Results 101 to 110 of about 273,044 (344)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

University of Idaho President Donald Theophilus receives an honorary Doctor of Science degree at Commencement

open access: yes, 1961
University of Idaho President Donald Theophilus receives an honorary Doctor of Science degree from John J. Peacock (right), president of the Board of Regents during the 1961 Commencement ceremony.

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A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

J.R. Simplot receives an honorary Doctor of Administrative Science degree

open access: yes, 1975
J.R. Simplot, chairman of the board and founder of J.R. Simplot Co., receives an honorary Doctor of Administrative Science degree during the 1975 Commencement ...

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Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Restaurant Doctor

open access: yes
Most people probably don't want to hear the words "restaurant" and "doctor" in the same sentence, but for those seeking assistance with managing their own restaurant, hearing those two words together may be just the tonic they ...
Marvin, Bill
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Honorary Doctor of Science presented to Neil Armstrong from the University of Cincinnati, June 6, 1982

open access: yes, 2013
Rolled Document: Honorary Doctor of Science from the University of Cincinnati, June 13 ...
Barrett, Charles M., 1913-1989   +1 more
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Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Clayton Loosli receiving an honorary Doctor of Science degree [4]

open access: yes, 1958
Clayton Loosli receiving an honorary Doctor of Science degree from University of Idaho President Donald Theophilus during the 1958 Commencement ceremony. Dr. Boyd A.

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