF (named EF-5), with ...
Zhiwei Shen, Yujiao Wang, Zhen Guo, Tingyuan Tan, Yi Zhang   +4 more
doaj   +1 more source