Results 81 to 90 of about 1,096,581 (266)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
'Conditions of time and space': a re-enactment experiment with the British TV series Doctor Who. [PDF]
The aim of this thesis is to provide a contribution to knowledge in two areas. Firstly, it seeks to further our understanding of the historical conditions of British television drama production; in particular the constraining and liberating influences of
Ireland, Andrew
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Introduction to Doctor Who and science
, 2021 This chapter reviews representations of science and scientists in Doctor Who from 1963 to 2020, and critically reviews scholarship and popular works about science and Doctor Who from the past 40 ...
Orthia, Lindy, Harmes, Marcus K.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Medical and sanitary service of northern part of Bukovyna after the First World War (1918-1928)
Науковий вісник Чернівецького національного університету імені Юрія Федьковича. Історія, 2023 The article deals with the main trends in the restoration and development of the medical and sanitary service in the territory of Northern Bukovyna in 1918-1928, during which martial law continued here, after which the territory became part of the ...
Оксана Гучко +1 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Solicitud de Candidato a Doctor
, 2021 Explicación del procedimiento solicitud de estado "Candidato a doctor". 1. definición. 2. propósitos 3. requisitos. 4. certificación nivel de inglés. 5.
Espitia Morales, María José
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
The duality of the nature of dialogue in philosophy and medical practice
Studia Humanitatis, 2019 The article analyses the duality of nature in relationships between the doctor and the patient. This research was conducted in the context of M. Buber’s philosophy.
Koroleva Elena Pavlovna +1 more
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