Results 11 to 20 of about 45,442 (272)

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules
Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis.
Xinhua Ni, Xinyu Luo, Xiaoying Jiang, Wenchao Chen, Renren Bai   +4 more
doaj   +2 more sources

Tyrosinase-Mediated Synthesis of Nanobody–Cell Conjugates

, 2022
A convenient enzymatic strategy is reported for the modification of cell surfaces. Using a tyrosinase enzyme isolated from Agaricus bisporus, unique tyrosine residues introduced at the C-termini of nanobodies can be site-selectively oxidized to reactive ...
Daniel K. Nomura (198023), Johnathan C. Maza (1416832), Noah X. Hamlish (12906839), Derek M. García-Almedina (11942742), Lydia E. Boike (12906836), Matthew B. Francis (425831)   +5 more
core   +3 more sources

Experimental Evidence and Mechanistic Description of the Phenolic H‑Transfer to the Cu₂O₂ Active Site of oxy-Tyrosinase

, 2023
Tyrosinase is a ubiquitous coupled binuclear copper enzyme that activates O2 toward the regioselective monooxygenation of monophenols to catechols via a mechanism that remains only partially defined.
Martin Srnec (1263150), Agnieszka Stańczak (17175044), Jake W. Ginsbach (1645351), Ioannis Kipouros (17175041), Lubomír Rulíšek (1263147), Eleanor M. Dunietz (17175047), Edward I. Solomon (177653)   +6 more
core   +2 more sources

An investigation into the role of autoimmunity in vitiligo [PDF]

, 2002
Vitiligo is an acquired depigmenting disorder characterised by the loss of functional melanocytes from the cutaneous epidermis. A role for autoimmunity is supported by the presence of circulating antibodies and T lymphocytes which react against ...
Waterman, Elizabeth Ann
core   +5 more sources

Tyrosinase-Catalyzed Peptide Macrocyclization for mRNA Display

, 2023
mRNA display of macrocyclic peptides has proven itself to be a powerful technique to discover high-affinity ligands for a protein target. However, only a limited number of cyclization chemistries are known to be compatible with mRNA display.
Albert A. Bowers, Rodney Park, Albert A. Bowers (1635184), Matthew C. Fleming (12511044), Rodney Park (12034850), Matthew M. Bowler (11973582), Konstantin I. Popov (6519812), Matthew M. Bowler, Konstantin I. Popov, Matthew C. Fleming   +9 more
core   +1 more source

Determination of tyrosinase-cyanidin-3-O-glucoside and (−/+)-catechin binding modes reveal mechanistic differences in tyrosinase inhibition

Scientific Reports, 2021
Tyrosinase, exquisitely catalyzes the phenolic compounds into brown or black pigment, inhibition is used as a treatment for dermatological or neurodegenerative disorders. Natural products, such as cyanidin-3-O-glucoside and (−/+)-catechin, are considered
Kyung Eun Lee, Shiv Bharadwaj, Amaresh Kumar Sahoo, Umesh Yadava, Sang Gu Kang   +4 more
doaj   +1 more source

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Christopher Cheng, Elena Sviderskaya, Sviderskaya, EV, Lam, RY, Zhi-Xiu Lin, Lin, ZX, Rosanna Lam, Cheng, CH   +7 more
core   +1 more source

In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives

Computational and Structural Biotechnology Journal, 2019
Tyrosinase is a key enzyme responsible for melanin biosynthesis and is effective in protecting skin damage caused by ultraviolet radiation. As part of ongoing efforts to discover potent tyrosinase inhibitors, we systematically designed and synthesized ...
Hee Jin Jung, Sang Gyun Noh, Yujin Park, Dongwan Kang, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon   +6 more
doaj   +1 more source

Exploring the Cosmeceutical Potential of Six Malaysian Indigenous Tropical Fruit Trees: Radical Scavenging, Anti-Tyrosinase, and Photoprotective Activities Evaluation. [PDF]

Chem Biodivers
B. macrophylla leaf ethyl acetate fractionated extract exhibits the highest TPC, very strong radical‐scavenging activities, and the highest SPF value of 28.64 ± 0.51. LC‐MS analysis identifies m‐trigallic acid, cis‐coutaric acid, and ellagic acid, which may contribute to its bioactivities. The present work highlights B.
Chong WL, Teoh ZN, Ramli NA, Manickam S, Lim SH, Tan CH, Sim KS, Saad HM.   +7 more
europepmc   +2 more sources

Characterization of Tyrosinase Inhibitors in Dryopteris crassirhizoma Rhizome Using a Combination of High-Speed Counter-Current Chromatography, Affinity-Based Ultrafiltration, and Liquid Chromatography–Tandem Mass Spectrometry

Frontiers in Nutrition, 2022
Dryopteris crassirhizoma rhizome (DCR) inhibits melanin production in B16F10 melanoma cells and tyrosinase activity. The melanin content and tyrosinase activity of DCR-treated zebrafish embryos were determined to evaluate the in vivo inhibitory effect of
Zhiqiang Wang, Ning Wang, Dandan Han, Hongyuan Yan, Hongyuan Yan   +4 more
doaj   +1 more source