Results 11 to 20 of about 39,961 (248)

Melanization and Tyrosinase Activity

Journal of Investigative Dermatology, 1971
Purified soluble tyrosinase isolated from the melanosomes of Harding-Passey mouse melanoma was incubated with L-dopa. The reaction velocity of the tyrosinase thus incubated decreased significantly. There was an inverse linear relationship between the concentration of dopa in the preincubation mixture and the reaction velocity of the tyrosinase which ...
Seiji, Makoto, Miyazaki, Kazuhiro
openaire   +3 more sources

Tyrosinase-Mediated Synthesis of Nanobody–Cell Conjugates

, 2022
A convenient enzymatic strategy is reported for the modification of cell surfaces. Using a tyrosinase enzyme isolated from Agaricus bisporus, unique tyrosine residues introduced at the C-termini of nanobodies can be site-selectively oxidized to reactive ...
Daniel K. Nomura (198023), Johnathan C. Maza (1416832), Noah X. Hamlish (12906839), Derek M. García-Almedina (11942742), Lydia E. Boike (12906836), Matthew B. Francis (425831)   +5 more
core   +3 more sources

Tyrosinase-Based Proximity Labeling in Living Cells and In Vivo

Characterizing the protein constituents of a specific organelle and protein neighbors of a protein of interest (POI) is essential for understanding the function and state of the organelle and protein networks associated with the POI.
Hao Zhu (56502), Takeharu Mino (18113318), Jae Hoon Oh (5353406), Hiroshi Nonaka (2059858), Mamoru Ishikawa (18113321), Itaru Hamachi (846758), Yuna Matsuda (18113315), Hideki Nakamura (1543762), Muneo Tsujikawa (4892344)   +8 more
core   +8 more sources

Experimental Evidence and Mechanistic Description of the Phenolic H‑Transfer to the Cu₂O₂ Active Site of oxy-Tyrosinase

, 2023
Tyrosinase is a ubiquitous coupled binuclear copper enzyme that activates O2 toward the regioselective monooxygenation of monophenols to catechols via a mechanism that remains only partially defined.
Martin Srnec (1263150), Agnieszka Stańczak (17175044), Jake W. Ginsbach (1645351), Ioannis Kipouros (17175041), Lubomír Rulíšek (1263147), Eleanor M. Dunietz (17175047), Edward I. Solomon (177653)   +6 more
core   +2 more sources

Tyrosinase-Catalyzed Peptide Macrocyclization for mRNA Display

, 2023
mRNA display of macrocyclic peptides has proven itself to be a powerful technique to discover high-affinity ligands for a protein target. However, only a limited number of cyclization chemistries are known to be compatible with mRNA display.
Albert A. Bowers, Rodney Park, Albert A. Bowers (1635184), Matthew C. Fleming (12511044), Rodney Park (12034850), Matthew M. Bowler (11973582), Konstantin I. Popov (6519812), Matthew M. Bowler, Konstantin I. Popov, Matthew C. Fleming   +9 more
core   +1 more source

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone [PDF]

, 2011
Tyrosinase catalyzes the conversion of phenolic compounds into their quinone derivatives, which are precursors for the formation of melanin, a ubiquitous pigment in living organisms.
Dijkstra, B.W., Dijkstra, Bauke W., Weijn, A., Bauke W. Dijkstra, Amrah Weijn, Wangsa T. Ismaya, Ismaya, Wangsa T.,, Rozeboom, Henriette J.; id_orcid, Dijkstra, Bauke W.,, Rozeboom, H.J., Jurriaan J. Mes, Harry J. Wichers, Ismaya, Wangsa T., Weijn, Amrah,, Mes, J.J., Ismaya, W.T., Fusetti, F., Wichers, Harry J.,, Fabrizia Fusetti, Mes, Jurriaan J., Fusetti, Fabrizia,, Wichers, Harry J., Fusetti, Fabrizia, Mes, Jurriaan J.,, Wichers, H.J., Rozeboom, Henriette J., Henriëtte J. Rozeboom, Rozeboom, Henriëtte J.,, Weijn, Amrah   +28 more
core   +1 more source

Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins [PDF]

Chemistry – A European Journal, 2017
AbstractMelanin is the main pigment responsible for the color of human skin, hair and eye. Its biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase‐related proteins TYRP1 and TYRP2. The difficulty of isolating pure and homogeneous proteins from endogenous sources has hampered their study, and resulted in many ...
Xuelei Lai, Harry J. Wichers, Montserrat Soler‐Lopez, Bauke W. Dijkstra   +3 more
openaire   +3 more sources

In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives

Computational and Structural Biotechnology Journal, 2019
Tyrosinase is a key enzyme responsible for melanin biosynthesis and is effective in protecting skin damage caused by ultraviolet radiation. As part of ongoing efforts to discover potent tyrosinase inhibitors, we systematically designed and synthesized ...
Hee Jin Jung, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon   +6 more
doaj   +1 more source

Phlorotannins Derived From the Brown Alga as Tyrosinase Inhibitors

Natural Product Communications, 2021
Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase
Hideyuki Kurihara, Kazuki Kujira
doaj   +1 more source

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

Molecules, 2018
In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities.
Chang Seok Kim, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hee Jin Jung, Hyung Ryong Moon   +7 more
doaj   +1 more source