Results 101 to 110 of about 1,096,581 (266)

Doctor Watson Architects: Corviale, Collection

, 2017
It was our investigation of the 1 kilometre long housing block called Corviale (on the periphery of Rome) that led to the invention of the 'beetles' and so we tend to classify all of our beetle-based inquiries under the Corviale name, even where they ...
Watson, V.A.
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Analisis Strategi Komunikasi dalam Upaya Membangun Keharmonisan Keluarga pada Pasangan Dokter di Palemban

Rayah Al-Islam
Marriage represents an important stage in a person's life. The purpose is not only at forming a family but also at creating a harmonious family. One of the key in building such harmony is an effective communication between spouses. Poor communication can
Thalia Rosa Carella, Yusdi Haq
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Restaurant Doctor

Most people probably don't want to hear the words "restaurant" and "doctor" in the same sentence, but for those seeking assistance with managing their own restaurant, hearing those two words together may be just the tonic they ...
Marvin, Bill
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Homenaje al doctor Román Piña Chan [PDF]

En este merecido homenaje que la Universidad Nacional Autónoma de México rinde hoy al doctor Román Piña Chan, deseo destacar aspectos importantes y centrales de su obra, que están muy ligados con el Instituto Nacional de Antropología e ...
Florescano, Doctor Enrique
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Knowledge, attitude, and practice of artificial intelligence among doctors and medical students in Saudi Arabia

Journal of Family Medicine and Primary Care
Background: Artificial intelligence (AI) is advancing rapidly across fields, including healthcare, where it is being adopted for diagnostics and patient management.
Faisal A. Alabbad, Aljohara S. Almeneessier, Mohammed Hisham Alshalan, Mohammad N. Aljarba   +3 more
doaj   +1 more source