Results 81 to 90 of about 905,868 (291)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Doctor Watson Architects: Bots, Collection
, 2018 There is a long tradition in the history of architecture of hybridising sculpture and building, we are currently investigating the possibilities of expanding the same line of enquiry into the realm of artificial intelligence and robotics. We are not only
Watson, V.A.
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Global Health ActionBackground Nigeria faces a critical shortage of healthcare professionals yet experiences a significant annual exodus of doctors and dentists. This alarming trend threatens the country’s ability to provide equitable healthcare.
Oghenebrume Wariri +18 more
doaj +1 more source
International Journal of Women's Health, 2023 Derya Suluhan,1 Esra Keles,2 Rahma Yusuf Haji Mohamud,3 Hasan Hüseyin Eker,4 Sertac Cimen,5 Neşe Yakşi,6 Dilek Yildiz7 1Department of Nursing, Somalia Mogadishu Recep Tayyip Erdoğan Faculty of Health Sciences, Mogadishu, Somalia ...
Suluhan D +6 more
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THE INFLUENCE OF ARTIFICIAL INTELLIGENCE ON THE FORMATION OF FUTURE DOCTORS WHEN STUDYING BIOPHYSICS AT A MEDICAL UNIVERSITY [PDF]
Vestnik Issyk-Kulʹskogo universitetaThis article examines the impact of artificial intelligence on the formation of future doctors while studying biophysics at a medical university. The role of medical professionals is changing as this article examines the multidimensional impact of AI on ...
Urazakynov D. K.
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Journal of Multidisciplinary Healthcare, 2021 Song Wang,1,* Rui-Chen Gao,2,* Rui Li,3,* Guo-Cui Wu1 1Lianhua Community Health Service Center, The Second Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2School of Nursing, Anhui Medical University, Hefei,
Wang S, Gao RC, Li R, Wu GC
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Distributed online doctor surgery [PDF]
, 2002 This paper reports on redesign of the existing manual system of a Doctor Surgery, to a computerised system, which takes the advantage of the latest technologies and allows the patients to have better interaction with the system. The Doctor surgery plays
Jahankhani, P., Jahankhani, H.
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