Results 11 to 20 of about 53,271 (260)
Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as ...
Thanigaimalai Pillaiyar +2 more
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Molecules, 2022 Skin hyperpigmentation resulting from excessive tyrosinase expression has long been a problem for beauty lovers, which has not yet been completely solved.
Yuqiong Song +4 more
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Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins [PDF]
Chemistry – A European Journal, 2017 AbstractMelanin is the main pigment responsible for the color of human skin, hair and eye. Its biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase‐related proteins TYRP1 and TYRP2. The difficulty of isolating pure and homogeneous proteins from endogenous sources has hampered their study, and resulted in many ...
Xuelei Lai +3 more
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Tyrosinase Inhibitors: A Perspective
Molecules, 2023 Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have made it to the market in the cosmetics industry, but their use has been limited due to conflicting ...
Mason A. Baber +3 more
openaire +4 more sources
Inhibition of Tyrosinase by Mercury Chloride: Spectroscopic and Docking Studies
Frontiers in Pharmacology, 2020 Inorganic mercury compounds have been used in skin-lightening products since ancient times. Although a previous study demonstrated that mercury impeded the transfer of Cu2+ to the apotyrosinase, the effect of mercury on tyrosinase is still unclear.
Jianmin Chen +8 more
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Naturally-Occurring Tyrosinase Inhibitors Classified by Enzyme Kinetics and Copper Chelation
International Journal of Molecular Sciences, 2023 Currently, there are three major assaying methods used to validate in vitro whitening activity from natural products: methods using mushroom tyrosinase, human tyrosinase, and dopachrome tautomerase (or tyrosinase-related protein-2, TRP-2).
Hee-Do Kim +6 more
semanticscholar +1 more source
RSC Advances, 2021 Tyrosinase is a multifunctional glycosylated and copper-containing oxidase that is highly prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of melanogenesis: tyrosine's hydroxylation to dihydroxyphenylalanine (DOPA),
R. Obaid +7 more
semanticscholar +1 more source
Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity: A Survey from 2016 to 2021
Molecules, 2021 Tyrosinase is a multifunctional copper-containing oxidase enzyme that initiates melanin synthesis in humans. Excessive accumulation of melanin pigments or the overexpression of tyrosinase may result in skin-related disorders such as aging spots, wrinkles,
H. El-Nashar +3 more
semanticscholar +1 more source
Nature Communications, 2019 In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD.
Iria Carballo-Carbajal +15 more
semanticscholar +1 more source
Phlorotannins Derived From the Brown Alga as Tyrosinase Inhibitors
Natural Product Communications, 2021 Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase
Hideyuki Kurihara, Kazuki Kujira
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