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Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins [PDF]
Chemistry - A European Journal, 2018 AbstractMelanin is the main pigment responsible for the color of human skin, hair and eye. Its biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase‐related proteins TYRP1 and TYRP2. The difficulty of isolating pure and homogeneous proteins from endogenous sources has hampered their study, and resulted in many ...
Bauke Dijkstra +2 more
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Tyrosinase Inhibitors: A Perspective
Molecules, 2023 Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have
James Patrone
exaly +5 more sources
Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as ...
Thanigaimalai Pillaiyar +2 more
doaj +2 more sources
A comprehensive review on tyrosinase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning.
FRANCISCO García-Cánovas +2 more
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Molecules, 2022 Skin hyperpigmentation resulting from excessive tyrosinase expression has long been a problem for beauty lovers, which has not yet been completely solved.
Yuqiong Song +4 more
doaj +2 more sources
An Updated Review of Tyrosinase Inhibitors
International Journal of Molecular Sciences, 2009 Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing.
Te-Sheng Chang, Chang Te-Sheng
exaly +2 more sources
Journal of Investigative Dermatology, 2018 Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target for inhibiting hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were ...
Ludger Kolbe +2 more
exaly +2 more sources
Inhibition of Tyrosinase by Mercury Chloride: Spectroscopic and Docking Studies
Frontiers in Pharmacology, 2020 Inorganic mercury compounds have been used in skin-lightening products since ancient times. Although a previous study demonstrated that mercury impeded the transfer of Cu2+ to the apotyrosinase, the effect of mercury on tyrosinase is still unclear.
Jianmin Chen +8 more
doaj +2 more sources
Recent advances in the design and discovery of synthetic tyrosinase inhibitors
European Journal of Medicinal Chemistry, 2021 Liang Ouyang, Xiuying Hu, Guan Wang
exaly +2 more sources
Molecules, 2021 Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai +4 more
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