Results 111 to 120 of about 256,731 (319)

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators

Molecules, 2017
A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, 1H-NMR and mass spectroscopy.
Samar Said Fatahala, Sherifa Hasabelnaby, Ayman Goudah, Ghada I. Mahmoud, Rania Helmy Abd-El Hameed   +4 more
doaj   +1 more source

Parallel Electrical Integration of Photo Bio Electrochemical Systems (photo‐BESs): Performance Gains and Load Dependency

Advanced Materials Technologies, EarlyView.
Parallel wiring of bioelectrochemical devices with conventional generators unexpectedly boosts output. A biophotovoltaic paired with a solar cell delivers up to 50% more power at low loads than their separate contributions; a plant microbial fuel cell shows similar current gains.
Valeria Marsaglia, Paolo Bombelli, Ingrid Paoletti, Ioannis A. Ieropoulos, Christopher J. Howe   +4 more
wiley   +1 more source

A Molecular Docking and Dynamic Simulation Study for the Inhibition of Porcine Corona Virus: Drug Repurposing Approach

, 2023
Severe acute respiratory syndrome (SARS) coronavirus-2 was declared as world pandemic by WHO in 2019. It has been spreading very rapidly around the world and responsible for various health issues.
Shweta, Mishra, Suman, Mukhopadhyay, Anupama, Tiwari, G. N., Darwhekar   +3 more
core   +1 more source

Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase

To Chemistry Journal, 2020
In our attempt to exploring a new class of antimicrobial and antioxidant agents, novel 4,5-dihydro-1H-pyrazole derivatives were synthesized and characterized by some spectroscopic methods such as FTIR, 1HNMR, and GCMS.
Ahmed Mutanabbi Abdula, Ban Hasan Taresh, Mustafa Taha Mohammed, Salah M Baqer, Mohammed A. AL-Jaleel Khalil, Ali Hameed Rasheed   +5 more
doaj  

Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin

Molecules, 2017
It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin. In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity ...
Masaki Ikeda, Manabu Ueda-Wakagi, Kaori Hayashibara, Rei Kitano, Masaya Kawase, Kunihiro Kaihatsu, Nobuo Kato, Yoshitomo Suhara, Naomi Osakabe, Hitoshi Ashida   +9 more
doaj   +1 more source

Multimodal Human–Robot Interaction Using Human Pose Estimation and Local Large Language Models

Advanced Robotics Research, EarlyView.
A multimodal human–robot interaction framework integrates human pose estimation (HPE) and a large language model (LLM) for gesture‐ and voice‐based robot control. Speech‐to‐text (STT) enables voice command interpretation, while a safety‐aware arbitration mechanism prioritizes gesture input for rapid intervention.
Nasiru Aboki, Ilche Georgievski, Marco Aiello   +2 more
wiley   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Simulation and Optimization of Space Docking Mechanism

, 2002
Dynamic simulation is essential to the study on the space docking mechanism, docking dynamics and the development of new design concepts for advanced docking system.
Qu YL(曲艳丽), Zhao MY(赵明扬), Xiao, Yuzhi, Zhang CF(张崇峰)   +3 more
core  

SCREENING INTERACTIONS BETWEEN PROTEINS AND DISORDERED PEPTIDES BY A NOVEL COMPUTATIONAL METHOD [PDF]

, 2013
Concerted interactions between proteins in cells form the basis of most biological processes. Biophysicists study protein–protein association by measuring thermodynamic and kinetic properties.
Zhang, Weiyi
core  

Synthesis and Biological Evaluation of Novel <em>N</em>-Methyl-picolinamide-4-thiol Derivatives as Potential Antitumor Agents

Molecules, 2012
A novel series of <em>N</em>-methylpicolinamide-4-thiol derivatives were synthesized and evaluated on human cancer cell lines. Among them, compound <strong>6p</strong> displayed potent and<strong> </strong>broad ...
Luo-Ting Yu, Ting-Hong Ye, Xun Luo, Yong Xia, Ting-Ting Huang, Yun-Chuang Huang, Xiao-Yu Qing   +6 more
doaj   +1 more source