Results 21 to 30 of about 54,266 (256)
Molecules, 2023 Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis. In the current review, different chemical derivatives are explored which have been used as anti-melanogenic compounds.
Mubashir Hassan +2 more
semanticscholar +1 more source
Naturally-Occurring Tyrosinase Inhibitors Classified by Enzyme Kinetics and Copper Chelation
International Journal of Molecular Sciences, 2023 Currently, there are three major assaying methods used to validate in vitro whitening activity from natural products: methods using mushroom tyrosinase, human tyrosinase, and dopachrome tautomerase (or tyrosinase-related protein-2, TRP-2).
Hee-Do Kim +6 more
semanticscholar +1 more source
Molecules, 2023 Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with ...
Li Lu +5 more
doaj +1 more source
Comparative Study of High-throughput Screening Models for Anti-hyperpigmentation Compounds
Brazilian Archives of Biology and Technology, 2022 The mushroom tyrosinase assay, B16-F10 mouse melanoma cell model, and zebrafish model are frequently used for high-throughput screening and are widely used for developing anti-hyperpigmentation compounds, although these systems cannot be compared.
Tingwei Sun +7 more
doaj +1 more source
Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration.
The Journal of pharmacy and pharmacology, 2023 OBJECTIVES The co-occurrence of melanoma and Parkinson's disease (PD) is higher than expected. We review the relationship between melanoma and PD, then proffer a hypothesis of how dysregulated human tyrosinase could be involved in both diseases via the ...
Wanli Jin +4 more
semanticscholar +1 more source
Computational and Structural Biotechnology Journal, 2022 As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-b]thiazol-3(2H)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template.
Heejeong Choi +11 more
doaj +1 more source
Recent advances in triazoles as tyrosinase inhibitors.
European journal of medicinal chemistry, 2023 The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a significant position in melanogenesis, plays an important role in undesirable browning of fruits and vegetables, antibiotic resistance, skin pigment formation ...
Arif Mermer, S. Demirci
semanticscholar +1 more source
RSC Advances, 2021 Tyrosinase is a multifunctional glycosylated and copper-containing oxidase that is highly prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of melanogenesis: tyrosine's hydroxylation to dihydroxyphenylalanine (DOPA),
R. Obaid +7 more
semanticscholar +1 more source
In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template
Computational and Structural Biotechnology Journal, 2021 The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized.
Inkyu Choi +11 more
doaj +1 more source
Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity: A Survey from 2016 to 2021
Molecules, 2021 Tyrosinase is a multifunctional copper-containing oxidase enzyme that initiates melanin synthesis in humans. Excessive accumulation of melanin pigments or the overexpression of tyrosinase may result in skin-related disorders such as aging spots, wrinkles,
H. El-Nashar +3 more
semanticscholar +1 more source